Backbone flexibility/amphiphilicity modulation of AIE active polyelectrolytes for mitochondria- and nucleus-targeted synergistic photodynamic therapy of cancer cells

He, Zhiguo; Han, Xianbo; Yan, Zifeng; Guo, Bing; Cai, Qiang; Yao, Youwei

doi:10.1039/d2qm00761d

Cited by 1 publication

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References 85 publications

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“…AIE fluorogens (AIEgens) emit significant fluorescence due to the restriction of intramolecular motion (RIM) in aggregate states. To date, increasing reported AIE PSs were derived from skeletons such as tetraphenylethylene (TPE) or triphenylamine (TPA) [33][34][35][36][37]. This suspension was filtrated, and washed with water and methanol.…”

Section: Introductionmentioning

confidence: 99%

Precise ligand engineering of Ir(III)‐based photosensitizer with aggregation‐induced emission for image‐guided photodynamic therapy

Tong,

Liu,

Huang

et al. 2023

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Photodynamic therapy (PDT), which relies on the production of reactive oxygen species (ROS) induced by a photosensitizer to kill cancer cells, has become a non‐invasive approach to combat cancer. However, the conventional aggregation‐caused quenching effect, as well as the low ROS generation ability of photosensitizers, restrict their biological applications. In this work, a new Ir(III) complex with a dendritic ligand has been strategically designed and synthesized by ingenious modification of the ancillary ligand of a reported Ir(III) complex (Ir‐1). The extended π‐conjugation and multiple aromatic donor moieties endow the resulting complex Ir‐2 with obvious aggregation‐induced emission (AIE) activity and bathochromic emission. In in vitro experiments, importantly, Ir‐2 nanoparticles exhibit the excellent photoinduced ROS generation capabilities of O2•− and 1O2, as well as excellent biocompatibility and the lipid droplets (LDs) targeting feature. This study would provide useful guidance to design efficient Ir(III)‐based photosensitizers used in biological applications in the future.

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Section: Introductionmentioning

confidence: 99%

Precise ligand engineering of Ir(III)‐based photosensitizer with aggregation‐induced emission for image‐guided photodynamic therapy

Tong,

Liu,

Huang

et al. 2023

Luminescence

View full text Add to dashboard Cite

show abstract

Backbone flexibility/amphiphilicity modulation of AIE active polyelectrolytes for mitochondria- and nucleus-targeted synergistic photodynamic therapy of cancer cells

Abstract: Mitochondria and nucleus targeted photodynamic therapy (PDT) to locally destruct organelles which play vital roles in physiologic processes holds great promise for PDT. Notably, the emerging polymeric photosensitizers with multiple...

Cited by 1 publication

References 85 publications

Precise ligand engineering of Ir(III)‐based photosensitizer with aggregation‐induced emission for image‐guided photodynamic therapy

Precise ligand engineering of Ir(III)‐based photosensitizer with aggregation‐induced emission for image‐guided photodynamic therapy

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