Back Cover Image, Volume 92, Number 11, November 2020

Abstract

Back Cover Caption: The cover image is based on the Research Article SARS‐CoV‐2 and SARS‐CoV: Virtual Screening of Potential inhibitors targeting RNA‐dependent RNA polymerase activity (NSP12) by Zijing Ruan et al., https://doi.org/10.1002/jmv.26222.

Comparative assessment of RNA-dependent RNA polymerase (RdRp) inhibitors under clinical trials to control SARS-CoV2 using rigorous computational workflow

“…17 There are reports, where the same protein with different PDB id has been used for bioinformatic studies, which are 6NUR and 7BW4. 15,33,34 However, these RdRp structures do not possess any cocrystallized inhibitor, had lower resolution than 7AAP, and lacked a chain or two, therefore the protein 7AAP was chosen to perform all the following studies.…”

“…While the non-nucleotide inhibitor does not require such activation and upon gaining entry into the cell, they directly bind at the active site or at the allosteric site of RdRp halting its normal functioning. 11,15 Despite several RdRp inhibitors already being under clinical trials, their comparative assessment, at least a theoretical model is missing. The current work depicts the ndings of in silico research to ll this loophole.…”