Bacterial cellulose-based hydrogel for wound healing: characterization and in vitro evaluation

Abstract

Bacterial cellulose (BC) has been considered a promising biopolymer with applications in several areas of knowledge, including medicine, mainly due to its ability to assist in the treatment of dermal lesions. Many groups and companies have been making efforts to develop new BC-based materials in order to add new characteristics and therapeutic possibilities. Recently, Seven Indústria de Produtos Biotecnológicos Ltda company developed a BC-based hydrogel aiming to verify the interaction among the formulation components, its potential for wound healing and biocompatibility studies. BC-based hydrogel was characterized and compared with pristine BC film. Physicochemical characterization includes rheological measurements, thermal analyses, field emission gun - scanning electron microscopy (FE-SEM) and in vitro cell migration. BC-based hydrogel showed adequate interaction among the components of the formulation, which may positively influence its stability. In addition, the BC-based hydrogel accelerated the healing processes demonstrating its potential in dermal lesion treatment.

Antimicrobial Formulation of a Bacterial Nanocellulose/Propolis-Containing Photosensitizer for Biomedical Applications

“…Rheological flow properties are related to the deformation of the material when it is subjected to shear stress, providing information about its behavior and stability, which is fundamental for quality control, material acceptance, and effectiveness [ 65 , 66 ]. All formulations showed non-Newtonian behavior, since there was no linear proportional ratio between shear stress and shear rate.…”

“…Figure 1 D shows the flow curve of a representative sample of a BNC-based hydrogel. In terms of rheological behavior, the flow curve shows the pseudoplastic behavior that results from the alignment of the disrupted three-dimensional network in the system in the direction of flow, providing the protective film formation characteristic that allows the skin surface to be covered, promoting improved protection [ 66 ].…”

“…This is an important characteristic for topical application formulations due to the ease of removing the contents of the package and allowing the product to be spread on the skin, preventing runoff [ 68 , 69 ]. Materials with thixotropic characteristics also tend to have increased shelf life, as they maintain constant viscosity during storage, avoiding the separation of constituents from the formulations [ 66 ].…”

Effect of crosslinker and nanostructure on adsorption and release of paraquat herbicide from different natural hydrogel nanocomposites

“…These classes of materials are characterized by absorbing a high amount of water into the interior by having three-dimensional networks, and which are formed by the crosslinking process. [10][11][12] They can be prepared from a combination of various synthetic or natural materials and polymers, such as sodium alginate and starch. Sodium alginate (SA) is a polysaccharide with a high capacity to form hydrogels when immersed in a solution containing di or trivalent ions.…”