Psoriasis severity matters when dealing with all-cause mortality in psoriasis patients: a record linkage analysis in Northern Italy

Pezzolo, Elena; Ciampichini, Roberta; Cazzaniga, Simone; Sampietro, Giuseppe; Zucchi, Alberto; Naldi, Luigi

doi:10.1007/s00403-020-02101-1

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…Mean age of the studied cases was 56.59 ± 10.67 years versus 56.59 ± 9.71 years for control group. This mean age was in accordance with Pezzolo et al (13) which was 59.7 ± 12.3 & 60.8 ± 16.3 years respectively.…”

Section: Discussionsupporting

confidence: 91%

Assessment of Serum Level of Adipocyte Fatty Acid Binding Protein in Patients with Psoriasis Vulgaris before and after Treatment with Acitretin

Darwish¹,

Dakrory²,

Hendawy

2022

The Egyptian Journal of Hospital Medicine

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Background: Psoriasis is a common immune mediated and chronic inflammatory skin disorder portrayed as hyperproliferation and maturation impairment of keratinocytes, increased immune cells infiltration and blood vessel formation, and accumulation in proinflammatory cytokines. Psoriasis is now considered a systemic disease where it is associated with psychological, metabolic, arthritic, and cardiovascular comorbidities. Lifespan is reduced as a consequence.Objective: The aim of this study was to evaluate serum level of adipocyte fatty acid-binding protein (FABP4) in patients with psoriasis vulgaris and to compare it with its level in healthy control. Patients and methods: Seventy-four were included in this study. They were chosen from the Out-patient Clinic of Dermatology, Andrology & STDs Department, Mansoura University Hospitals. A case study group of 37 patients with psoriasis vulgaris and 37 of healthy people age-and sex-matched were used as a control group. Results: ROC curve for detection of FABP4 before acitretin validity in differentiating studied cases illustrated excellent area under curve of 0.728 (p < 0.001)* with the best detected cut off point was 2.7 yielding sensitivity of 75%, specificity of 81.1% and total accuracy of 78.1%. So, the present study demonstrated that; detection of FABP4 level before acitretin therapy could be used as reliable indicator in differentiating studied cases with high sensitivity and specificity. Conclusions: Serum FABP4 levels were significantly increased in patients with psoriasis, indicating that this protein may be a potential marker of psoriasis and an independent predictor for the risk of comorbidities or complications in psoriatic patients. Additionally, it could be used also as a reliable indicator of acitretin therapy.

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Section: Discussionsupporting

confidence: 91%

Assessment of Serum Level of Adipocyte Fatty Acid Binding Protein in Patients with Psoriasis Vulgaris before and after Treatment with Acitretin

Darwish¹,

Dakrory²,

Hendawy

2022

The Egyptian Journal of Hospital Medicine

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“…This study provides valuable evidence for researchers to investigate the real-world outcomes and utilization of biological drugs approved for IMIDs, enabling the identification of indications of use from Italian claims data. Other validation studies, 19,23,24,32 which were considered for the development of the META-algorithm, were aimed to develop and validate a coding algorithm for the identification of a single IMID in the general population; however, to the best of our knowledge, no previous studies developed and validated a coding algorithm, using claims data, to correctly identify the correct indication of use for biological drug users (eg TNF-alpha inhibitors, anti-interleukin, and selective immunosuppressants), which are approved for IMID treatment. As indication of use is typically not specifically reported in the claims database, the findings of this study can help the conduction of future observational studies on biological drugs in IMID patients by identifying the correct indication of use.…”

Section: Discussionmentioning

confidence: 99%

“…Based on published articles, coding algorithms to ascertain IMIDs (RA, SpA, PsO, PsA, CD, CU, HS, and uveitis) from claims Italian databases were identified. 19,[23][24][25][26][27][28][29][30][31] It was decided to consider only algorithms validated in Italy as those developed using claims databases from other countries may not be directly applicable to the Italian claims databases. 9 If no coding algorithms were previously validated in the Italian claims databases, then algorithms developed in other countries were considered.…”

Section: Identification Of Coding Algorithms For Single Imids From Th...mentioning

confidence: 99%

Development and Validation of a META-Algorithm to Identify the Indications of Use of Biological Drugs Approved for the Treatment of Immune-Mediated Inflammatory Diseases from Claims Databases: Insights from the VALORE Project

Spini,

L'Abbate,

Ingrasciotta

et al. 2024

CLEP

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This research aimed to develop and validate a META-algorithm combining individual immune-mediated inflammatory disease (IMID)-specific algorithms to identify the exact IMID indications for incident biological drug users from claims data within the context of the Italian VALORE project. Methods and Patients: All subjects with at least one dispensing of TNF-alpha inhibitors, anti-interleukin agents, and selective immunosuppressants approved for IMIDs were identified from claims databases of Latium region in Italy (observation period: 2010-2020). Validated coding algorithms for identifying individual IMIDs from claims databases were found from published literature and combined into a META-algorithm. Positive predictive value (PPV), sensitivity (Se), negative predictive value (NPV), specificity (Sp), and accuracy (Acc) were estimated for each indication against the electronic therapeutic plans (ETPs) of the Latium region as the reference standard. Lastly, the frequency of the indication of use across individual biologic drugs was compared with that reported in three other Italian regions (Lombardy, Apulia, and the Veneto region). Results: In total, 9755 incident biological drug users with a single IMID indication were identified. Using the newly developed META-algorithm, an indication of use was detected in 95% (n=9255) of the total cohort.

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“…A recent Italian study reported as high as 98.9% PPV for psoriasis when using either a dermatologist’s diagnosis or psoriasis medications as search criteria ( 5 ). A recent Danish study found a PPV of 97.1% among patients treated in tertiary referral dermatology clinics ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

Validation of Psoriasis Diagnoses Recorded in Finnish Biobanks

et al. 2020

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Psoriasis severity matters when dealing with all-cause mortality in psoriasis patients: a record linkage analysis in Northern Italy

Cited by 6 publications

References 36 publications

Assessment of Serum Level of Adipocyte Fatty Acid Binding Protein in Patients with Psoriasis Vulgaris before and after Treatment with Acitretin

Assessment of Serum Level of Adipocyte Fatty Acid Binding Protein in Patients with Psoriasis Vulgaris before and after Treatment with Acitretin

Development and Validation of a META-Algorithm to Identify the Indications of Use of Biological Drugs Approved for the Treatment of Immune-Mediated Inflammatory Diseases from Claims Databases: Insights from the VALORE Project

Validation of Psoriasis Diagnoses Recorded in Finnish Biobanks

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