Bacteremia Increases the Risk of Death among Patients with Soft-Tissue Infections

Micek, Scott T.; Hoban, Alex; Pham, Victor; Doherty, Joshua A.; Zilberberg, Marya D.; Shorr, Andrew F.; Kollef, Marin H.

doi:10.1089/sur.2009.007

Cited by 15 publications

(11 citation statements)

References 17 publications

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“…linezolid, ceftaroline, telavancin, daptomcyin, tigecycline) have come to market by gaining indication for treatment of SSTIs. Moreover, there are now recognized subpopulations of patients with SSTIs who are at increased risk of bacteremia necessitating more aggressive and prolonged therapy [ 16 , 17 ].…”

Section: Scope Of the Problemmentioning

confidence: 99%

Treatment of gram - positive infections in critically ill patients

Guillamet

Kollef

2014

BMC Infect Dis

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Gram-positive bacteria to include methicillin-resistant Staphylococcus aureus (MRSA), methicillin-susceptible Staphylococcus aureus (MSSA), and enterococci, to include vancomycin-resistant enterococci (VRE), display a remarkable array of resistance and virulence factors, which have contributed to their prominent role in infections of the critically ill. Over the last three decades infections with these pathogens has increased as has their overall resistance to available antimicrobial agents. This has led to the development of a number of new antibiotics for the treatment of Gram-positive bacteria. At present, it is important that clinicians recognize the changing resistance patterns and epidemiology of Gram-positive bacteria as these factors may impact patient outcomes. The increasing range of these pathogens, such as the emergence of community-associated MRSA clones, emphasizes that all specialties of physicians treating infections should have a good understanding of the infections caused by Gram-positive bacteria in their area of practice. When initiating empiric antibiotics, it is of vital importance that this therapy be timely and appropriate, as delays in treatment are associated with adverse outcomes. Although vancomycin has traditionally been considered a first-line therapy for serious MRSA infections, multiple concerns with this agent have opened the door for alternative agents demonstrating efficacy in this role. Similarly, the expansion of VRE as a pathogen in the ICU setting has required the development of agents targeting this important pathogen.

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Section: Scope Of the Problemmentioning

confidence: 99%

Treatment of gram - positive infections in critically ill patients

Guillamet

Kollef

2014

BMC Infect Dis

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“…1 Patients with more frequent complication of SSSI, 7 " 10 recent data suggest that it severe SSSIs, however, require hospitalization, and cellulitis occurs in 15%-19% of patients, 11 " 15 most often in those with and abscess account for approximately 600,000 hospital dis-severe infections 1617 or comorbidities. 14,15 Recent studies also charges annually in the United States. 2 In fact, SSSIs were suggest that bacteremia is an independent risk factor for moramong the most rapidly increasing causes for hospitalization tality in patients with soft-tissue infections.…”

Section: Infect Control Hosp Epidemiol 2010; 31(8):828-837mentioning

confidence: 99%

Predicting Bacteremia among Patients Hospitalized for Skin and Skin-Structure Infections: Derivation and Validation of a Risk Score

Lipsky

Kollef

Miller

et al. 2010

Infect. Control Hosp. Epidemiol.

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“…The population of interest consisted of patients hospitalized with CO-ABSSSI diagnosed within 48 h of admission, as previously defined [ 16 ] between January 2010 and December 2015. Patients were excluded if they had any of the following concomitant diagnoses because these infections tend to have a higher likelihood of poor patient outcomes irrespective of concomitant BSI: [ 17 ] osteomyelitis, septic arthritis, prosthetic device-related infection, an animal or human bite, burn, necrotizing fasciitis, pyomyositis, or ABSSSI secondary to recent (within 2 weeks) surgery. Cases were defined as inpatients with at least one positive blood culture meeting the Center for Disease Control and Prevention (CDC) BSI criteria [ 18 ] collected within 48 h of admission and in whom ABSSSI was documented as the primary source.…”

Section: Methodsmentioning

confidence: 99%

“…The a priori minimum sample size for this unmatched 1:1 case-control study was calculated using the statistical test for differences in proportions [ 21 ]. A sample size of 187 case and 187 control subjects was required to achieve 80% power at a 0.05 significance level to detect an adjusted odds ratio (aOR) of ≥ 2 for a risk factor with a known prevalence of 10–20% (diabetes, renal failure, prior antibiotics, recurrent infection) [ 17 , 22 – 24 ].…”

Section: Methodsmentioning

confidence: 99%

Risk Factors for Bloodstream Infections Among an Urban Population with Skin and Soft Tissue Infections: A Retrospective Unmatched Case-Control Study

et al. 2018

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Introduction The prevalence of acute bacterial skin and skin structure infections (ABSSSIs) continues to increase. Bloodstream infection (BSI) is a severe secondary complication of ABSSSI. The objective of this study was to determine clinical and sociodemographic risk factors for BSI in patients with acute bacterial skin and skin structure infections (ABSSSIs) and to determine if sociodemographic factors impact severity at presentation. Methods This was a retrospective unmatched (1:1) case-control study. Predictors of BSI and severe infection were sought through multivariable logistic regression analyses. Cases and controls were collected from two major medical centers located in downtown Detroit, Michigan: the Detroit Medical Center and the Henry Ford Health System. The population of interest included adult patients with community-onset (CO) ABSSSI treated at a participating hospital between January 2010 and December 2015. Cases were defined as those developing BSI within 48 h of admission with CO-ABSSSI as the primary source, while controls were those with CO-ABSSSI without BSI. Results A total of 392 patients (196 cases, 196 controls) were included. Independent predictors of BSI were male gender (aOR 1.85: 95% CI 1.11, 3.66), acute renal failure (aOR 2.08: 95% CI 1.18, 3.66), intravenous drug use (aOR 4.38, 95% CI 2.22, 8.62), and prior hospitalization (aOR 2.41, 95% CI 1.24, 4.93). African American race (aOR 2.18, 95% CI 1.38, 3.4), leukocytosis (aOR 2.24, 95% CI 1.41, 3.55), and prior hospitalization (aOR 2.07, 95% CI 1.19, 3.00) were significantly associated with infection severity. Conclusion Both clinical and sociodemographic factors were associated with BSI and severe infection underscoring the importance of social determinants of health in outcomes among underserved populations.

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Bacteremia Increases the Risk of Death among Patients with Soft-Tissue Infections

Cited by 15 publications

References 17 publications

Treatment of gram - positive infections in critically ill patients

Treatment of gram - positive infections in critically ill patients

Predicting Bacteremia among Patients Hospitalized for Skin and Skin-Structure Infections: Derivation and Validation of a Risk Score

Risk Factors for Bloodstream Infections Among an Urban Population with Skin and Soft Tissue Infections: A Retrospective Unmatched Case-Control Study

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