Bacterial melanin increases electrical activity of neurons in Substantia Nigra pars compacta

Petrosyan, Tigran; Chavushyan, V. A.; Hovsepyan, A. S.

doi:10.1007/s00702-013-1095-9

Cited by 6 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The firing rate of substantia nigra pars compacta dopaminergic neurons is significantly increased by bacterial melanin. An increase in the firing rate of substantia nigra neurons can aid in the recovery of the substantia nigra after neuronal degeneration [ 29 ].…”

Section: Applications Of Melaninmentioning

confidence: 99%

Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source

El‐Naggar

Saber

2022

Polymers

View full text Add to dashboard Cite

Melanin is a universal natural dark polymeric pigment, arising in microorganisms, animals, and plants. There is a couple of pieces of literature on melanin, each focusing on a different issue, the goal of the present review is to focus on microbial melanin. It has numerous benefits with very few drawbacks. The current situation and expected trends are discussed. Intriguing, numerous studies have provoked a serious necessity for a comprehensive assessment of microbial melanin pigments. So that, such review would help scholars from diverse backgrounds to realize the importance of melanin pigments isolated from microorganisms, with this aim in mind, information, and hypothesis from this review could be the paradigm for studies on melanin in the next era.

show abstract

Section: Applications Of Melaninmentioning

confidence: 99%

Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source

El‐Naggar

Saber

2022

Polymers

View full text Add to dashboard Cite

show abstract

“…In a previous experimental series, we have shown the neuroprotective action of BM after neurotrauma in the CNS in that BM accelerates motor recovery and enhances regeneration after substantia nigra lesions [ 22 ]. Injection of BM increases electrical activity of substantia nigra dopaminergic neurons [ 23 ], although it remained unclear whether the BM is able to cross the BBB or not. The goal of the present study was to test the ability of BM to cross the BBB using the method of radioactive labelling.…”

Section: Introductionmentioning

confidence: 99%

Bacterial melanin crosses the blood–brain barrier in rat experimental model

Petrosyan¹,

Hovsepyan

2014

Fluids Barriers CNS

View full text Add to dashboard Cite

BackgroundBacterial melanin has been proven to stimulate regeneration after CNS lesions. The purpose of this study was to test, whether bacterial melanin can enter the brain via the blood–brain barrier (BBB).MethodsBacterial melanin (BM) was radioactively labeled by the iodobead method and used to test the BBB permeability after systemic injection into rats. The unidirectional influx rate from the blood was calculated by multiple-time regression analysis. A subgroup of the animals was co-injected with non-labeled BM to determine if BM has a saturable transport across the BBB. The levels of radioactivity were determined in the serum and tissues. Arterial blood was sampled to obtain the level of I-BM at different time points after injection. After systemic perfusion with saline, animals were decapitated and brain, spinal cord, liver and kidney samples were obtained and homogenized to test the I-BM level.ResultsStudy results showed that radioactively-labeled bacterial melanin crossed the BBB, was enzymatically stable in blood and in brain parenchyma. Entry to brain was reduced when non-labeled BM was also present. Circulating melanin entered all regions of the CNS but the uptake was higher in lumbar spinal cord, thalamus, hypothalamus and substantia nigra. Liver and kidneys had high uptake rates of BM.ConclusionsThese results show that bacterial melanin has saturable transport across the BBB and selectively targets some CNS regions. Such transport may contribute to the neuroprotective action of bacterial melanin.

show abstract

“…BM has been tested previously as a neuroprotector that significantly accelerates motor recovery after CNS lesions (Azaryan, Petrosyan, Popov, & Martirosyan, 2004;Fanardjian et al, 2001;Gevorkyan, Meliksetyan, Hoysepyan, & Sagiyan, 2007;Popov, 2003;Sarkisyan et al, 2007). BM increases electrical activity of neurons in SNc (Petrosyan, Chavushyan, & Hovsepyan, 2013). It increases the rate of excitatory responses after high frequency tetanic stimulation of ipsilateral caudate-putamen.…”

mentioning

confidence: 99%

Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

Petrosyan¹,

Gevorkyan

Hovsepyan

2013

Journal of Motor Behavior

Self Cite

View full text Add to dashboard Cite

Sixteen adult male rats were initially trained to an instrumental conditioned reflex (ICR) and subjected to unilateral destruction of substantia nigra pars compacta. Part of the animals was injected with bacterial melanin solution on the next day of destruction. The other 8 rats served as the control group. Recovery rates for ICR and dynamics of paralyzed hindlimb movements were studied in both groups. Conditioned reflex and contralateral to lesion hindlimb movements recovered faster in rats injected with bacterial melanin after the destruction.

show abstract

Bacterial melanin increases electrical activity of neurons in Substantia Nigra pars compacta

Cited by 6 publications

References 15 publications

Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source

Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source

Bacterial melanin crosses the blood–brain barrier in rat experimental model

Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

Contact Info

Product

Resources

About