Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds

Khalid, Ayesha; Khan, Romana; Ul-Islam, Mazhar; Khan, Taous; Wahid, Fazli

doi:10.1016/j.carbpol.2017.01.061

Cited by 276 publications

(122 citation statements)

References 39 publications

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“…Reduction in wound area and photographic analysis of wound bed are most widely studied parameters for the assessment of wound healing. [ 59 ] The images of surgical wounds and wound healing on days 0 and 14 were shown in Figure . On day 0, the scaffolds were able to tightly connect to the wound edges.…”

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Liu

Zhang

et al. 2020

Macro Materials & Eng

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Skin injuries are an urgent health issue, which raises a great concern in the clinic. Although numerous strategies have been proposed to fabricate skin substitutes for treatment of wounds over the past several decades, fabricating an ideal skin substitute to replace the damaged one can still be a problem. In this study, a novel biomimetic 3D composite skin scaffold is fabricated by combining electrohydrodynamic (EHD) jetting, electrospinning, and coating techniques. Here, the first polycaprolactone (PCL) porous structure is produced by the EHD jetting. Next, the second polylactic acid (PLA) membrane consisted of nanoscale fibers is prepared on the PCL porous structure via the electrospinning. The PCL porous structure and PLA fibers membrane can mimic the dermis and epidermis layer, respectively. Furthermore, gelatin is used as coating solution to enhance the biocompatibility of the scaffold. The structure and morphology of the fabricated scaffolds are analyzed, and the mechanical properties are investigated as well. Moreover, the in vitro and in vivo experiments demonstrate the biocompatibility of the materials and the fabrication process. In conclusion, these results demonstrate that the composite scaffold is effective and holds great potential for skin regeneration in the clinic.

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Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Liu

Zhang

et al. 2020

Macro Materials & Eng

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“…In the area of nanocomposites, ZnO has been used as an antibacterial agent, UV absorber, and vulcanizing agent for elastomers . New studies propose using bacterial cellulose biopolymer in combination with ZnO to enhance the antibacterial properties and transform the nanocomposite into an excellent dressing material for burn wounds . A state‐of‐the‐art summary of the research study about ZnO is presented in Table .…”

Section: Nanofillersmentioning

confidence: 99%

“…[8] New studies propose using bacterial cellulose biopolymer in combination with ZnO to enhance the antibacterial properties and transform the nanocomposite into an excellent dressing material for burn wounds. [189] A state-of-the-art summary of the research study about ZnO is presented in Table 17. [192] Elastomer Polydimethylsiloxane CVT synthesis -Sensors for biomedical devices, optical displays [193] T A B L E 1 6 Magnesium oxide combinations with polymer matrixes: processing methods, modification, properties, and applications Used in wastewater treatment [202] Starch, amino acid (lysine), polypropylene glycol…”

Section: Zinc Oxidementioning

confidence: 99%

An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

2019

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Polymeric nanocomposites are the materials incorporating nanosized inclusions into the polymer matrixes. The result of the addition of nanoparticles/fibers is a drastic improvement in properties that may include mechanical, electrical, thermal conductivity, or even the acoustical properties. Polymer nanocomposites have spawned huge interest for the development of high‐performance products such as lightweight sensors, thin‐film capacitors, batteries, flame retardant products, biodegradable and biocompatible materials, and so on. The field of polymer nanocomposites has been at the forefront of research in the polymer community for the past few decades and an extremely large number of scientific papers have been published. Nevertheless, application‐oriented guidelines for selecting the ecofriendly nanocomposites for advanced industrial applications are missing in the state of the art. This review article summarizes the current state‐of‐the‐art polymeric nanocomposites, highlighting prominent nanofillers categorized based on their applications, origins, dimensional characteristics, and so on. Each filler type contains a short description of its main feature together with the most relevant and potential applications. To address the global concern about nondegradable wastes, novel green alternatives of each nanofiller type are discussed. Special attention is also given to the biocompatibility properties of the composites. This study provides a state‐of‐the‐art road map to select multifunctional polymeric nanocomposites from huge varieties for advanced industrial applications.

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“…34 The BC-TiO 2 composites and BC lms were cut into 20 mm discs. Silver sulfadiazine cream was also coated on 20 mm discs of the sterilized lter paper and used as a positive control.…”

Section: Antimicrobial Assay Of Bc-tio 2 Composite Lmsmentioning

confidence: 99%

Bacterial cellulose–TiO₂nanocomposites promote healing and tissue regeneration in burn mice model

et al. 2017

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The development of novel cutaneous wound treatments particularly for burns is of paramount importance due to complex pathophysiology, prevalent infection and clinical complexities associated with burn care.The main focus of the current study was to investigate the in vivo burn wound healing potential of bacterial cellulose (BC) and titanium dioxide (TiO 2 ) nanocomposites (BC-TiO 2 ). The physicochemical characterization of BC-TiO 2 was carried out using FE-SEM, XRD and FT-IR. The antimicrobial activity of the nanocomposite was tested against Escherichia coli and Staphylococcus aureus through agar disc diffusion protocol. The in vivo wound healing efficacy was evaluated in burn wound model through wound area measurement, percent contraction and histopathology. The characterization results confirmed the successful incorporation of TiO 2 nanoparticles into BC. The nanocomposites exhibited 81 AE 0.4% and 83 AE 0% inhibition against E. coli and S. aureus, respectively. The composite bandage showed good healing pattern with 71 AE 2.41% wound contraction. Histopathological evidence like the formation of healthy granulation tissue and the re-epithelization indicated the healing progression in the composite treated group. In comparison, the BC treated group has partial epithelization and signs of inflammation. These results proved that the composite dressing possesses an excellent healing potential with faster re-epithelization rate and accelerated wound contraction ability and thus could be a candidate for the development of cutaneous wound care products to address the limitations of the conventional wound dressing for burns.

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Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds

Cited by 276 publications

References 39 publications

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

Bacterial cellulose–TiO₂nanocomposites promote healing and tissue regeneration in burn mice model

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Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds

Cited by 276 publications

References 39 publications

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

Bacterial cellulose–TiO2nanocomposites promote healing and tissue regeneration in burn mice model

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Bacterial cellulose–TiO₂nanocomposites promote healing and tissue regeneration in burn mice model