Bacosides Encapsulated in Lactoferrin Conjugated PEG-PLA-PCL-OH Based Polymersomes Act as Epigenetic Modulator in Chemically Induced Amnesia

Identification of Caffeic Acid Phenethyl Ester (CAPE) as a Potent Neurodifferentiating Natural Compound That Improves Cognitive and Physiological Functions in Animal Models of Neurodegenerative Diseases

“…Neural stem cell proliferation and differentiation have been shown to acquire long-lasting gene expression changes that are tightly regulated by transcriptional machinery and epigenetic modifications (Feng et al, 2007). Similarly, we had earlier demonstrated that the memory impairing potential of SC is primarily attributed to epigenetic modifications and transcriptional control of memory markers like BDNF in mouse model (Singh et al, 2015;Goyal et al, 2020). Therefore, modulated transcript expressions of the BDNF, Nestin, and NeuN in SC-induced amnesic mice model affirmed impact of the SC on transcriptional control, deteriorating the cognitive behavior and memory function (Figure 5).…”

Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders

“…It was observed that scopolamine‐induced anterograde and retrograde amnesia by decreasing protein kinase C (PKC) and iNOS (NO synthases inducible isoform), which was reversed by the B. monniera extract by ameliorating calmodulin and attenuating phosphorylated CREB and kinase C (Saraf, Anand, & Prabhakar, 2010; Saraf, Prabhakar, Khanduja, & Anand, 2011). In another study comparing the neuroprotective effects of bacoside‐rich fraction of B. monnieri (bacoside) to bacoside encapsulated in lactoferrin conjugated PEG–PLA‐PCL‐OH‐based polymersomes (BAN) toward scopolamine‐induced amnesia, and found that BAN was more efficient due to the specific delivery of bacoside to overcome BBB through polymersomes, via receptor‐mediated endocytosis (Goyal, Konar, Kumar, & Koul, 2020). Bacopa monnieri also altered the diazepam (DP)‐induced amnesia by reducing the escape latency time (Saraf et al, 2008).…”