Bacteria and wound healing

Abstract

An appreciation of the factors affecting the progression from colonization to infection can help clinicians with the interpretation of clinical findings and microbiological investigations in patients with chronic wounds. An understanding of the physiology and interactions within multi-species biofilms may aid the development of more effective methods of treating infected and poorly healing wounds. The emergence of consensus guidelines has helped to optimize clinical management.

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

“…Chronic wounds are defined as those which do not follow the normal healing process and show no signs of effective healing within 3 months after the tissue injury [4]. The features characteristic for the chronic wounds are prolonged or excessive inflammatory phase [5], overabundant neutrophil infiltration [6], persistent infections [7], and frequent formation of tissue/organ atypical biofilms [8,9].…”

Garlic ointment inhibits biofilm formation by bacterial pathogens from burn wounds

“…Biofilms are embedded in a glycocalyx, which is a combination of bacterial secreted extracellular polysaccharides that form a protective matrix adhering to the host's surrounding tissues (Stoodley et al, 2002;Sutherland, 2001). Biofilms are, therefore, highly resistant to host immune responses and antibiotics (Costerton et al, 1999;Donlan & Costerton, 2002;Donlan, 2011) and failure to eradicate biofilms leads to persistent infections (Costerton et al, 1999;Edwards & Harding, 2004). Previous studies have documented the production of bacterial biofilms at a range of infection sites and on a variety of different medical devices (Donlan & Costerton, 2002;Donlan, 2011;Macleod & Stickler, 2007).…”

Phytochemical and Antibacterial Evaluations of the Stem Bark of <i>Newbouldia laevis</i> against Isolates from Infected Wounds and Eyes

“…Wound infection is detrimental to wound healing which is a complex process that can be delayed by many potential factors [10] . A variety of disorders commonly affect the eye and vary in severity from mild but annoying allergic conjunctivitis to sight threatening infections [11] .…”