Bacterial cellulose and bacterial cellulose-vaccarin membranes for wound healing

Qiu, Yinsheng; Qiu, Ling; Cui, Jing; Wei, Qufu

doi:10.1016/j.msec.2015.10.016

Cited by 181 publications

(96 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(Wiegand et al, 2006) focused on the formation of a composite of BC with collagen type I that is able to reduce the proteases amount, interleukin concentration and the ROS activity, while Moreno de Freitas et al (Barud et al, 2013) demonstrated the considerable antimicrobial activity and wound healing capability of a BC membrane containing an ethanol soluble propolis extract. In a different study, it was also demonstrated that BC including vaccarin increases wound healing by improvement of cell adhesion (Qiu, Qiu, Cui, & Wei, 2016). …”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

Morais

Silva

Sintra

et al. 2019

Carbohydrate Polymers

View full text Add to dashboard Cite

The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

Morais

Silva

Sintra

et al. 2019

Carbohydrate Polymers

View full text Add to dashboard Cite

show abstract

“…11 In another study, the composite of BC with vaccarin demonstrated an excellent healing potential and biocompatibility in rat skin model. 12 Despite these encouraging pre-clinical results, the search for an ideal skin repair material still continues.…”

Section: Introductionmentioning

confidence: 99%

Bacterial cellulose–TiO₂nanocomposites promote healing and tissue regeneration in burn mice model

et al. 2017

View full text Add to dashboard Cite

The development of novel cutaneous wound treatments particularly for burns is of paramount importance due to complex pathophysiology, prevalent infection and clinical complexities associated with burn care.The main focus of the current study was to investigate the in vivo burn wound healing potential of bacterial cellulose (BC) and titanium dioxide (TiO 2 ) nanocomposites (BC-TiO 2 ). The physicochemical characterization of BC-TiO 2 was carried out using FE-SEM, XRD and FT-IR. The antimicrobial activity of the nanocomposite was tested against Escherichia coli and Staphylococcus aureus through agar disc diffusion protocol. The in vivo wound healing efficacy was evaluated in burn wound model through wound area measurement, percent contraction and histopathology. The characterization results confirmed the successful incorporation of TiO 2 nanoparticles into BC. The nanocomposites exhibited 81 AE 0.4% and 83 AE 0% inhibition against E. coli and S. aureus, respectively. The composite bandage showed good healing pattern with 71 AE 2.41% wound contraction. Histopathological evidence like the formation of healthy granulation tissue and the re-epithelization indicated the healing progression in the composite treated group. In comparison, the BC treated group has partial epithelization and signs of inflammation. These results proved that the composite dressing possesses an excellent healing potential with faster re-epithelization rate and accelerated wound contraction ability and thus could be a candidate for the development of cutaneous wound care products to address the limitations of the conventional wound dressing for burns.

show abstract

“…Vaccarin is able to protect the vascular endothelial cells from injury triggered by high glucose [18]. Reconstruction of bacterial cellulose-vaccarin promotes wound healing in mice [19]. Hypaphorine from different marine sources is shown to possess anti-inflammatory properties [20].…”

Section: Introductionmentioning

confidence: 99%

Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells

Sun¹,

Zhu²,

Lin³

et al. 2017

Cell Physiol Biochem

Self Cite

View full text Add to dashboard Cite

Background /Aims: Accumulating evidence indicates that endothelial inflammation is one of the critical determinants in pathogenesis of atherosclerotic cardiovascular disease. Our previous studies had demonstrated that Vaccariae prevented high glucose or oxidative stress-triggered endothelial dysfunction in vitro. Very little is known about the potential effects of hypaphorine from Vaccariae seed on inflammatory response in endothelial cells. Methods: In the present study, we evaluated the anti-inflammatory effects of Vaccariae hypaphorine (VH) on lipopolysaccharide (LPS)-challenged endothelial EA.hy926 cells. The inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), monocyte chemoattractant protein 1 (MCP-1) and vascular cellular adhesion molecule-1 (VCAM-1) were measured by real-time PCR (RT-PCR). The expressions of adenosine monophosphate-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), toll-like receptor 4 (TLR4), peroxisome proliferator-activated receptor γ (PPARγ) were detected by Western blotting or immunofluorescence. Results: We showed that LPS stimulated the expressions of TNF-α, IL-1β, MCP-1, VCAM-1 and TLR4, but attenuated the phosphorylation of AMPK and ACC as well as PPARγ protein levels, which were reversed by VH pretreatment. Moreover, we observed that LPS-upregulated TLR4 protein expressions were inhibited by PPARγ agonist pioglitazone, and the downregulated PPARγ expressions in response to LPS were partially restored by knockdown of TLR4. The negative regulation loop between TLR4 and PPARγ response to LPS was modulated by AMPK agonist AICAR (5-Aminoimidazole-4-carboxamide riboside or acadesine) or A769662. Conclusions: Taken together, our results suggested that VH ameliorated LPS-induced inflammatory cytokines production in endothelial cells via inhibition of TLR4 and activation of PPARγ, dependent on AMPK signalling pathway.

show abstract

Bacterial cellulose and bacterial cellulose-vaccarin membranes for wound healing

Cited by 181 publications

References 21 publications

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

Bacterial cellulose–TiO₂nanocomposites promote healing and tissue regeneration in burn mice model

Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells

Contact Info

Product

Resources

About

Bacterial cellulose and bacterial cellulose-vaccarin membranes for wound healing

Cited by 181 publications

References 21 publications

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

Bacterial cellulose–TiO2nanocomposites promote healing and tissue regeneration in burn mice model

Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells

Contact Info

Product

Resources

About

Bacterial cellulose–TiO₂nanocomposites promote healing and tissue regeneration in burn mice model