Bacteria in the pathogenesis of inflammatory bowel disease

Flanagan, Paul; Campbell, Barry J.; Rhodes, Jonathan M.

doi:10.1042/bst0391067

Cited by 40 publications

(32 citation statements)

References 66 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, genetic, phenotyping, and microbial diversity within UC patients indicate that this disease is the heterogeneous cohort of different disorders, which probably has predictable natural histories (23). However, recent studies demonstrated that Entrobacteriaceae, E. coli, and Mycobacterium paratuberculosis strains are associated with IBD (24). The current study showed that there was a higher rate of fimH gene in UC patients than control subjects; a difference that was statistically significant.…”

Section: Discussioncontrasting

confidence: 44%

Prevalence of Adherent-Invasive Escherichia coli with fimH Gene Isolated from Iranian Patients with Ulcerative Colitis

Asiabar

Aghdaei

Sabokbar

et al. 2017

Jundishapur J Microbiol

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 44%

Prevalence of Adherent-Invasive Escherichia coli with fimH Gene Isolated from Iranian Patients with Ulcerative Colitis

Asiabar

Aghdaei

Sabokbar

et al. 2017

Jundishapur J Microbiol

View full text Add to dashboard Cite

“…Mycobacterium avium spp. paratuberculosis or adherent-invasive Escherichia coli (AIEC)) have been proposed as causative agents, mainly in CD [138][139][140]. Moreover, various clinical studies were conducted to analyze the potential therapeutic effect of different antibacterial regimens (usually with the agents clarithromycin, metronidazole, ciprofloxacin or rifaximin) (see section 3.4.…”

Section: The Microbiotamentioning

confidence: 99%

Gut Inflammation: Current Update on Pathophysiology, Molecular Mechanism and Pharmacological Treatment Modalities

Gyires¹,

Tóth²,

Zádori

2014

CPD

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory condition of the gastrointestinal tract. The two main forms of IBD are Crohn's disease and ulcerative colitis. According to the recent concept the disease is caused by a combination of factors, including genetics, immune dysregulation, barrier dysfunction and the change in microbial flora. Environmental factors, such as changes in diet, antibiotic use, smoking or improved domestic hygiene (e.g. eradication of intestinal helminths) probably contribute to the development and increased prevalence of IBD. Dysregulation of mucosal immunity in IBD causes an overproduction of inflammatory cytokines which resulted in uncontrolled intestinal inflammation. Based on extensive research over the last decade, besides the conventional therapy, there are several novel pathways and specific targets, on which focus new therapeutics. New therapeutics aim 1./ to correct genetic susceptibility by stimulating NOD2 expression, TLR3 signaling or inhibition of TLR4 pathway, 2./ to restore the immune dysregulation by inhibition of pro-inflammatory cytokines (TNF-, IL-6, IL-13, IL-17, IL-18, IL-21), Th1 polarisation (IL-2, IL-12, IL-23, IFN-), T-cell activation, leukocyte adhesion, as well as by immunostimulation (GM-CSF, G-CSF) and anti-inflammatory cytokines (IL-10, IL-11, IFN--1a), 3./ to restore mucosal barrier function and stimulate mucosal healing by different growth factors, such as GH, EGF, KGF, TGF-, VEGF, 4./ to restore the normal bacterial flora by antibiotics, probiotics. However, in spite of these numerous potential targets, the true value and clinical significance of most of the new biologics and molecules are not clear yet.

show abstract

“…Moreover, a defective mucus layer has been associated with UC in humans and colitis in mice [40,80,81]. Additionally, an increased number of epithelium-associated bacteria have been found in IBD, although more consistently in CD than UC [82,83]. Finally, our pharmacogenetics studies of gene-environment interactions in relation to development of colorectal cancer, suggest that intake of red and processed meat interacts with genes encoding TLRs and NF-κB [84], which may offer a potential link to anti-TNF treatment response.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that plant fibre may be important for restoring the mucus layer [40,82]. Supplementation with complex oligosaccharides such as those present in soluble edible plant fibres was able to inhibit the adherence of pathogen bacteria to epithelial cells in a hen model [73].…”

Section: Discussionmentioning

confidence: 99%

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Andersen¹,

Hansen²,

Heitmann³

2017

Preprint

View full text Add to dashboard Cite

Abstract:We wanted to investigate the current knowledge on the impact of diet on anti-TNF response in inflammatory bowel diseases (IBD), to identify dietary factors that warrant further investigations in relation to anti-TNF treatment response, and, finally, to discuss potential strategies for such investigations. PubMed was searched using specified search terms. One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73-4.31, p < 0.01, OR 2.93; 95% CI: 1.66-5.17, p < 0.01, respectively). In conclusion, evidence-based knowledge on impact of diet on anti-TNF treatment response for clinical use is scarce. Here we propose a mechanism by which Western style diet high in meat and low in fibre may promote colonic inflammation and potentially impact treatment response to anti-TNF drugs. Further studies using hypothesis-driven and data-driven strategies in observational, animal and interventional studies are warranted.

show abstract

Bacteria in the pathogenesis of inflammatory bowel disease

Cited by 40 publications

References 66 publications

Prevalence of Adherent-Invasive Escherichia coli with fimH Gene Isolated from Iranian Patients with Ulcerative Colitis

Prevalence of Adherent-Invasive Escherichia coli with fimH Gene Isolated from Iranian Patients with Ulcerative Colitis

Gut Inflammation: Current Update on Pathophysiology, Molecular Mechanism and Pharmacological Treatment Modalities

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Contact Info

Product

Resources

About