Back to the Future: Looking at the Skin to Predict Death—A Lesson from Psoriasis

Naldi, Luigi; Pezzolo, Elena

doi:10.1016/j.jid.2017.08.027

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…It is worth to note that, in spite of increasing incidence, we found a progressive reduction in the lifetime prevalence of psoriasis after age 64, suggesting a potentially higher mortality rate among psoriasis patients, compared to the general population, leading to a depletion of psoriasis patients from the older age population sectors. This is also supported by an increasing body of evidence in favour of a higher, all-cause mortality in psoriasis patients, particularly in those with severe disease, compared with the general population (12)(13)(14). The systemic inflammatory process of severe psoriasis, protracted over time seems to, at least partially, play a role in the potential direct link between psoriasis and increased mortality (13).…”

Section: Discussionmentioning

confidence: 87%

“…This is also supported by an increasing body of evidence in favour of a higher, all-cause mortality in psoriasis patients, particularly in those with severe disease, compared with the general population (12)(13)(14). The systemic inflammatory process of severe psoriasis, protracted over time seems to, at least partially, play a role in the potential direct link between psoriasis and increased mortality (13).…”

Section: Discussionmentioning

confidence: 87%

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Psoriasis Incidence and Lifetime Prevalence: Suggestion for a Higher Mortality Rate in Older Age-classes among Psoriatic Patients Compared to the General Population in Italy

Pezzolo¹,

Cazzaniga²,

Colombo³

et al. 2019

Acta Derm Venerol

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SIGNIFICANCELittle is known about psoriasis incidence and prevalence in Italy. Such information is important in order to define the disease burden. Therefore, an accurate and timely understanding of the disease epidemiology is needed. We investigated incidence rates and lifetime prevalence of psoriasis in a representative sample of adult Italian population, assessing the disease history through a face-to-face interview. We documented a bimodal distribution pattern in the incidence. We also observed a decrease in the lifetime prevalence after age 64. This suggests a higher mortality rate in older psoriasis patients compared to the general population.Data on the psoriasis incidence and prevalence in the Italian population are limited, and a timely and accurate understanding of the disease epidemiology is needed. This ad hoc study investigated psoriasis incidence and lifetime prevalence in a representative sample (n = 14,705) of the Italian population. Information on lifetime history of skin disorders with details about their onset, duration, and treatment was collected. Psoriasis incidence showed a bimodal distribution pattern, with peaks in age classes characteristic of early-onset (35-44 years) and late-onset (65-74 years) psoriasis. Late-onset psoriasis showed some variations according to the sex, with females being diagnosed earlier than males. Lifetime prevalence of psoriasis was 2.7% (95% confidence interval: 2.5-3.0): it increased to 3.5% at age 60-64 years, then decreased steadily after age 64, to 1.7% at age > 74 years. This decrease, despite a peak in incidence rates, after age 64, may suggest a higher mortality rate among psoriasis patients in older age classes, compared to the general population. ActaDV ActaDV Advances in dermatology and venereologyActa Dermato-Venereologica 401 Psoriasis epidemiology suggestion for older age-classes higher mortality Acta Derm Venereol 2019 ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica 403 Psoriasis epidemiology suggestion for older age-classes higher mortality Acta Derm Venereol 2019

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