Bacterial-mediated DNA delivery to tumour associated phagocytic cells

Byrne, William L.; Murphy, C.; Cronin, Michelle; Wirth, Timo; Tangney, Mark

doi:10.1016/j.jconrel.2014.10.030

Cited by 17 publications

(14 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complementary to the studies focusing directly on tumors, Byrne et al looked at the feasibility of engineering bacteria-mediated DNA constructs for drug delivery to tumorassociated phagocytic cells [143]. Host immune cells, including macrophages, dendritic cells, and neutrophils, are known to play a negative role in many diseases, such as cancer.…”

Section: Engineered Therapeutic Bacteriathe Future Of Bacterial Cance...mentioning

confidence: 99%

“…For instance, macrophages exhibit a strong pathophysiological role in several pathologies and are often targeted by diverse therapeutics. Knowing that non-pathogenic bacteria cannot enter host cells, except for phagocytes, the authors used that specificity to engineer a non-invasive E. coli stain, capable of passively transfecting specific genomic content inside tumorassociated phagocytic cells [143]. Using an in vitro differentiated human monocyte cell line, as well as two in vivo mouse models (an ovarian cancer ascites and a solid colon tumor model), Byrne et al efficiently delivered transgene-loaded bacteria to tumor regions.…”

Section: Engineered Therapeutic Bacteriathe Future Of Bacterial Cance...mentioning

confidence: 99%

See 1 more Smart Citation

The intratumoral microbiome: Characterization methods and functional impact

Heymann¹,

Bard²,

Heymann³

et al. 2021

Cancer Letters

View full text Add to dashboard Cite

Section: Engineered Therapeutic Bacteriathe Future Of Bacterial Cance...mentioning

confidence: 99%

Section: Engineered Therapeutic Bacteriathe Future Of Bacterial Cance...mentioning

confidence: 99%

The intratumoral microbiome: Characterization methods and functional impact

Heymann¹,

Bard²,

Heymann³

et al. 2021

Cancer Letters

View full text Add to dashboard Cite

“…Given their unique capacity for selective growth in tumor tissue, therapeutics may be locally produced within the tumor by administered engineered bacteria (28)(29)(30)(31)(32)(33)(34). Bacteria can also be engineered to "sense" their environment, using synthetic biology approaches, further increasing their therapeutic or diagnostic power (35)(36)(37).…”

Section: Bacteria As Therapeutic Agentsmentioning

confidence: 99%

Sequence-Based Characterization of Intratumoral Bacteria—A Guide to Best Practice

2020

View full text Add to dashboard Cite

Tumors are hospitable environments to bacteria and several recent studies on cancer patient samples have introduced the concept of an endogenous tumor microbiome. For a variety of reasons, this putative tumor microbiome is particularly challenging to investigate, and a failure to account for the various potential pitfalls will result in erroneous results and claims. Before this potentially extremely medically-significant habitat can be accurately characterized, a clear understanding of all potential confounding factors is required, and a best-practice approach should be developed and adopted. This review summarizes all of the potential issues confounding accurate bacterial DNA sequence analysis of the putative tumor microbiome, and offers solutions based on related research with the hope of assisting in the progression of research in this field.

show abstract

“…Although some of these organisms are used as monotherapy [6,8,24], most of them are used as vehicles to deliver therapeutic agents such as DNA [19], siRNA [9,28], toxins [7, 10-12, 20, 30], and prodrug-enzymes [13], or combined with other therapies [14,15,21,32] to enhance their therapeutic effect.…”

Section: Cancer Treatment Strategies Based On the Use Of Bacteriamentioning

confidence: 99%

Salmonella-Mediated Cancer Therapy: Roles and Potential

Nguyen

Min

2016

Nucl Med Mol Imaging

View full text Add to dashboard Cite

The use of bacteria for cancer therapy, which was proposed many years ago, was not recognized as a potential therapeutic strategy until recently. Technological advances and updated knowledge have enabled the genetic engineering of bacteria for their safe and effective application in the treatment of cancer. The efficacy of radiotherapy depends mainly on tissue oxygen levels, and low oxygen concentrations in necrotic and hypoxic regions are a common cause of treatment failure. In addition, the distribution of a drug is important for the therapeutic effect of chemotherapy, and the poor vasculature in tumors impairs drug delivery, limiting the efficacy of a drug, especially in necrotic and hypoxic regions. Bacteria-mediated cancer therapy (BMCT) relies on facultative anaerobes that can survive in well or poorly oxygenated regions, and it therefore improves the therapeutic efficacy drug distribution throughout the tumor mass. Since the mid-1990s, the number of published bacterial therapy papers has increased rapidly, with a doubling time of 2.5 years in which the use of increased significantly. BMCT is being reevaluated to overcome some of the drawbacks of conventional therapies. This review focuses on-mediated cancer therapy as the most widely used type of BMCT.2.

show abstract

Bacterial-mediated DNA delivery to tumour associated phagocytic cells

Cited by 17 publications

References 51 publications

The intratumoral microbiome: Characterization methods and functional impact

The intratumoral microbiome: Characterization methods and functional impact

Sequence-Based Characterization of Intratumoral Bacteria—A Guide to Best Practice

Salmonella-Mediated Cancer Therapy: Roles and Potential

Contact Info

Product

Resources

About