Bacterial Antigens and Aggregated Gamma Globulin in the Lesions of Nodular Vasculitis

Parish, W. E.; Rhodes, E.L.

doi:10.1111/j.1365-2133.1967.tb15822.x

Cited by 82 publications

(35 citation statements)

References 21 publications

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“…Vasculitis secondary to TB was first described in 1967 by Parish and Rhodes (5) . Tuberculosis is known to mimic large vessel vasculitis resembling Takayasu Arteritis but this commonly involves the aorta and its branches.…”

Section: Discussionmentioning

confidence: 99%

Digital Gangrene in Disseminated Tuberculosis: A Rare Presentation

Bansal¹,

Tyagi²

2017

IOSR JDMS

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Section: Discussionmentioning

confidence: 99%

Digital Gangrene in Disseminated Tuberculosis: A Rare Presentation

Bansal¹,

Tyagi²

2017

IOSR JDMS

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“…Infections may cause vasculitis by direct invasion of the wall of vessels of any size or by immune mechanisms, including immune complex disease and cryoglobulinemia [54,55,56]. Leucocytoclastic vasculitis may be caused by a range of viral, fungal, bacterial and parasitic diseases.…”

Section: Glands (Eg) (A) (Hematoxylin and Eosin) Dilated Lymphatic (mentioning

confidence: 99%

“…While M.Tb and HIV may cause vascular pathology independently by several mechanisms, the presence of vasculitis in the context of TB and HIV co-infection is poorly reported [54][55][56][57][58][59][60][61][62]. The co-occurrence of TB and vasculitis was first reported in 1967 [55]. Circulating immune complexes, the levels of which are related to disease activity, have been demonstrated in pulmonary TB [55].…”

Section: Glands (Eg) (A) (Hematoxylin and Eosin) Dilated Lymphatic (mentioning

confidence: 99%

Vulval Tuberculosis: The Histomorphological Spectrum in Patients with HIV Co-Infection and AIDS

Gb¹,

Ramdial²,

Nargan³

et al. 2017

J AIDS Clin Res

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Objective: Vulval tuberculosis (TB) is reported rarely. The histomorphological spectrum and diagnostic mimicry thereof in patients with concomitant HIV infection/ AIDS is unreported to date. This study aimed to appraise the histopathologic spectrum of vulval TB in HIV co-infected patients and to identify histopathological diagnostic challenges, mimicry and pitfalls.Methods: Ten year retrospective study that reappraised the histomorphological features of vulval TB in HIV-infected patients. Results:The clinical descriptions of the biopsied lesions from 19 patients that form the study cohort encompassed nodules (9), ulcers (5), hypertrophy/edema (3) and abscesses (2). The main microscopic features included necrotizing and non-necrotizing granulomatous inflammation, ulceration with a zoned inflammatory response and chronic suppurative inflammation. The necrotizing component had the typical morphology of caseative necrosis or of suppuration/karyorrhexis or an admixture of both necrosis types. Vasculitis, of varied histomorphology, was present in 15 biopsies. Infective special stains were pivotal diagnostic tools. The presence of mycobacteria on Ziehl Neelsen stains (ZNs) and absence of nonmycobacterial infective agents on additional infective stains, underpinned TB diagnosis, especially in biopsies that lacked prototypical granulomatous inflammation or of infective mimickers that manifest with a granulomatous phenotype. ZNs also confirmed mycobacteria in vasculitic foci. The absence of mycobacteria on ZNs facilitated the diagnosis of tuberculids. Conclusion:Lesions with a common clinical appearance had heterogeneous histomorphological features, while lesions with common histopathological features demonstrated divergent clinical morphology. Infective, especially Ziehl Neelsen, stains are pivotal in the histopathological work-up of infective/inflammatory vulval biopsies. It is possible that the rarely reported anergic mononuclear or abscessing features, pseudotumoral spindle cell reactions, ulcers with a zoned inflammatory response and the presence of vasculitis of varied type, are clues to the HIV-TB tissue partnership. Increased clinicopathological investigation of and reporting on vulval TB in the HIV/AIDS afflicted population is pivotal to ascertain this.

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“…In fact, cutaneous leucocytoclastic vasculitis is a rare complication of ATT 3 . Coronary vasculitis secondary to ATT is even rarer and to the best of our knowledge, no such case has yet been reported.…”

Section: Case Reportmentioning

confidence: 99%

“…It can be primary or secondary to other systemic diseases 2 . The combination of tuberculosis and vasculitis was first described by Parish and Rhodes in 1967 3 . There are two general types of pulmonary tuberculosis-related vasculitis: leucocytoclastic vasculitis (a manifestation of pulmonary tuberculosis) and antitubercular medication-associated vasculitis (particularly with rifampicin therapy) 4 .…”

Section: Introductionmentioning

confidence: 99%