Bacterial infections post-living-donor liver transplantation in Egyptian hepatitis C virus-cirrhotic patients: A single-center study

Montasser, Mohamed F.; Abdelkader, Nadia Abdelaaty; Abdelhakam, Sara M.; Dabbous, Hany; Montasser, Iman Fawzy; Massoud, Yasmine Mahmoud; Abdelmoaty, Waleed; Saleh, Shereen A.; Bahaa, Mohamed; Said, Hazem; El-Meteini, Mahmoud

doi:10.4254/wjh.v9.i20.896

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…In our study, 58.3% of infection attacks were sourced by the hepatobiliary system (cholangitis, intraabdominal abscess, infected biloma, and pancreatitis). Nosocomial MDR gram‐negative microorganisms predominate an infections originating from the hepatobiliary system 26 . Particularly high mortality rates, in the range of ~35%‐70%, are reported for patients developing infections with MDR microorganisms, such as ESBL‐producing or carbapenem‐resistant Enterobacteriaceae.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of clinical characteristics and outcomes of postoperative ınfections in living liver donors

et al. 2021

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Aim:To analyze developing infections after living donor hepatectomy (LDH) in living liver donors (LLDs).Methods: Demographic and clinical characteristics of 1106 LLDs were retrospectively analyzed in terms of whether postoperative infection development. Therefore, LLDs were divided into two groups: with (n = 190) and without (n = 916) antimicrobial agent use. Results:The median age was 29.5 (min-max: 18-55). A total of 257 (23.2%) infection attacks (min-max: 1-8) was developed in 190 (17.2%) LLDs. The patients with the infection that were longer intensive care unit (ICU) and hospital stays, higher hospital admissions, emergency transplantation, invasive procedures for ERCP, PTC biloma, and abscess drainage, and the presence of relaparatomies and transcystic catheters. Infection attacks are derived from a 58.3% hepatobiliary system, 13.2% urinary system, 6.6% surgical site, and 5.8% respiratory system. The most common onset symptoms were fever, abdominal pain, nausea, and vomiting. A total of 125 positive results was detected from 77 patients with culture positivity. The most detected microorganisms from the cultures taken are Extended-Spectrum β-lactamases (ESBL) producing Klebsiella pneumonia (16.8%) and Escherichia coli (16%), Methicillin-Resistant Staphylococcus aureus [(MRSA) (9.6%)], Methicillin-susceptible S aureus [(MSSA) (9.6%)], and Pseudomonas aeruginosa (8.8%), respectively. The average number of ICU hospitalization days was 3 ± 2 (min 1-max 30, IQR:1) and hospitalization days was 14 ± 12 (min 3-max 138, IQR: 8). All infection attacks were successfully treated. No patients died because of infection or another surgical complication. Conclusion:Infections commonly observed infected biloma, cholangitis, and abscess arising from the biliary system and other nosocomial infections are the feared complications in LLDs. These infections should be managed multidisciplinary without delay and carefully.

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Section: Discussionmentioning

confidence: 99%

Evaluation of clinical characteristics and outcomes of postoperative ınfections in living liver donors

et al. 2021

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“…The cells were probed with fluorescent solution SA-FLOUS (Origin Biosciences Inc., Nanjing, China) after centrifugation. To assess cell apoptosis, the fluorescence was detected using a 620-nm bandpass filter for PI and a 525-nm bandpass filter for FITC at 488-nm excitation wavelength, respectively [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

LINC00221 silencing prevents the progression of hepatocellular carcinoma through let-7a-5p-targeted inhibition of MMP11

Yang

et al. 2021

Cancer Cell Int

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Background Microarray profiles of hepatocellular carcinoma (HCC) identified that long intergenic noncoding RNA 00221 (LINC00221) was upregulated. Herein, we aimed to identify the functional significance and underlying mechanisms of LINC00221 in HCC. Methods and results Human HCC samples had increased expression of LINC00221. Effects of LINC00221 on HCC cellular functions were analyzed using gain- and loss-function approaches. LINC00221 knockdown repressed HCC cell growth, migration, and invasion and enhanced their apoptosis. This anti-tumor effect was validated in vivo. Online prediction showed the potential binding relationship between LINC00221 and let-7a-5p, as well as that between let-7a-5p and matrix metalloproteinase 11 (MMP11). The results of luciferase, RNA immunoprecipitation, and RNA pull-down assays identified that LINC00221 interacted with let-7a-5p to increase expression of MMP11. Furthermore, we demonstrated that LINC00221 silencing increased let-7a-5p and inhibited MMP11 expression, thereby delaying the progression of HCC in vitro. Conclusions Silencing of LINC00221 could prevent HCC progression via upregulating let-7a-5p and downregulating MMP11. As such, LINC00221 inhibition presents a promising antitumor strategy for the treatment of HCC.

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“…Intra-abdominal infections were the most frequently encountered infection, of which Enterococcus species were the leading pathogens. Montasser et al [67] in the prospective study included 45 patients who underwent LDLT at Ain Shams Center for Organ Transplant, 33 patients (73.3%) were suffered from bacterial infections. The study done in National liver institute Menoufya in 2015 showed that the HCV recurrence was 19.2% [68].…”

Section: Pre-transplant Detection Of Active Bacterial Infectionmentioning

confidence: 99%

Infections in the solid-organ transplant recipients

Said

2021

Ukr. J. Nephrol. and Dial.

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The advancement in the field of transplant has led to the increasing number of solid-organ transplant recipients (SOTRs). This success leads to novel confronts in communicable infections, which are compound by the emergence of newly contagious and antimicrobial drugs resistant microorganisms. The prevention of infections is a cornerstone of any modern solid organ transplantation program. Understanding the fundamentals of these infections with early detection is crucial for improving the outcomes of such patients and lowers the probable extra complications. The probability of critical infections in SOTRs is established by relations between the patient’s epidemiological exposures and the net condition of immune repression. A timeline was formed to build up a discrepancy diagnosis of infection in SORTs. The improvement in screening, the investigations including imaging and molecular techniques and prophylactic intervention protocols, has made it promising to limit the penalty of infections and act towards better patient endurance. Pre-transplant screening of the prospective organ donor and recipient provides a chance to evaluate the viability and wellbeing of transplantation, to decide the prophylaxis and protective approaches developed post-transplant, to find out and entirely treat active infection in the possible recipient proceeding to transplant, to renovate the vaccination condition of the potential recipient.

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Bacterial infections post-living-donor liver transplantation in Egyptian hepatitis C virus-cirrhotic patients: A single-center study

Cited by 9 publications

References 17 publications

Evaluation of clinical characteristics and outcomes of postoperative ınfections in living liver donors

Evaluation of clinical characteristics and outcomes of postoperative ınfections in living liver donors

LINC00221 silencing prevents the progression of hepatocellular carcinoma through let-7a-5p-targeted inhibition of MMP11

Infections in the solid-organ transplant recipients

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