Bacterial-Based Methods for Cancer Treatment: What We Know and Where We Are

Rommasi, Foad

doi:10.1007/s40487-021-00177-x

Cited by 29 publications

(13 citation statements)

References 156 publications

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“…The potential of bacteria and their metabolites to destroy tumor cells as a novel anti-neoplastic technique has been investigated by scientists and researchers throughout the last ten years [ 14 , 99 ]. They have discovered that on average, healthy cells, bacteria, and their products are not only less harmful but also have fewer adverse consequences [ 100 , 101 ].…”

Section: Introductionmentioning

confidence: 99%

“…In anti-cancer bacteria-based immunotherapy techniques, the utilized bacteria may exist in a state of being alive or weakened and potentially even manifest as genetically modified variants [ 99 , 175 ]. A cancer therapy mediated by a safe bacterium should possess characteristics like cytotoxicity towards cancer cells or immunogenicity, thereby minimizing harm to healthy cells, exhibiting a preference for cancer cells, and maintaining stability within the physiological conditions of the human body [ 176 , 177 ].…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future

Yarahmadi,

Zare,

Aghayari

et al. 2024

Cell Commun Signal

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Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of approximately seven million people annually, establishing itself as one of the most significant health challenges globally. The discovery and identification of new anti-cancer drugs that kill or inactivate cancer cells without harming normal and healthy cells and reduce adverse effects on the immune system is a potential challenge in medicine and a fundamental goal in Many studies. Therapeutic bacteria and viruses have become a dual-faceted instrument in cancer therapy. They provide a promising avenue for cancer treatment, but at the same time, they also create significant obstacles and complications that contribute to cancer growth and development. This review article explores the role of bacteria and viruses in cancer treatment, examining their potential benefits and drawbacks. By amalgamating established knowledge and perspectives, this review offers an in-depth examination of the present research landscape within this domain and identifies avenues for future investigation. Graphical Abstract The double-edged sword role of bacteria and viruses in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future

Yarahmadi,

Zare,

Aghayari

et al. 2024

Cell Commun Signal

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show abstract

“…In addition, bacteria can be genetically engineered for their accessible genes, and used as vectors to deliver anti-tumor agents or immunomodulatory proteins to tumor sites ( 11 , 12 ). Importantly, the genetically modified, live attenuated bacteria can be eliminated by antibiotics or triggering and strengthening host immune responses by immunomodulators such as cytokines and host defense peptides after the cancer treatment to prevent unintended infections ( 13 – 15 ).…”

Section: Introductionmentioning

confidence: 99%

Pseudomonas aeruginosa in Cancer Therapy: Current Knowledge, Challenges and Future Perspectives

2022

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Drug resistance, undesirable toxicity and lack of selectivity are the major challenges of conventional cancer therapies, which cause poor clinical outcomes and high mortality in many cancer patients. Development of alternative cancer therapeutics are highly required for the patients who are resistant to the conventional cancer therapies, including radiotherapy and chemotherapy. The success of a new cancer therapy depends on its high specificity to cancer cells and low toxicity to normal cells. Utilization of bacteria has emerged as a promising strategy for cancer treatment. Attenuated or genetically modified bacteria were used to inhibit tumor growth, modulate host immunity, or deliver anti-tumor agents. The bacteria-derived immunotoxins were capable of destructing tumors with high specificity. These bacteria-based strategies for cancer treatment have shown potent anti-tumor effects both in vivo and in vitro, and some of them have proceeded to clinical trials. Pseudomonas aeruginosa, a Gram-negative bacterial pathogen, is one of the common bacteria used in development of bacteria-based cancer therapy, particularly known for the Pseudomonas exotoxin A-based immunotoxins, which have shown remarkable anti-tumor efficacy and specificity. This review concisely summarizes the current knowledge regarding the utilization of P. aeruginosa in cancer treatment, and discusses the challenges and future perspectives of the P. aeruginosa-based therapeutic strategies.

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“…Standard cancer treatments such as surgery, radiotherapy, and chemotherapy have been efficient in treating and alleviating most symptoms; however, they remain ineffective for nearly half of the cancer cases [ 2 ]. There is a dire need for alternative potent therapeutic methods to evade the disease entirely [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Microbiota and Extracellular Vesicles in Anti-PD-1/PD-L1 Therapy

Mishra

Amatya

Salmi

et al. 2022

Cancers

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Cancer is a deadly disease worldwide. In light of the requisite of convincing therapeutic methods for cancer, immune checkpoint inhibition methods such as anti-PD-1/PD-L1 therapy appear promising. Human microbiota have been exhibited to regulate susceptibility to cancer as well as the response to anti-PD-1/PD-L1 therapy. However, the probable contribution of bacterial extracellular vesicles (bEVs) in cancer pathophysiology and treatment has not been investigated much. bEVs illustrate the ability to cross physiological barriers, assemble around the tumor cells, and likely modify the tumor microenvironment (EVs). This systematic review emphasizes the correlation between cancer-associated extracellular vesicles, particularly bEVs and the efficacy of anti-PD-1/PD-L1 therapy. The clinical and pharmacological prospective of bEVs in revamping the contemporary treatments for cancer has been further discussed.

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Bacterial-Based Methods for Cancer Treatment: What We Know and Where We Are

Cited by 29 publications

References 156 publications

Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future

Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future

Pseudomonas aeruginosa in Cancer Therapy: Current Knowledge, Challenges and Future Perspectives

Microbiota and Extracellular Vesicles in Anti-PD-1/PD-L1 Therapy

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