Bacterial pathogenicity

Ala’Aldeen, Dlawer A. A.; Wooldridge, Karl G.

doi:10.1016/b978-0-7020-4089-4.00028-7

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…Also, afimbrial or nonfimbrial adhesins (including protein or polysaccharide structures that are surface exposed on the bacterial cell and/or secreted) can influence adhesion. [27] All types of appendages play crucial roles in different dynamic aspects of bacterial mechanical properties and adhesion interactions. [22,24,24,[28][29][30][31] Similarly, the role of extracellular polymeric substances (EPS) on bacteria has been studied and shown to influence the adhesion mechanisms of EPS-producing bacteria in comparison with non-EPS-producing bacteria.…”

Section: Introductionmentioning

confidence: 99%

QCM‐D Viscoelastic and Adhesion Monitoring Facilitate Label‐Free and Strain‐Selective Bacterial Discrimination

Yongabi,

Khorshid,

Korbas

et al. 2023

Physica Status Solidi (a)

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Discriminating bacterial adhesion profiles at strain‐specific level is crucial for simulating and predicting infections and persistence, as well as developing more efficient antibacterial therapies. Herein, it is proposed that label‐ and receptor‐free bacterial discrimination can be achieved by dynamic viscoelastic and adhesion monitoring over specified timescales using the quartz crystal microbalance with dissipation monitoring (QCM‐D). Using two closely related E. coli strains, ATCC 8739 and JM109(DE3), it is shown that their viscoelastic and adhesion properties evolve in time through strain‐specific profiles that are clearly distinguishable over a period of 3–4 h. In addition, the viscoelasticity of both E. coli strains shows a strong strain‐specific dependence on the medium ionic strength, allowing to further amplify the differences in the bacterial adhesion signatures. Furthermore, the viscoelastic and adhesion behaviors of the two E. coli strains with two additional bacteria, Citrobacter freundii and Serratia marcescens, are compared. For all four bacteria, distinct viscoelastic profiles and adhesion fingerprints emerge over similar timescales that allow to reliably discriminate the various bacteria. These results and similar studies on other bacteria might have pharmacological benefits, for instance, by highlighting the role of bacterial–substrate adhesion and viscoelastic properties on disease pathogenesis and persistence, toward developing more effective therapies.

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Section: Introductionmentioning

confidence: 99%

QCM‐D Viscoelastic and Adhesion Monitoring Facilitate Label‐Free and Strain‐Selective Bacterial Discrimination

Yongabi,

Khorshid,

Korbas

et al. 2023

Physica Status Solidi (a)

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“…However, some exotoxins are unleashed following autolysis or upon antibiotics-induced bacteriolysis [9]. According to their main mechanism of action, exotoxins can be classified into three major groups, i.e., (1) membrane acting, (2) membrane damaging, and (3) intracellular effectors [10]. Membrane acting toxins bind to specific receptors on the surface of host cells and subsequently transduce transmembrane signals [10].…”

Section: Introductionmentioning

confidence: 99%

“…According to their main mechanism of action, exotoxins can be classified into three major groups, i.e., (1) membrane acting, (2) membrane damaging, and (3) intracellular effectors [10]. Membrane acting toxins bind to specific receptors on the surface of host cells and subsequently transduce transmembrane signals [10]. Membrane damaging toxins form pores or disrupt lipid bilayers to manipulate ion homeostasis, as such launching pathways involved in cell death and barrier dysfunction, like Ca 2+ [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Membrane acting toxins bind to specific receptors on the surface of host cells and subsequently transduce transmembrane signals [10]. Membrane damaging toxins form pores or disrupt lipid bilayers to manipulate ion homeostasis, as such launching pathways involved in cell death and barrier dysfunction, like Ca 2+ [10,11]. Intracellular effector toxins manipulate target molecule(s) by translocating an active enzymatic component into the cell [10].…”

Section: Introductionmentioning

confidence: 99%

“…Membrane damaging toxins form pores or disrupt lipid bilayers to manipulate ion homeostasis, as such launching pathways involved in cell death and barrier dysfunction, like Ca 2+ [10,11]. Intracellular effector toxins manipulate target molecule(s) by translocating an active enzymatic component into the cell [10]. All of these mechanisms may be involved in bacterial toxin-induced lung injury.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Bacterial Toxins in the Lungs

Lucas

Hadizamani

Gonzales

et al. 2020

Toxins

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Bacterial toxins play a key role in the pathogenesis of lung disease. Based on their structural and functional properties, they employ various strategies to modulate lung barrier function and to impair host defense in order to promote infection. Although in general, these toxins target common cellular signaling pathways and host compartments, toxin- and cell-specific effects have also been reported. Toxins can affect resident pulmonary cells involved in alveolar fluid clearance (AFC) and barrier function through impairing vectorial Na+ transport and through cytoskeletal collapse, as such, destroying cell-cell adhesions. The resulting loss of alveolar-capillary barrier integrity and fluid clearance capacity will induce capillary leak and foster edema formation, which will in turn impair gas exchange and endanger the survival of the host. Toxins modulate or neutralize protective host cell mechanisms of both the innate and adaptive immunity response during chronic infection. In particular, toxins can either recruit or kill central players of the lung’s innate immune responses to pathogenic attacks, i.e., alveolar macrophages (AMs) and neutrophils. Pulmonary disorders resulting from these toxin actions include, e.g., acute lung injury (ALI), the acute respiratory syndrome (ARDS), and severe pneumonia. When acute infection converts to persistence, i.e., colonization and chronic infection, lung diseases, such as bronchitis, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) can arise. The aim of this review is to discuss the impact of bacterial toxins in the lungs and the resulting outcomes for pathogenesis, their roles in promoting bacterial dissemination, and bacterial survival in disease progression.

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Recent Trends in the Analysis of Lipids, Carbohydrates, and Proteins in Food by Capillary Electrophoresis

Oliveira

Campos

Souza

et al. 2022

Current and Future Developments in Food Science

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Highly selective and sensitive analytical methods are necessary for food analysis because diverse components can be found in this complex sample matrix, sometimes occurring at only trace levels. Besides, simple and cost-effective methods are needed to meet the requirements of governmental food standards organizations and industries. Capillary Electrophoresis (CE) is a technique that meets these requirements offering high-resolution separations and high-throughput. It only demands small amounts of samples and chemicals for experiments and its versatility due to the different separation modes possible and the combination with different detection systems, has favored its application to determine diverse compounds in food analysis. This chapter summarizes significant issues and challenges involved in the determination of lipids, carbohydrates, and proteins, as well as recent advances in the analysis of these food components by several CE modes and detection systems.

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Bacterial pathogenicity

Cited by 6 publications

References 24 publications

QCM‐D Viscoelastic and Adhesion Monitoring Facilitate Label‐Free and Strain‐Selective Bacterial Discrimination

QCM‐D Viscoelastic and Adhesion Monitoring Facilitate Label‐Free and Strain‐Selective Bacterial Discrimination

Impact of Bacterial Toxins in the Lungs

Recent Trends in the Analysis of Lipids, Carbohydrates, and Proteins in Food by Capillary Electrophoresis

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