Bacterial Colonization of Ureteral Double-J Stents in Patients with Negative Urine Culture

Ülker, Volkan; Yılmaz, Nisel; Ağuş, Neval; Can, Ertan; Çakmak, Özgür; Yücel, Cem; Çelik, Orçun; İlbey, Yusuf Özlem

doi:10.4274/jus.galenos.2019.2343

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…The most common microorganism before stenting in our study was E. coli , which is consistent with the data from other researchers who report that detection of E. coli colonizing stents is one of their most frequent findings [ 17 , 18 , 19 , 20 ].…”

Section: Discussionsupporting

confidence: 92%

Bacterial Colonization Incidence before and after Indwelling Double-J Ureteral Stents

et al. 2022

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The upper urinary tract stenting allows to restore the ureteral patency in various situations. However, one of the main disadvantages of stenting is bacterial contamination, which can be a source of persistent infections that hardly respond to antibiotic therapy. The aim of this study was to investigate the local spectrum of bacterial pathogens and their susceptibility to antibiotics in order to optimize antibacterial therapy after upper urinary tract stenting. A prospective observational study was conducted in which 140 urine samples were examined (70 before stenting and 70 after stenting). Bacterial growth was detected in 37 patients (52.8%) before stenting and in 43 patients (61.4%) after stenting. E. coli (13 (28.8%)) and Streptococcus spp. (8 (17.6%)) strains were more commonly detected before stenting; P. aeruginosa (15 (31.2%)) and E. coli (8 (16.6%)) were usually revealed after stenting. The proportion of P. aeruginosa strains after stenting grew from 4.4% up to 31.2%. E. coli strains were resistant to ampicillin (92.3% before and 100% after stenting). Three strains of E. coli (23.1%) and six strains of P. aeruginosa (40%) were multidrug-resistant. Determination of the bacterial sensitivity to antibiotics and identification of antibiotic-resistant forms of bacteria is a factor in reducing the risk of complications and optimizing antibiotic therapy during the upper urinary tract stenting.

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Section: Discussionsupporting

confidence: 92%

Bacterial Colonization Incidence before and after Indwelling Double-J Ureteral Stents

et al. 2022

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“…There are only a few studies on bacterial colonization on DJ stents in the literature; 10,11 however, none of them compare the different zones of the DJ stent. Yeniyol et al evaluate DJ stent by culture in 61 patients.…”

Section: Discussionmentioning

confidence: 99%

Bacterial colonization in three different parts of double J stent

Daroonkolaee

Yasseri

Khatami

et al. 2022

Journal of Clinical Urology

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Introduction: Due to the extensive use of indwelling stents and catheters in urology, bacterial colonization on these materials is a significant cause of infections in this group of patients. This study aims to investigate and compare the bacterial colonization in urine and in the three zones of the double J (DJ) stent. Methods: Between August 2019 and May 2020, 67 patients (18–78 years old) who underwent DJ stenting were recruited in the study. Surgeries before stenting included transurethral lithotripsy (TUL), percutaneous nephrolithotomy (PCNL), or diagnostic ureteroscopy. Before stenting, sterile urine samples were collected, and urinary cultures were performed, and the same procedure was done after removal of the DJ stents. DJ stent cultures were also performed. Results: 61 patients were analyzed. The mean age of all patients was 53 ± 16 years. The mean time of DJ installation in all patients was 27.6 ± 6.7 days (14–43 days). In these three parts of the DJ, 70.5%, 67.2%, and 72.1% of patients were without a colony, respectively. The microorganism distribution is approximately the same in the lower and upperparts, and Escherichia coli has the highest frequency (11.5%). The odds ratio (OR) of contamination was significantly lower in men than in women, but overweight and diabetes were not associated. Conclusion: The severity and pattern of bacterial colonization are not significantly different in the proximal, distal, and middle parts of the DJ stent.

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“…The positive correlation between indwelling time and microbial stent colonization has been extensively reported (60,91). In a clinical study analyzing 93 stents from 71 patients, Riedl et al (86) reported that all ureteral stents were colonized at 27 to 73 days from insertion, while 69% of stents were colonized at 1 to 48 days from insertion.…”

Section: Key Bacteria In Biofilms: the Significance Of Optimal Remova...mentioning

confidence: 85%

“…While one study (91) reported that bacterial colonization was present in all regions of patient-retrieved stents in 71% of cases, other reports have shown different results. For instance, Aydin et al (71) showed that the colonization rate was the same for each part of the stent in 30% of the cases.…”

Section: Distribution Patterns Of Biofilm and Encrustation In Uretera...mentioning

confidence: 90%

The interplay between bacterial biofilms, encrustation, and wall shear stress in ureteral stents: a review across scales

Amado,

Zheng,

Lange

et al. 2024

Front. Urol.

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Ureteral stents are hollow tubes that are inserted into the ureter to maintain the flow of urine from the kidney to the bladder. However, the use of these indwelling stents is associated with potential complications. Biofilm, an organized consortium of bacterial species embedded within a self-producing extracellular matrix, can attach to the outer and inner surfaces of ureteral stents. Furthermore, encrustation - defined as the buildup of mineral deposits on the stent surface - can occur independently or in parallel with biofilm formation. Both phenomena can cause stent obstruction, which can lead to obstructive pyelonephritis and make stent removal difficult. Understanding the influence of flow on the development of biofilm and encrustation and the impact of small mechanical environmental changes (e.g., wall shear stress distribution) is key to improve the long-term performance of stents. Identifying the optimal stent properties to prevent early bacterial attachment and/or crystal deposition and their growth, would represent a breakthrough in reducing biofilm-/encrustation-associated complications. This review identifies the most prevalent bacterial strains and crystal types associated with ureteral stents, and the process of their association with the stent surface, which often depends on patient comorbidities, stent material, and indwelling time. Furthermore, we focus on the often-overlooked role of fluid dynamics on biofilm and encrustation development in ureteral stents, across a range of physical scales (i.e., from micro- to macro-scale) with the aim of providing a knowledge base to inform the development of safer and more effective ureteral stents.

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Bacterial Colonization of Ureteral Double-J Stents in Patients with Negative Urine Culture

Cited by 6 publications

References 20 publications

Bacterial Colonization Incidence before and after Indwelling Double-J Ureteral Stents

Bacterial Colonization Incidence before and after Indwelling Double-J Ureteral Stents

Bacterial colonization in three different parts of double J stent

The interplay between bacterial biofilms, encrustation, and wall shear stress in ureteral stents: a review across scales

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