Bacterial epidemiology of osteoarticular infections in a referent center: 10-year study

Titécat, Marie; Senneville, Éric; Wallet, Frédéric; Dezèque, Hervé; Migaud, Henri; Courcol, René; Loïez, Caroline

doi:10.1016/j.otsr.2013.02.011

Cited by 58 publications

(37 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a sample of 65 patients with PVO caused by Gram-negative bacteria, Ki-Ho Park et al found that 8.5% of cases involved ESBL-producing bacteria (27). Furthermore, a French study reported that the prevalence of ESBL-producing bacteria was 6% in 77 cases of osteomyelitis caused by Gramnegative bacteria (18). In contrast, we found that nearly 40% of Enterobacteriaceae were resistant to fluoroquinolones, which is higher than recently reported (18,27).…”

Section: Discussioncontrasting

confidence: 73%

“…Furthermore, a French study reported that the prevalence of ESBL-producing bacteria was 6% in 77 cases of osteomyelitis caused by Gramnegative bacteria (18). In contrast, we found that nearly 40% of Enterobacteriaceae were resistant to fluoroquinolones, which is higher than recently reported (18,27). Like multidrug-resistant organisms (MDRO), CNS are also causing an increasing number of cases of PVO.…”

Section: Discussioncontrasting

confidence: 59%

“…In our center, if empirical therapy is required, we usually use ofloxacin combined with rifampin. Other combinations have been suggested, such as levofloxacin and rifampin (6,18), ciprofloxacin and clindamycin (8), or ciprofloxacin and amoxicillin-clavulanate (7), but the microbiological relevance of these combinations has never been assessed.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Susceptibility Pattern of Microorganisms Isolated by Percutaneous Needle Biopsy in Nonbacteremic Pyogenic Vertebral Osteomyelitis

Desoutter

Cottier

Ghout

et al. 2015

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 73%

Section: Discussioncontrasting

confidence: 59%

See 1 more Smart Citation

Susceptibility Pattern of Microorganisms Isolated by Percutaneous Needle Biopsy in Nonbacteremic Pyogenic Vertebral Osteomyelitis

Desoutter

Cottier

Ghout

et al. 2015

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…(OR 1,3), l'atteinte des tissus mous (OR 1,9) [2][3][4][5][6]. En France, la proportion de S. aureus résistant à la méticilline (SARM) dans les IOA est proche de 20 %, alors que les taux de résistance à la méticilline sont plus élevés pour les staphylocoques à coagulase négative (40 % à 50 %), impliqués le plus souvent dans les IOA chroniques et postopératoires tardives [3,4,7]. Les autres cocci à Gram positif classiquement impliqués dans les IOA sont les streptocoques bêta-hémolytiques, Streptococcus viridans, les entérocoques et les corynébactéries.…”

Section: éPidémiologie Des Ioa En France Et En Unités De Soins Intensunclassified

“…En cas de suspicion d'infection à SARM, il est proposé d'adjoindre de la vancomycine en administration intraveineuse continue (pour un taux sérique > 25 mg/L) ou de la fosfomycine. Les inconvé-nients de la fosfomycine sont le risque d'hypokaliémie majeure et d'un apport sodé élevé, les taux de résistance non négligeables des staphylocoques à coagulase négative à cet antibiotique, notamment S. capitis [7], et les difficultés récurrentes d'approvisionnement de cet antibiotique.…”

Section: Arthrite Aiguëunclassified

Prise en charge des infections ostéo-articulaires sévères en réanimation

et al. 2015

Self Cite

View full text Add to dashboard Cite

Les infections ostéo-articulaires (IOA) regroupent des situations cliniques variées, se distinguant par leur site (articulation, rachis, os longs…), leur évolution (aiguë, chronique), la présence ou non de matériel étranger (prothèse articulaire, matériel d'ostéosynthèse), le(s) micro-organisme(s) impliqué(s), le terrain et la voie de contamination (hémato-gène, postopératoire, de contiguïté…). Ces infections sont rares en soins intensifs et concernent des patients en sepsis sévère/choc septique induits par l'IOA ou nécessitant une surveillance en période postopératoire immédiate. La gravité du tableau clinique peut être liée au terrain, aux facteurs de virulence du pathogène et à l'existence d'un abcès ou d'une bactériémie associés à l'infection ostéo-articulaire. Si le diagnostic clinique est en général aisé, le diagnostic microbiologique est souvent difficile du fait de l'urgence à instaurer un traitement antibiotique. La ponction articulaire ou d'une collection para-articulaire est alors l'examen clé pour permettre une documentation microbiologique et sera associée à la réalisa-tion d'hémocultures. Dans ce contexte de soins intensifs, l'antibiothérapie probabiliste aura un large spectre et sera pré-cédée si possible d'une documentation microbiologique permettant d'adapter secondairement le traitement antibiotique. La complexité des paramètres impliqués dans les choix théra-peutiques nécessite une prise en charge multidisciplinaire.

show abstract

Measurement of ceftazidime concentration in human plasma by ultra‐performance liquid chromatography–tandem mass spectrometry. Application to critically ill patients and patients with osteoarticular infections

Rigo-Bonnin

Cobo-Sacristán

Padullés

et al. 2015

Biomedical Chromatography

View full text Add to dashboard Cite

Ceftazidime is an antibiotic belonging to the third generation of the cephalosporin family. It is indicated in the treatment of serious, simple or mixed bacterial infections, and its administration in continuous or intermittent infusion allows optimization of the concentration of antibiotic to keep it above the minimum inhibitory concentration. We developed and validated a chromatographic method by ultra-performance liquid chromatography-tandem mass spectrometry to measure ceftazidime concentration in human plasma. Following extraction with acetonitrile and 1,2-dichloroethane, the chromatographic separation was achieved using an Acquity ® UPLC ® BEH(TM) (2.1 × 100 mm i.d., 1.7 µm) reverse-phase C18 column, with a water-acetonitrile linear gradient containing 0.1% formic acid at a 0.4 mL/min flow rate. Ceftazidime and its internal standard (cefotaxime) were detected by electrospray ionization mass spectrometry in positive ion multiple reaction monitoring mode using mass-to-charge transitions of 547.0 → 467.9/396.1 and 456.0 → 395.8/324.1, respectively. The limit of quantification was 0.58 mg/L and linearity was observed in the range 0.58-160 mg/L. Coefficients of variation and absolute relative biases were <9.8 and 8.4%. The mean recovery for ceftazidime was 74.4 ± 8.1%. Evaluation of the matrix effect showed ion enhancement, and no carry-over was observed. The validated method could be applied to daily clinical laboratory practice to measure the concentration of ceftazidime in plasma.

show abstract

Bacterial epidemiology of osteoarticular infections in a referent center: 10-year study

Abstract: Level IV. Retrospective cohort study.

Cited by 58 publications

References 19 publications

Susceptibility Pattern of Microorganisms Isolated by Percutaneous Needle Biopsy in Nonbacteremic Pyogenic Vertebral Osteomyelitis

Susceptibility Pattern of Microorganisms Isolated by Percutaneous Needle Biopsy in Nonbacteremic Pyogenic Vertebral Osteomyelitis

Prise en charge des infections ostéo-articulaires sévères en réanimation

Measurement of ceftazidime concentration in human plasma by ultra‐performance liquid chromatography–tandem mass spectrometry. Application to critically ill patients and patients with osteoarticular infections

Contact Info

Product

Resources

About