Bacterial Growth in Propofol

McLeod, Graeme; Pace, Nathan L.; Inglis, M.D.

doi:10.1093/bja/67.5.665-b

Cited by 22 publications

(12 citation statements)

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“…[32][33][34] The most probable explanation for this discrepancy is that a propofol syringe handled routinely in an operating theatre is naturally at a much greater risk of contami-nation than is a propofol syringe kept under sterile conditions in the laboratory. Accordingly, contamination frequencies comparable to those of the present study have been reported previously, not only for the anesthesia workplace 35,36 but also for intensive care units 37 during the routine use of propofol.…”

Section: Discussionmentioning

confidence: 99%

Le maniement d’usage du propofol prévient la contamination aussi effectivement que la stricte adhésion aux recommandations du fabricant

Lorenz

Kolbitsch

Lass‐Flörl

et al. 2002

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : Propofol is a potential vector of infection, because it contains no preservative. Thus, the manufacturer's specific recommendations for preparing injections or infusions go beyond the guidelines commonly used in our operating rooms for preparing other iv drugs. The purpose of the present study was to determine whether in the daily routine of an operating theatre a modified propofol handling technique can prevent contamination as effectively as do the manufacturer's handling recommendations. M Me et th ho od ds s: : A total of 160 consecutive neurosurgical patients were allocated to either Group I (manufacturer's handling recommendations: i.e., 1) disinfecting propofol vials and ampoules before filling syringes; 2) replacing empty syringes; 3) discarding all material at the end of surgery); or Group II (modified propofol handling protocol: i.e., 1) refilling empty syringes; 2) renewing only the infusion line to the patient). R Re es su ul lt ts s: : Total contamination rates were comparable in both groups (Group I: 14/160 (8.75%), Group II: 13/160 (8.13%) (P 2 =0.074; P=0.96). Frequency of contamination was not different between groups; either in sample 1 taken at the beginning of the procedure, (Group I: 5/80 (6.25%) vs Group II: 6/80 (7.5%); P 2 =0.098; P=0.76) or in sample 2, taken at the end, (Group I: 9/80 (11.25%) vs Group II: 7/80 (8.75%); P 2 =0.278; P=0.598). C Co on nc cl lu us si io on n: : We conclude that in the daily routine of the operating theatre following a modified propofol handling protocol prevents contamination of propofol syringes as effectively as does adhering to the manufacturer's specific handling recommendations. However, neither of the tested guidelines completely prevented contamination. Groupe I et 13/160 (8,13 %) dans le Groupe II (P 2 = 0,074; P = 0,96). La fréquence de contamination ne diffère pas d'un groupe à l'autre, pour l'échantillon 1 prélevé au début de l'opération (Groupe I : 5/80 (6,25 %) vs Groupe II : 6/80 (7,5 %); P 2 = 0,098; P = 0,76) ou l'échantillon 2 à la fin (Groupe I : 9/80 (11,25 %)vs Groupe II : 7/80 (8,75 %); P 2 = 0,278; P = 0,598 Objectif : Le propofol, ne contenant aucun agent de conservation, est un vecteur potentiel d'infection. C'est pourquoi les recommandations spécifiques du fabricant au sujet de la préparation d'injections ou de perfusions vont au delà des directives habituellement suivies dans nos salles d'opération pour la préparation d'autres médicaments intraveineux. Nous avons voulu déterminer si, en modifiant le maniement du propofol en salle d'opération, nous pouvions prévenir la contamination aussi efficacement qu'en suivant à la lettre les recom

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Section: Discussionmentioning

confidence: 99%

Le maniement d’usage du propofol prévient la contamination aussi effectivement que la stricte adhésion aux recommandations du fabricant

Lorenz

Kolbitsch

Lass‐Flörl

et al. 2002

Can J Anesth/J Can Anesth

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“…No bacterial growth was found when drugs were directly subplated to the medium under strict care using aseptic techniques. The bacteria that were investigated in the present study are associated with contamination [10][11][12].…”

Section: Discussionmentioning

confidence: 96%

“…There was also no difference between bacterial growth patterns when lipid emulsions were compared [11]. The source of contamination is consistently related to preparation of the solution and hand washing [12]; swabbing the ampule with alcohol before breaking [13] is important to prevent inoculation. No bacterial growth was found when drugs were directly subplated to the medium under strict care using aseptic techniques.…”

Section: Discussionmentioning

confidence: 96%

Antibacterial activity of remifentanil and mixtures of remifentanil and propofol

Apan

Sahin

et al. 2007

Journal of Clinical Anesthesia

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“…Propofol is shown to promote growth of bacteria and fungi (2)(3)(4). It has been suggested that bacterial contamination is extrinsic in nature, secondary to contamination during or after opening ampules of propofol (5,6). Nevertheless, two recent surveys of anesthesiologists have shown that aseptic technique is frequently not observed when handling propofol ampules (7,8).…”

mentioning

confidence: 99%

Growth of Escherichia coli in propofol, lidocaine, and mixtures of propofol and lidocaine

Sakuragi

Yanagisawa

Shirai

et al. 1999

Acta Anaesthesiol Scand

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Bacterial Growth in Propofol

Cited by 22 publications

References 0 publications

Le maniement d’usage du propofol prévient la contamination aussi effectivement que la stricte adhésion aux recommandations du fabricant

Le maniement d’usage du propofol prévient la contamination aussi effectivement que la stricte adhésion aux recommandations du fabricant

Antibacterial activity of remifentanil and mixtures of remifentanil and propofol

Growth of Escherichia coli in propofol, lidocaine, and mixtures of propofol and lidocaine

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