Baccharis latifolia: una Asteraceae poco valorada con potencialidad química y biológica en el neotrópico

Abstract

Baccharis es un género de plantas muy numerosa (400-500 especies) altamente distribuidas en el neotrópico, dentro de las que se encuentra B. latifolia (Ruiz & Pav.) Pers. Esta planta presenta diversos usos en medicina tradicional en América Latina, dentro de los cuales se destaca usos analgésicos y antiinflamatorios, los cuales ha sido objeto de estudios adicionales que se han encauzado en su validación. Sin embargo, no hay una conexión importante entre las propiedades medicinales o farmacológicas con la composición química, salvo aquellos casos donde se justifica la actividad con otros estudios donde se aíslan compuestos que poseen actividad. Por tanto, el escenario indica que, pese a que existe información importante, los datos son marginales o separados entre sí, lo que permite justificar que es todavía importante estudios adicionales con fines quimioprospectivos. Por consiguiente, en el presente trabajo se describe, de forma generalizada, la información reportada a la fecha en estudios químicos y biológicos de la familia Asteraceae, del género Baccharis y de la especie B. latifolia, la cual, pese a tener un potencial claro en el neotrópico, es una planta poco conocida y valorada que merece mucha atención.

Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia

“…The species belonging to the Asteraceae family are characterized by their abundant biological activity [12], which results from their chemical composition, including secondary metabolites such as terpenes, diterpenes, flavonoids, and coumarins [13]. In the present study, two flavonoid compounds were isolated, 5,4 -dihydroxy-7-methoxyflavanone (1) and 5-hydroxy-7,4 -dimethoxyflavone (2).…”

“…In the NMR data of 13 C from compound 1 in the aliphatic zone 𝛿 (55.6 ppm), there appears a signal that belongs to a methoxy group. The signal in 𝛿 (43.1 ppm) is assigned to C-3 [26] and the signal in 103.5 ppm is assigned to C-10 of hydroxylated flavones, which are included in the structure of our compound and confirmed in the 1 H NMR spectrum.…”

Total Phenolic Composition and Antioxidant Activity of Silver Nanoparticles using Aqueous Extract of Chilca Leaves (Baccharis latifolia)

“…Dichloromethane extract of B. latifolia leaves promotes anti-inflammatory activity at doses of 300 mg . kg 1 , while acetone extract inhibits 89% of cancer cells in epithelial tissue (Prada et al, 2016;Calle et al, 2017). Derivatives of thymol (Kłeczek et al, 2019) and sesquiterpenes (Wang et al, 2019) have been found in its roots, while diterpenes from the labdane and germacrene nucleus (Zdero and Bohlmann, 1989) have been reported in the plant's upper part.…”

“…Derivatives of thymol (Kłeczek et al, 2019) and sesquiterpenes (Wang et al, 2019) have been found in its roots, while diterpenes from the labdane and germacrene nucleus (Zdero and Bohlmann, 1989) have been reported in the plant's upper part. Regarding its biological activity, its cytotoxic, antiproliferative, antifungal and anti-inflammatory effects have been studied (Abad et al, 2006;Sequeda-Castañeda et al, 2015;Prada et al, 2016).…”

Antinociceptive Effect of an Aqueous Extract and Essential Oil from Baccharis heterophylla

“…One of the medicinal species used in Capulálpam de Méndez for painful and inflammation disorders is Baccharis heterophylla Kunth (Asteraceae), a plant widely distributed in Mexico; the aerial parts of this species are consumed in the form of infusions, decoctions, or poultices [ 5 , 6 , 7 , 8 , 9 , 10 ]. Baccharis heterophylla is known as “chamizo de barrer”, “curacuata”, “jarakatua”, and “hierba de la mula”; among others, and it is also employed widely outside Oaxaca for treating painful complaints.…”