Bacteraemia and breast abscess: unusual extra-intestinal manifestations of Clostridium difficile infection

Durojaiye, Oyewole Christopher; Gaur, Smriti; Alsaffar, Layth

doi:10.1099/jmm.0.027409-0

Cited by 13 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clostridium difficile always causes antimicrobialassociated diarrhea. Extracolonic C. difficile infection is rare, and the manifestations include osteomyelitis (3), visceral abscess, reactive arthritis (4), and breast abscess (5). Clostridium difficile bacteremia is rarely reported.…”

Section: Discussionmentioning

confidence: 99%

“…For the two strains, from blood and stool, the same toxin profile was observed, ST type and antibiotic susceptibility pattern. The cases of Clostridium bacteremia similar to the current one were reviewed in the PubMed database and listed in Table 1 (5,9,10) and Table 2 (10-14) for comparison.…”

Section: Discussionmentioning

confidence: 99%

“…Extraintestinal infections caused by these bacteria are rarely reported, and the reported manifestations include osteomyelitis (3), reactive arthritis (4), breast abscess (5) and C. difficile bacteremia (6). The current report was on a patient with recurrent abdominal pain and fever associated with appendiceal perforation and abscess and cirrhosis; he developed C. difficile bacteremia during hospitalization with microbiological evidence, and underwent subsequent antimicrobial therapy.…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Molecular Characterization and Antibiotic Profile of Clostridium difficile Isolated from Bacteremia

Fang

Chen

et al. 2019

Jundishapur J Microbiol

View full text Add to dashboard Cite

Introduction:Clostridium difficile infection always manifests as diarrhea associated with antibiotic use. Nevertheless, extraintestinal infections caused by C. difficile are reported. The current report was on a case of C. difficile bacteremia in a 51-year-old male patient with appendiceal perforation and abscess as well as confirmed cirrhosis. Case Presentation: The patient was admitted to the infectious diseases department with repeated abdominal pain associated with fever. His anaerobic blood culture was positive for C. difficile two days after transarterial chemoembolization. The same toxin strain was isolated from stool four days later. Both of the two isolates were confirmed positive for toxin A (tcd A) and toxin B (tcd B) genes by polymerase chain reaction, and identified as ST3 by multiple locus sequence typing. The two strains showed the same susceptibility to the tested antibiotics. The patient was treated with vancomycin intravenously, and got remitted shortly after that. The patient was discharged with good general health conditions and followed up. Conclusions: A patient with C. difficile bacteremia presenting with appendiceal perforation and abscess as well as confirmed cirrhosis was described, and the microbiological and molecular biological analysis suggested that C. difficile strains isolated from blood came from gut. It is necessary that clinicians detect C. difficile and/or toxins in patients with long terms antibiotic therapy, in case of transformation of intestinal flora, which could cause the infection outside the intestinal tract.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Molecular Characterization and Antibiotic Profile of Clostridium difficile Isolated from Bacteremia

Fang

Chen

et al. 2019

Jundishapur J Microbiol

View full text Add to dashboard Cite

show abstract

“…Gérard et al characterized a serogroup C strain and McGill et al reported two ribotype 106 strains and one ribotype 001 [36], [47]. Another case report detected a ribotype 106 from bacteremia and breast abscess [48]. One of two bacteremia cases recently reported by Hemminger et al was due to the epidemic and hypervirulent NAP1 strain (027/BI, toxinotype III, binary toxin-positive), and the other was due to NAP-4 [49].…”

Section: Systematic Reviewmentioning

confidence: 99%

Clostridium difficile bacteremia: Report of two cases in French hospitals and comprehensive review of the literature

Doufair

Eckert

Drieux

et al. 2017

IDCases

View full text Add to dashboard Cite

We report two cases of bacteremia due to Clostridium difficile from two French hospitals. The first patient with previously diagnosed rectal carcinoma underwent courses of chemotherapy, and antimicrobial treatment, and survived the C. difficile bacteremia. The second patient with colon perforation and newly diagnosed lung cancer underwent antimicrobial treatment in an ICU but died shortly after the episode of C. difficile bacteremia. A review of the literature allowed the identification of 137 cases of bacteremia between July 1962 and November 2016. Advanced age, gastro-intestinal disruption, severe underlying diseases and antimicrobial exposure were the major risk factors for C. difficile bacteremia. Antimicrobial therapy was primarily based on metronidazole and/or vancomycin. The crude mortality rate was 35% (21/60).

show abstract

“…Extra-intestinal manifestation of C. difficile had been reported in the form of bacteremia (Feldman et al 1995;García-Lechuz et al 2001;Jacobs et al 2001;Libby and Bearman 2009;Choi et al 2013;Shah et al 2017), abscesses (Durojaiye et al 2011;Ulger Toprak et al 2016;Roy et al 2017), and rarely had also been associated with osteomyelitis (Riley and Karthigasu 1982;Towns et al 1984;Incavo et al 1988;Pron et al 1995;Gaglani et al 1996;García-Lechuz et al 2001;Bachmeyer et al 2008;Al-Najjar et al 2013;Curtis and Lipp 2013;Ranganath and Midturi 2013). Two previous cases of C. difficile chronic osteomyelitis were reported among sickle cell patients (Gaglani et al 1996;Bachmeyer et al 2008).…”

mentioning

confidence: 99%

Multi-focal Clostridioides (Clostridium) difficile osteomyelitis in a patient with sickle cell anemia: case presentation and literature review

Al‐Tawfiq

Babiker

2020

Diagnostic Microbiology and Infectious Disease

View full text Add to dashboard Cite

Clostridium difficile infection manifests as intestinal infections, namely pseudomembranous colitis. The occurrence of extra-intestinal disease is thought to be rare with a rate of 1.08% of 2034 isolates of C. difficile and an incidence of 4/100,000 admissions. C. difficile had been rarely associated with osteomyelitis. Here, we report the occurrence of C. difficile infection in a patient with sickle cell disease. The patient had multiple surgeries and a prolonged antimicrobial therapy to achieve a cure. The patient had C. difficile infection of native bone and of a prosthetic joint. The patient received prolonged therapy with amoxicillin-clavulanic acid and metronidazole and she remained free of C. difficile infection for three years off antibiotics.

show abstract

Bacteraemia and breast abscess: unusual extra-intestinal manifestations of Clostridium difficile infection

Cited by 13 publications

References 16 publications

Molecular Characterization and Antibiotic Profile of Clostridium difficile Isolated from Bacteremia

Molecular Characterization and Antibiotic Profile of Clostridium difficile Isolated from Bacteremia

Clostridium difficile bacteremia: Report of two cases in French hospitals and comprehensive review of the literature

Multi-focal Clostridioides (Clostridium) difficile osteomyelitis in a patient with sickle cell anemia: case presentation and literature review

Contact Info

Product

Resources

About