Back Cover Image, Volume 39, Issue 5

Abstract

Description of the back cover image: The cover image is based on the Review Article Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study by Hongxun Tao et al., https://doi.org/10.1002/med.21564. Cover image © Hongxun Tao, Xu Wu, Shengpeng Wang, Prof. Yitao Wang.

Geraniol-Derived Monoterpenoid Glucosides from Rhodiola rosea: Resolving Structures by QM-HifSA Methodology

“…1−3 The genus Rhodiola is native to the Arctic regions of Europe, Asia, and North America and comprises over 200 species. 1,3,4 Phytochemical studies report R. rosea to be rich in cinnamyl alcohol glycosides, salidroside and its aglycone, monoterpenoid glycosides, benzyl alcohol glycosides, cyanogenic glycosides, and flavonoids. While cinnamyl alcohol glycosides and salidroside have been comprehensively investigated and are considered the bioactive constituents, some investigations suggest that geraniol-type monoterpenoids might play a critical role in the treatment of specific conditions, such as in depression and senile dementia.…”