Growth of Escherichia coli in propofol, lidocaine, and mixtures of propofol and lidocaine

Abstract

Lidocaine possesses bacteriostatic activity against E. coli. Addition of lidocaine to propofol confers its bacteriostatic activity to the mixture and may decrease the hazard of infection associated with the extrinsic contamination of propofol.

Le maniement d’usage du propofol prévient la contamination aussi effectivement que la stricte adhésion aux recommandations du fabricant

“…1,5 The absence of preservatives in the propofol preparation may support microbial growth. [6][7][8][9][10][11][12][13][14] Admixture of thiopentone, 15 lidocaine [16][17][18][19] or disodium edetate 20 diminishes microbial growth in propofol, although microbial destruction is not achieved. Because of this risk, the manufacturer's specific recommendations (Fresenius Kabi Pharmaceutical.…”

The Accepted “Clinical Interaction Model”: A Special Case of Reality

“…Antimicrobial activity has been found in many other compounds including flavanones, isoflavones and prenylflavanones [37,38]; antihistamines [39,40], antihypertensive agent methyl-L-DOPA [41]; cardiovascular drugs oxyfedrine and dobutamine [42]; local and general anaesthetics [17,43,44] and barbiturates [45].…”

Bacteriostatic Effect of Mixtures of 1% Propofol with 4% Lidocaine versus 4% Lidocaine Alone: Regards on Microbiologic Studies in the Field of Anesthesiology

“…1 Hospitals provide care for the most medically vulnerable and immunocompromised individuals in society; however, despite governmental safety regulations and well-established safe food handling practices, foodborne outbreaks in healthcare settings do occur and are associated with an increased risk of death compared with other settings. 2 Listeria monocytogenes is uniquely suited to cause serious nosocomial infections, given its tendency to contaminate certain ready-to-eat food products, ability to replicate at refrigerator temperatures, and propensity to cause invasive infection in immunocompromised patients and pregnant women.…”

“…6 figure 1. Results adapted from the study by Sakuragi et al, 1 which represents the bacterial growth in the mixture of 4% lidocaine with 1% propofol (dashed line) and in 4% lidocaine alone (solid line). CFU, colony-forming unit.…”

“…When the authors counted the progress of colonies in 4% lidocaine with 1% propofol and 4% lidocaine, surprisingly the growth rate reported in the mixture was less than in the lidocaine alone (Ϫ0.004 and ϩ0.01, respectively). According to the results presented by Sakuragi et al, 1 we adapted them in Figure 1 to show the same amazing situation where the mixture of lidocaine with propofol reduces the bacterial growth in greater magnitude than lidocaine alone, especially after 20 hours. Although this observation might produce many questions, we confirm no statistically significant difference between the colony counts in the mixture and lidocaine alone (t test, P p .07).…”