Fusidic acid betamethasone lipid cream

Abstract

Bacterial infections of the skin and soft tissues are frequent disorders. They can be primitive infections (e.g. impetigo, folliculitis) or secondary infections complicating other diseases, particularly atopic dermatitis. The most common aetiologic agent is Staphylococcus aureus. Topical antibiotic therapy may be sufficient in many instances to control these infections. Fusidic acid is an antibiotic used topically on the skin which is very active against S. aureus, including methicillin-resistant strains, and other Gram-positive bacteria. Resistance rates to fusidic acid are stably low. A fusidic acid and betamethasone formulation in a lipid-enriched cream (lipid cream) has been recently developed in order to provide effective antibacterial and anti-inflammatory activities in conjunction with a powerful emollient and moisturising effect. This preparation may be especially useful in patients with atopic-infected eczema.

Dissemination of macrolides, fusidic acid and mupirocin resistance among Staphylococcus aureus clinical isolates

“…As an effective antibiotic, FA is often used to treat diseases, including skin and soft tissue infections, acute osteomyelitis, septic arthritis and other device related infections, which are caused by S. aureus [ 5 ]. Being extracted from cultures of fusidium coccineum , FA inhibits bacterial protein synthesis by preventing the turnover of fusA encoded elongation factor G (EF-G) from the ribosome [ 6 , 7 ]. Point mutations in this chromosomal gene usually lead to the high level resistance of FA [ 8 ].…”

Unearthing Novel Thiazolidinone Building Blocks As Carboxylic Acid Bioisosteres

“…This functional group is part of a diverse family of drugs, exemplified by the fact that a significant number (>450) of marketed drugs are carboxylic acid containing molecules [1a]. Example drugs include nonsteroidal anti-inflammatory drugs (NSAIDs), -lactam antibiotics [2], anticoagulants such as aspirin (which contains salicylic acid) and the eczema/dermatitis treatment betafucin (which contains fusidic acid) [3]. Nevertheless, despite the success of some carboxylic acid-containing drugs, the presence of this polar moiety can often be a disadvantage [4].…”