Potential applications of bacterial cellulose and its composites for cancer treatment

Islam, Salman Ul; Ul‐Islam, Mazhar; Ahsan, Haseeb; Ahmed, Muhammad Bilal; Shehzad, Adeeb; Fatima, Atiya; Sonn, Jong Kyung; Lee, Young-Sup

doi:10.1016/j.ijbiomac.2020.12.042

Cited by 51 publications

(30 citation statements)

References 120 publications

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“…However, for this study, these values were significantly higher after BC rehydration [26]. According to Ul-Islam et al, BC containing Aloe vera gel possessed 3-fold better mechanical strength than pure BC [11]. Likewise, the incorporation of the Scrophularia striata extracts caused significantly lower tensile strength and Young's modulus compared to the control film (pure BC).…”

Section: Discussioncontrasting

confidence: 54%

“…Bacterial cellulose membrane (BC) is characterized by high purity (lack of lignin, hemicellulose, and pectin), high degree of polymerization, high porosity, beneficial mechanical properties, high crystallinity, good moldability, biocompatibility, good permeability, resistance to degradation, high water absorption capacity (more than 90% of its weight) and are environmentally friendly [3][4][5][6][7][8]. These properties, together with tensile strength, make these membranes applicable as a skin repair material [9] and in wound dressing [10,11]. The BC is well tolerated by the skin and does not irritate [3].…”

Section: Introductionmentioning

confidence: 99%

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Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin

Nowak

Ossowicz‐Rupniewska

Rakoczy

et al. 2021

IJMS

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Bacterial cellulose membranes (BCs) are becoming useful as a drug delivery system to the skin. However, there are very few reports on their application of plant substances to the skin. Komagataeibacter xylinus was used for the production of bacterial cellulose (BC). The BC containing 5% and 10% ethanolic extract of Epilobium angustifolium (FEE) (BC-5%FEE and BC-10%FEE, respectively) were prepared. Their mechanical, structural, and antioxidant properties, as well as phenolic acid content, were evaluated. The bioavailability of BC-FESs using mouse L929 fibroblasts as model cells was tested. Moreover, In Vitro penetration through the pigskin of the selected phenolic acids contained in FEE and their accumulation in the skin after topical application of BC-FEEs was examined. The BC-FEEs were characterized by antioxidant activity. The BC-5% FEE showed relatively low toxicity to healthy mouse fibroblasts. Gallic acid (GA), chlorogenic acid (ChA), 3,4-dihydroxybenzoic acid (3,4-DHB), 4-hydroxybenzoic acid (4-HB), 3-hydroxybenzoic acid (3-HB), and caffeic acid (CA) found in FEE were also identified in the membranes. After topical application of the membranes to the pigskin penetration of some phenolic acid and other antioxidants through the skin as well as their accumulation in the skin was observed. The bacterial cellulose membrane loaded by plant extract may be an interesting solution for topical antioxidant delivery to the skin.

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin

Nowak

Ossowicz‐Rupniewska

Rakoczy

et al. 2021

IJMS

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“…This polysaccharide, and particularly its nanoscale forms, viz. cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs) and bacterial nanocellulose (BNC) [6], are showing incredible potential as precursors of nanomaterials for a deluge of applications, including in the fight against cancer [7][8][9]. In fact, the number of developed systems for cancer diagnosis and treatment [7,9,10] is increasing at a fast pace since this large group of diseases is the second leading cause of death globally, with ca.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanocrystals/Chitosan-Based Nanosystems: Synthesis, Characterization, and Cellular Uptake on Breast Cancer Cells

et al. 2021

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Cellulose nanocrystals (CNCs) are elongated biobased nanostructures with unique characteristics that can be explored as nanosystems in cancer treatment. Herein, the synthesis, characterization, and cellular uptake on folate receptor (FR)-positive breast cancer cells of nanosystems based on CNCs and a chitosan (CS) derivative are investigated. The physical adsorption of the CS derivative, containing a targeting ligand (folic acid, FA) and an imaging agent (fluorescein isothiocyanate, FITC), on the surface of the CNCs was studied as an eco-friendly methodology to functionalize CNCs. The fluorescent CNCs/FA-CS-FITC nanosystems with a rod-like morphology showed good stability in simulated physiological and non-physiological conditions and non-cytotoxicity towards MDA-MB-231 breast cancer cells. These functionalized CNCs presented a concentration-dependent cellular internalization with a 5-fold increase in the fluorescence intensity for the nanosystem with the higher FA content. Furthermore, the exometabolic profile of the MDA-MB-231 cells exposed to the CNCs/FA-CS-FITC nanosystems disclosed a moderate impact on the cells’ metabolic activity, limited to decreased choline uptake and increased acetate release, which implies an anti-proliferative effect. The overall results demonstrate that the CNCs/FA-CS-FITC nanosystems, prepared by an eco-friendly approach, have a high affinity towards FR-positive cancer cells and thus might be applied as nanocarriers with imaging properties for active targeted therapy.

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“…The BC is produced in the form of highly swollen membranes with high water content (>90%) [2]. The BC has good physical and mechanical properties, high purity, and biocompatibility, which engendered considerable interest in this material in the biomedical field [2,5,6], among others specifically as wound healing membranes [5,7] scaffolds for tissue engineering [8,9], artificial blood vessels [3,5].…”

Section: Introductionmentioning

confidence: 99%

Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose

Ossowicz‐Rupniewska

Rakoczy

Nowak

et al. 2021

IJMS

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The potential of bacterial cellulose as a carrier for the transport of ibuprofen (a typical example of non-steroidal anti-inflammatory drugs) through the skin was investigated. Ibuprofen and its amino acid ester salts-loaded BC membranes were prepared through a simple methodology and characterized in terms of structure and morphology. Two salts of amino acid isopropyl esters were used in the research, namely L-valine isopropyl ester ibuprofenate ([ValOiPr][IBU]) and L-leucine isopropyl ester ibuprofenate ([LeuOiPr][IBU]). [LeuOiPr][IBU] is a new compound; therefore, it has been fully characterized and its identity confirmed. For all membranes obtained the surface morphology, tensile mechanical properties, active compound dissolution assays, and permeation and skin accumulation studies of API (active pharmaceutical ingredient) were determined. The obtained membranes were very homogeneous. In vitro diffusion studies with Franz cells were conducted using pig epidermal membranes, and showed that the incorporation of ibuprofen in BC membranes provided lower permeation rates to those obtained with amino acids ester salts of ibuprofen. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes indicates the enormous potentialities of using BC membranes for transdermal application of ibuprofen in the form of amino acid ester salts.

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Potential applications of bacterial cellulose and its composites for cancer treatment

Cited by 51 publications

References 120 publications

Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin

Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin

Cellulose Nanocrystals/Chitosan-Based Nanosystems: Synthesis, Characterization, and Cellular Uptake on Breast Cancer Cells

Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose

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