Bacterial neuraminidase inhibition by phenolic compounds from Usnea longissima

Ullah, Mahboob; Uddin, Zia; Song, Yeong Hun; Li, Z.P.; Kim, Jae-Yeon; Ban, Yeong Jun; Park, K.H.

doi:10.1016/j.sajb.2018.10.020

Cited by 12 publications

(7 citation statements)

References 17 publications

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“…Previously, various studies focused on U. longissima to explore its secondary metabolites . To the best of our knowledge, the physicochemical properties and biological activities of the graded ethanol-fractionated U.…”

Section: Introductionmentioning

confidence: 67%

Physicochemical Properties and Skin Protection Activities of Polysaccharides from Usnea longissima by Graded Ethanol Precipitation

Yang

Yue

et al. 2021

ACS Omega

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Four Usnea longissima polysaccharides (ULPs; ULP15, ULP30, ULP50, and ULP70) were obtained from the lichen U. longissima via water extraction and graded ethanol precipitation. The obtained ULPs were all heteropolysaccharides with a few proteins, with which glucose was the major monosaccharide composition. With the increase in the precipitated ethanol concentrations, the content of galactose, xylose, and mannose increased, whereas that of glucose decreased. Moreover, the antioxidant activity test demonstrated that ULP15 exhibited better reducing power and stronger scavenging ability on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl free radicals. Importantly, ULP15 also had a better proliferative effect on human HaCaT keratinocytes and dermal fibroblasts. Meanwhile, ULP15 protected HaCaT keratinocytes from UVB-induced proliferation inhibition and exhibited tyrosinase inhibition activity. Therefore, this work provides interesting insight into the preparation of cosmetic ingredients using the polysaccharide ULP15.

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Section: Introductionmentioning

confidence: 67%

Physicochemical Properties and Skin Protection Activities of Polysaccharides from Usnea longissima by Graded Ethanol Precipitation

Yang

Yue

et al. 2021

ACS Omega

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“…In addition, prenylated isoflavone and chromenone derivatives obtained from Flemingia philippinensis exhibit significant inhibition against bacterial sialidase. Park et al reported phenolic metabolite Evernic acid (Figure c), isolated from the methanol extract of Usnea longissimi, displayed dose-dependent inhibition against bacterial sialidase . Interestingly, artocarpin and katsumadain A show inhibitory activity against both influenza and S.…”

Section: Discussionmentioning

confidence: 99%

“…Park et al reported phenolic metabolite Evernic acid ( Figure 8 c), isolated from the methanol extract of Usnea longissimi , displayed dose-dependent inhibition against bacterial sialidase. 239 Interestingly, artocarpin and katsumadain A show inhibitory activity against both influenza and S. pneumoniae sialidases. 240 Other curcumin and flavanoid derivatives were explored as bacterial sialidase inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Sialidase Inhibitors with Different Mechanisms

et al. 2022

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Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus often involved in biological pathways. Inhibition of sialidases with inhibitors is an important approach for understanding sialidase function and the underlying mechanisms and could serve as a therapeutic approach as well. Transition-state analogues, such as anti-influenza drugs oseltamivir and zanamivir, are major sialidase inhibitors. In addition, difluoro-sialic acids were developed as mechanism-based sialidase inhibitors. Further, fluorinated quinone methide-based suicide substrates were reported. Sialidase product analogue inhibitors were also explored. Finally, natural products have shown competitive inhibiton against viral, bacterial, and human sialidases. This Perspective describes sialidase inhibitors with different mechanisms and their activities and future potential, which include transition-state analogue inhibitors, mechanism-based inhibitors, suicide substrate inhibitors, product analogue inhibitors, and natural product inhibitors.

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“…Usnea is a kind of lichen traditional Chinese medicine with highmedicinal value, distributed in polar and tropical regions, and widely distributed in Sichuan, Inner Mongolia, Yunnan, Heilongjiang, and other places in China. There are more than 10 common species, such as U. diffracta Vain, U. cavernosa Tuck, and U. longissima Ach, among which U. longissima Ach is a large species studied widely (Salgado et al, 2018;Ullah et al, 2019). The phytochemistry of the Usnea genus show that it contains more than 60 compounds, which mainly belong to depsides, depsidones, depsones, lactones, quinones, phenolics, polysaccharides, fatty acids, and dibenzofurans (Salgado et al, 2018).…”

Section: Molecular Docking Studymentioning

confidence: 99%

Phytochemical composition, antimicrobial activities, and cholinesterase inhibitory properties of the lichen Usnea diffracta Vain

Hao

Yan²,

Zhang³

et al. 2023

Front. Chem.

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Lichens are important sources of versatile bioactive compounds. Two new dibenzofurans (1–2), a multi-substituted single benzene ring (3), and two organic acid compounds (4–5) along with 25 known compounds (6–30) were isolated from the lichen Usnea diffracta Vain. Their structures were identified by physicochemical properties and spectral analyses. Compounds 1–30 were tested for inhibitory activities against Staphylococcus aureus, Escherichia coli, and Candida albicans by the disk diffusion method and microdilution assay respectively. Compound 3 showed moderate inhibitory activities against S. aureus and E. coli with the inhibition zone (IZ) of 6.2 mm and 6.3 mm, respectively. Depside 10 exhibited good activity against S.aureus and C. albicans with 6.6 mm and 32 μg/ml, respectively. The acetylcholinesterase inhibitory activities of compounds 1, 2, and 6–8 with the characteristic dibenzofuran scaffold were evaluated var anti-AChE assay and a molecular docking study. Compound 2 could better inhibit AChE at the concentration of 0.3 μmol/ml with a value of 61.07 ± 0.85%. The molecular docking study also demonstrated that compound 2 had the strongest binding affinity among the five dibenzofurans, and the “-CDOCKER Energy” value was 14.4513 kcal/mol.

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Bacterial neuraminidase inhibition by phenolic compounds from Usnea longissima

Cited by 12 publications

References 17 publications

Physicochemical Properties and Skin Protection Activities of Polysaccharides from Usnea longissima by Graded Ethanol Precipitation

Physicochemical Properties and Skin Protection Activities of Polysaccharides from Usnea longissima by Graded Ethanol Precipitation

Sialidase Inhibitors with Different Mechanisms

Phytochemical composition, antimicrobial activities, and cholinesterase inhibitory properties of the lichen Usnea diffracta Vain

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