Bacterial exposure to ZnO nanoparticles facilitates horizontal transfer of antibiotic resistance genes

Wang, Xiaolong; Yang, Fengxia; Zhao, Jing; Xu, Yan; Mao, Daqing; Zhu, Xiao; Luo, Yi; Alvarez, Pedro J. J.

doi:10.1016/j.impact.2017.11.006

Cited by 106 publications

(54 citation statements)

References 40 publications

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“…This type of exposure facilitated the conjugative transfer of antibiotic resistance plasmids. The exposure to sublethal concentrations of ZnO NPs increased the permeability of the cell membranes and this, in turn, increased the horizontal gene transfer frequency [54]. In a previous study Qiu et al also exposed E. coli to high concentrations of titanium dioxide nanoparticles (TiO 2 NPs), and observed that this caused a decrease in bacterial growth rate and an increase the conjugative transfer rate of antibiotic resistance genes [55].…”

Section: Defense Mechanisms Against Metal Ions Release From Metal mentioning

confidence: 99%

Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

Niño-Martínez

Orozco

Martínez-Castañón

et al. 2019

IJMS

204

125

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The increase in bacterial resistance to one or several antibiotics has become a global health problem. Recently, nanomaterials have become a tool against multidrug-resistant bacteria. The metal and metal oxide nanoparticles are one of the most studied nanomaterials against multidrug-resistant bacteria. Several in vitro studies report that metal nanoparticles have antimicrobial properties against a broad spectrum of bacterial species. However, until recently, the bacterial resistance mechanisms to the bactericidal action of the nanoparticles had not been investigated. Some of the recently reported resistance mechanisms include electrostatic repulsion, ion efflux pumps, expression of extracellular matrices, and the adaptation of biofilms and mutations. The objective of this review is to summarize the recent findings regarding the mechanisms used by bacteria to counteract the antimicrobial effects of nanoparticles.

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Section: Defense Mechanisms Against Metal Ions Release From Metal mentioning

confidence: 99%

Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

Niño-Martínez

Orozco

Martínez-Castañón

et al. 2019

IJMS

204

125

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“…Remarkably, the authors did not find any effect on conjugation frequency when bacteria were exposed to the same concentration of bulk alumina, suggesting a NP-specific effect [80]. Likewise, several studies have described enhanced conjugation transfer of ARGs in bacteria exposed to subinhibitory concentrations of Al2O3-NPs, ZnO-NPs, TiO2-NPs, and CuO-NPs, whereas bulk or ionic CuO, Al2O3, and TiO2 did not [80,[84][85][86]89].…”

Section: Arming the Enemy: Metallic Nps May Act As Pressure That Co-smentioning

confidence: 87%

“…Over the last years, several studies have found that exposure to sub-inhibitory levels of metallic NPs favors bacterial conjugation and transformation in laboratory cultures [80,82,84,85], natural environments [62,86], and human-made systems [87]. Different laboratories recently observed higher transformation frequency when bacteria were exposed to either ZnO-NP [86] or Al2O3-NPs [88]. Furthermore, a pioneer study [80] reported that low concentrations of Al2O3-NPs (nanoalumina) (up to 5 mM) promoted conjugative transfer of the multi-resistance plasmid RP4 between E. coli and Salmonella enteritidis.…”

Section: Arming the Enemy: Metallic Nps May Act As Pressure That Co-smentioning

confidence: 99%

Metallic Nanoparticles—Friends or Foes in the Battle against Antibiotic-Resistant Bacteria?

et al. 2021

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The rapid spread of antibiotic resistances among bacteria demands novel strategies for infection control, and metallic nanoparticles appear as promising tools because of their unique size and tunable properties that allow their antibacterial effects to be maximized. Furthermore, their diverse mechanisms of action towards multiple cell components have suggested that bacteria could not easily develop resistance against nanoparticles. However, research published over the last decade has proven that bacteria can indeed evolve stable resistance mechanisms upon continuous exposure to metallic nanoparticles. In this review, we summarize the currently known individual and collective strategies employed by bacteria to cope with metallic nanoparticles. Importantly, we also discuss the adverse side effects that bacterial exposure to nanoparticles may have on antibiotic resistance dissemination and that might constitute a challenge for the implementation of nanoparticles as antibacterial agents. Overall, studies discussed in this review point out that careful management of these very promising antimicrobials is necessary to preserve their efficacy for infection control.

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“…Additionally, sublethal concentrations select resistant phenotypes from mutations or horizontal gene transfer (HGT) that sometimes use mobile genetic elements (MGEs) (Kohanski et al, 2010;Baharoglu and Mazel, 2011;Gutierrez et al, 2013;Haaber et al, 2017;Lekunberri et al, 2017). The AR in the environment is a natural process but is also promoted by anthropogenic pollutants like antibiotics, biocides, heavy metals, hydrocarbons, pesticides, and nanomaterials, among others (Baker-Austin et al, 2006;Dealtry et al, 2014;Pal et al, 2015Pal et al, , 2017Chen et al, 2017;Poole, 2017;Wang et al, 2018;Nguyen et al, 2019). Therefore, naturally antibiotic-resistant bacteria (ARB) could be a prime source for antibiotic resistance genes (ARGs) found in pathogens as certain findings may indicate (Rodríguez et al, 2004;Poirel et al, 2005Poirel et al, , 2012Yang J. et al, 2013;Jiang et al, 2017), but may later have evolved and be selected.…”

Section: Introductionmentioning

confidence: 99%

Bacteria From the Multi-Contaminated Tinto River Estuary (SW, Spain) Show High Multi-Resistance to Antibiotics and Point to Paenibacillus spp. as Antibiotic-Resistance-Dissemination Players

2020

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Bacterial resistance to antibiotics is an ever-increasing phenomenon that, besides clinical settings, is generally assumed to be prevalent in environmental soils and waters. The analysis of bacteria resistant to each one of 11 antibiotics in waters and sediments of the Huelva's estuary, a multi-contaminated environment, showed high levels of bacteria resistant mainly to Tm, among others. To further gain knowledge on the fate of multi-drug resistance (MDR) in environmental bacteria, 579 ampicillinresistant bacteria were isolated tested for resistance to 10 antibiotics. 92.7% of the isolates were resistant to four or more antibiotic classes, indicating a high level of multi-resistance. 143 resistance profiles were found. The isolates with different MDR profiles and/or colony morphologies were phylogenetically ascribed based on 16S rDNA to phyla Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes, including 48 genera. Putative intrinsic resistance was detected in different phylogenetic groups including genera Altererythrobacter, Bacillus, Brevundimonas, Erythrobacter, Mesonia, Ochrobactrum, and Ponticaulis. Correlation of the presence of pairs of the non-intrinsicresistances in phylogenetic groups based on the kappa index (κ) highlighted the co-habitation of some of the tested pairs at different phylogenetic levels. Maximum correlation (κ = 1.

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Bacterial exposure to ZnO nanoparticles facilitates horizontal transfer of antibiotic resistance genes

Cited by 106 publications

References 40 publications

Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

Molecular Mechanisms of Bacterial Resistance to Metal and Metal Oxide Nanoparticles

Metallic Nanoparticles—Friends or Foes in the Battle against Antibiotic-Resistant Bacteria?

Bacteria From the Multi-Contaminated Tinto River Estuary (SW, Spain) Show High Multi-Resistance to Antibiotics and Point to Paenibacillus spp. as Antibiotic-Resistance-Dissemination Players

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