Bacterial biofilms as platforms engineered for diverse applications

Zhong, Li; Wang, Xinyu; Wang, Jie; Yuan, Xinyi; Jiang, Xiaoyu; Wang, Yanyi; Zhong, Chao; Xu, Dake; Gu, Tingyue; Wang, Fuhui

doi:10.1016/j.biotechadv.2022.107932

Cited by 32 publications

(23 citation statements)

References 138 publications

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“…After aggregating into clusters via adhesins and cytoderm proteins, the bacteria change from a planktonic state to a bacterial thin film. A biofilm refers to an aggregated mixture of bacteria, biofilm matrix, and extracellular polymers. , Biofilm production is the most important process in IBD formation because it can hinder the infiltration of antimicrobials and immune cells, helping pathogenic bacteria escape attacks from antibiotics and the host immune system. Biofilms also cause the development of drug-resistant bacteria.…”

Section: Discussionmentioning

confidence: 99%

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Yao

et al. 2022

ACS Biomater. Sci. Eng.

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Infected bone defects (IBDs) cause significant economic and psychological burdens, posing a huge challenge to clinical orthopedic surgeons. Traditional approaches for managing IBDs possess inevitable shortcomings; therefore, it is necessary to develop new functionalized scaffolds. Tantalum (Ta) has been widely used in load-bearing orthopedic implants due to its good biocompatibility and corrosion resistance. However, undecorated Ta could only structurally repair common bone defects, which failed to meet the clinical needs of bacteriostasis for IBDs. Researchers have made great efforts to functionalize Ta scaffolds to enhance their antibacterial activity through various methods, including surface coating, alloying, and micro-and nanostructure modifications. Additionally, several studies have successfully utilized Ta to modify orthopedic scaffolds for enhanced antibacterial function. These studies remarkably extended the application range of Ta. Therefore, this review systematically outlines the advances in the fundamental and clinical application of Ta in the treatment of IBDs, focusing on the antibacterial properties of Ta, its functionalization for bacteriostasis, and its applications in the modification of orthopedic scaffolds. This study provides researchers with an overview of the application of Ta in the treatment of IBDs.

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Section: Discussionmentioning

confidence: 99%

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Yao

et al. 2022

ACS Biomater. Sci. Eng.

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“…Indeed, humans have long used materials made of living cells, such as activated sludge for wastewater purification , and probiotics encapsulated in polymeric matrices for gastrointestinal disease treatment . However, the functional properties of these materials mainly depend on the natural features of living cells (e.g., decomposition of organic pollutants or secretion of therapeutic molecules), and it is challenging to reprogram the dynamic biological functions of these materials.…”

Section: Living Cells Are Masters Of Making and Using Materialsmentioning

confidence: 99%

Engineered Living Materials For Sustainability

Wang

Huang

et al. 2022

Chem. Rev.

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Recent advances in synthetic biology and materials science have given rise to a new form of materials, namely engineered living materials (ELMs), which are composed of living matter or cell communities embedded in self-regenerating matrices of their own or artificial scaffolds. Like natural materials such as bone, wood, and skin, ELMs, which possess the functional capabilities of living organisms, can grow, self-organize, and self-repair when needed. They also spontaneously perform programmed biological functions upon sensing external cues. Currently, ELMs show promise for green energy production, bioremediation, disease treatment, and fabricating advanced smart materials. This review first introduces the dynamic features of natural living systems and their potential for developing novel materials. We then summarize the recent research progress on living materials and emerging design strategies from both synthetic biology and materials science perspectives. Finally, we discuss the positive impacts of living materials on promoting sustainability and key future research directions.

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“…Researchers have always envisaged the use of biofilm characteristics to create dynamic, environmentally sensitive, and adjustable active functional materials. Practical applications of biofilms require sophisticated and defined geometries to adapt to their areas of application, [ 47 ] however, the growth of biofilms lacks spatial control and cannot meet various applications. With the stability and versatility of 3D bioprinting technology, the spatial heterogeneity and mechanical stability of natural biofilms can be better simulated, biofilm active functional materials can show clear spatial patterns, have higher resolution and attractive functions, and the manufacturing of biofilm active functional materials has been further developed.…”

Section: For Construction Of Artificial Biofilm or Direct Production ...mentioning

confidence: 99%

The Next Frontier of 3D Bioprinting: Bioactive Materials Functionalized by Bacteria

Liu

Xia

Liu

et al. 2022

Small

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VCH. B) Fabrication of eggshell membrane-inspired bioresponsive devices using 3D printing Reproduced with permission. [69] Copyright 2020, American Chemical Society C) Digital design and fabrication of 3D multi-material structures with programmable biohybrid surfaces. Reproduced with permission. [70] Copyright 2019, Wiley-VCH. D) 4D printing ELMs capable of multiple shape change and drug delivery devices. Reproduced with permission. [60] Copyright 2021, Wiley-VCH .

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Bacterial biofilms as platforms engineered for diverse applications

Cited by 32 publications

References 138 publications

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Current Advances and Applications of Tantalum Element in Infected Bone Defects

Engineered Living Materials For Sustainability

The Next Frontier of 3D Bioprinting: Bioactive Materials Functionalized by Bacteria

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