Bacterial Resistance in Biofilm-Associated Bacteria

Venkatesan, Nandakumar; Perumal, Govindaraj; Doble, Mukesh

doi:10.2217/fmb.15.69

Cited by 173 publications

(117 citation statements)

References 25 publications

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“…It is well known that biofilm provides a protective environment for microorganisms due to a decreased penetration of antimicrobial agents, the low metabolic activity, and the ability to concentrate enzymes that can inactivate antibiotics (Venkatesan, Perumal, & Doble, ). This contributes to the persistence of microbial infections and treatment failures.…”

Section: Discussionmentioning

confidence: 99%

Tart cherry (Prunus cerasus L.) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function

Lagha

LeBel

Grenier

2019

Phytotherapy Research

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Dental caries, candidiasis, and periodontal disease are the most common oral infections affecting a wide range of the population worldwide. The present study investigated the effects of two tart cherry (Prunus cerasus L.) fractions on important oral pathogens, including Candida albicans, Streptococcus mutans, and Fusobacterium nucleatum, as well as on the barrier function of oral epithelial cells. Procyanidins and quercetin and its derivatives were the most important constituents found in the tart cherry fractions. Although the fractions showed poor antimicrobial activity, they inhibited biofilm formation by the three oral pathogens in a dose‐dependent manner. The tart cherry fractions also attenuated the adherence of C. albicans and S. mutans to a hydroxylapatite surface as well as the adherence of F. nucleatum to oral epithelial cells. Treating oral epithelial cells with the tart cherry fractions significantly enhanced the barrier function as determined by monitoring the transepithelial electrical resistance. In conclusion, this study showed that the tart cherry fractions and their bioactive constituents could be promising antiplaque compounds by targeting biofilm formation and adherence properties of oral pathogens. Furthermore, its property of increasing the epithelial barrier function may protect against microbial invasion of the underlying connective tissue.

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Section: Discussionmentioning

confidence: 99%

Tart cherry (Prunus cerasus L.) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function

Lagha

LeBel

Grenier

2019

Phytotherapy Research

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“…; Venkatesan et al . ). The bacteria are able to produce an extracellular matrix around the bacterial cells and use it to adhere onto surfaces (Ribeiro et al .…”

Section: Introductionmentioning

confidence: 97%

“…Thus, biofilm formation should be considered targets for the design of new antibacterial drugs able to impair biofilm development (Venkatesan et al . ).…”

Section: Introductionmentioning

confidence: 97%

Searching for a potential antibacterial lead structure against bacterial biofilms among new naphthoquinone compounds

et al. 2017

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“…In case of confirmation of these preliminary data on a wider number of strains of staphylococcus, the fusidic acid not only shows a good activity on staphylococcus (MRSA, MSSA, MRSE and MSSE), but it should be also able to eradicate microorganisms persistent into the biofilm, to prevent any possible relapses .…”

Section: Fusidic Acid In the Treatment Of Skin Infections Caused By Smentioning

confidence: 78%

Fusidic acid betamethasone lipid cream

et al. 2016

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Bacterial infections of the skin and soft tissues are frequent disorders. They can be primitive infections (e.g. impetigo, folliculitis) or secondary infections complicating other diseases, particularly atopic dermatitis. The most common aetiologic agent is Staphylococcus aureus. Topical antibiotic therapy may be sufficient in many instances to control these infections. Fusidic acid is an antibiotic used topically on the skin which is very active against S. aureus, including methicillin-resistant strains, and other Gram-positive bacteria. Resistance rates to fusidic acid are stably low. A fusidic acid and betamethasone formulation in a lipid-enriched cream (lipid cream) has been recently developed in order to provide effective antibacterial and anti-inflammatory activities in conjunction with a powerful emollient and moisturising effect. This preparation may be especially useful in patients with atopic-infected eczema.

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Bacterial Resistance in Biofilm-Associated Bacteria

Cited by 173 publications

References 25 publications

Tart cherry (Prunus cerasus L.) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function

Tart cherry (Prunus cerasus L.) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function

Searching for a potential antibacterial lead structure against bacterial biofilms among new naphthoquinone compounds

Fusidic acid betamethasone lipid cream

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