Bacterial infection in hospitalized patients of acute exacerbation of COPD and their relation to lung function: A prospective study

Sputum bacterial profile and antibiotics sensitivity pattern in acute exacerbation of chronic obstructive pulmonary disease

“…Erkan et al [17] reported that an infectious agent was identified in 61.3% of patients, either serologically or with sputum culture. Many other studies reported lower prevalence of bacterial etiology in AECOPD;50% [18] , 48.7 % [2] , 47.22% [19] ,37% [20] , and 34.7% [21] . Moghoofei et al [7] in their meta-analysis reported that he overall estimation of the prevalence of bacterial infection in AECOPD was 49.59%.…”

“…Moreover, one previous study reported approximately the same prevalence of P. aeruginosa (10.1%) [21] . Kuwal and Joshi [19] found that the P. aeruginosa was the most predominant organism (38.23%) followed by klebsiella (29.41%), S. aureus (23.53%), S. pneumoniae (5.88%) and acinetobacter (2.94%). Mangla et al [16] reported that 32% of cases were found to be infected with pseudomonas species, 12% of streptococcus pneumoniae, 6% streptococcus pyogenes, 8% klebsiella pneumoniae, 4% E. coli, 6% H. influenza.…”

“…Sharma et al [2] found that the growth percentage of a pathogenic organism was found to be highest (71.4%) in severe obstruction followed by moderate obstruction (55.9%) and least (35.2%) in mild obstruction cases (p = 0.004). Kuwal and Joshi [19] found that the gram-negative bacteria were dominating in patients with stage III and stage IV COPD. Abdallah et al [32] found that FEV 1 <35 % were significantly associated with negative-gram bacteria.…”