Backflushing and Two-Stage Operation of Capillary Columns in Gas Chromatography.

McEwen, D. J.

doi:10.1021/ac60208a012

Cited by 33 publications

(4 citation statements)

References 11 publications

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“…A more effective way to enhance resolving power is through multidimensional gas chromatography (MDGC), a method introduced more than 40 years ago (McEwen, 1964). Conventional ''heart-cutting'' MDGC instrumentation enables the transfer of selected bands of overlapping compounds from a primary to a secondary column, connected by means of an interface (either a switching valve or a Deans switch).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive two‐dimensional gas chromatography‐mass spectrometry: A review

Mondello

Tranchida

Dugo

et al. 2008

Mass Spectrometry Reviews

379

216

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Although comprehensive two-dimensional gas chromatography (GC Â GC) has been on the scene for more than 15 years, it is still generally considered a relatively novel technique and is yet far from being fully established. The revolutionary aspect of GC Â GC, with respect to classical multidimensional chromatography, is that the entire sample is subjected to two distinct analytical separations. The resulting enhanced separating capacity makes this approach a prime choice when GC analysts are challenged with highly complex mixtures. The combination of a third mass spectrometric dimension to a GC Â GC system generates the most powerful analytical tool today for volatile and semi-volatile analytes. The present review is focused on the rather brief, but not scant, history of comprehensive two-dimensional GC-MS: the first experiments were carried out at the end of the 1990s and, since then, the methodology has been increasingly studied and applied. Almost all GC Â GC-MS applications have been carried out by using either a time-of-flight or quadrupole mass analyzer; significant experiments relative to a variety of research fields, as well as advantages and disadvantages of the MS systems employed, are discussed. The principles, practical and theoretical aspects, and the most significant developments of GC Â GC are also described. #

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Section: Introductionmentioning

confidence: 99%

Comprehensive two‐dimensional gas chromatography‐mass spectrometry: A review

Mondello

Tranchida

Dugo

et al. 2008

Mass Spectrometry Reviews

379

216

View full text Add to dashboard Cite

show abstract

“…Conventional , heart-cutting' multidimensional GC (MDGC) was introduced to the separation science com- munity more than 40 years ago [54]. This methodology is based, essentially, on the transfer of selected effluent fractions from a first to a second column.…”

Section: Narrow-bore Columnsmentioning

confidence: 99%

Rapid analysis of food products by means of high speed gas chromatography

Donato

Tranchida

Dugo

et al. 2007

J of Separation Science

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ReviewRapid analysis of food products by means of high speed gas chromatographySince the invention of GC, there has been an ever increasing interest within the chromatographic community for faster GC methods. This is obviously related to the fact that the number of samples subjected to GC analysis has risen greatly. Nowadays, in routine analytical applications, sample throughput is often the most important aspect considered when choosing an analytical method. Gas chromatographic instrumentation, especially in the last decade, has been subjected to continuous and considerable improvement. High-speed injection systems, electronic gas pressure control, rapid oven heating/cooling and fast detection are currently available in a variety of commercial gas chromatographs. The main consequence of this favourable aspect is that high-speed GC is being increasingly employed for routine analysis in different fields. Furthermore, the employment of dedicated software makes the passage from a conventional to a fast GC method a rather simple step. The present review provides an overview of the employment of fast GC techniques for the analysis of food constituents and contaminants. A brief historical and theoretical background is also provided for the approaches described.

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“…A six-port carrier-gas flow-switching valve was designed to allow backflushing of capillary columns and use in a two-stage operation of two capillary columns or a combination of capillary and packed columns (429).…”

Section: Chamberlain Andmentioning

confidence: 99%