Bacterial Probiotics their Importances and Limitations: A Review

Ayichew, T; Belete, Anteneh; Alebachew, T; Tsehaye, H; H, Berhanu; Minwuyelet, A

doi:10.15744/2393-9060.4.202

Cited by 16 publications

(2 citation statements)

References 25 publications

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“…Currently the United States Food and Drug Administration (US FDA) has approved a select list of probiotics, which are known to be considered as safe for commercial use in food and in probiotic supplements (Bhadoria and Mahapatra, 2001). However, the FDA has not approved any claims for probiotics that relate them to a reduction in the risk of disease or as a viable treatment for extant medical conditions (Teshale et al, 2017). Indeed, in addition to the numerous health benefits of probiotics there are risks and uncertainties associated with their use.…”

Section: Limitations Of Probiotics Prebiotics and Synbiotics As Thermentioning

confidence: 99%

“…Indeed, in addition to the numerous health benefits of probiotics there are risks and uncertainties associated with their use. Numerous reports have connected probiotic use to deleterious effects including sepsis, immunoreactivity, and gene transfer resulting in pathogenic antibiotic resistance (Boyle et al, 2006;Teshale et al, 2017). These risks are of highest concern with respect to vulnerable groups including the elderly, critically ill and immunocompromised, making probiotic use in the context of pathology especially prone to complications.…”

Section: Limitations Of Probiotics Prebiotics and Synbiotics As Thermentioning

confidence: 99%

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The Microbiome and Alzheimer’s Disease: Potential and Limitations of Prebiotic, Synbiotic, and Probiotic Formulations

Arora

Green

Prakash

2020

Front. Bioeng. Biotechnol.

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The Microbiome has generated significant attention for its impacts not only on gastrointestinal health, but also on signaling pathways of the enteric and central nervous system via the microbiome gut–brain axis. In light of this, microbiome modulation may be an effective therapeutic strategy for treating or mitigating many somatic and neural pathologies, including neurodegenerative disorders. Alzheimer’s disease (AD) is a chronic neurodegenerative disease that interferes with cerebral function by progressively impairing memory, thinking and learning through the continuous depletion of neurons. Although its etiopathogenesis remains uncertain, recent literature endorses the hypothesis that probiotic, prebiotic and synbiotic supplementation alters AD-like symptoms and improves many of its associated disease biomarkers. Alternatively, a dysfunctional microbiota impairs the gut epithelial barrier by inducing chronic gastric inflammation, culminating in neuroinflammation and accelerating AD progression. The findings in this review suggest that probiotics, prebiotics or synbiotics have potential as novel biological prophylactics in treatment of AD, due to their anti-inflammatory and antioxidant properties, their ability to improve cognition and metabolic activity, as well as their capacity of producing essential metabolites for gut and brain barrier permeability.

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Section: Limitations Of Probiotics Prebiotics and Synbiotics As Thermentioning

confidence: 99%

Section: Limitations Of Probiotics Prebiotics and Synbiotics As Thermentioning

confidence: 99%