Baccaurea angulata fruit inhibits lipid peroxidation and induces the increase in antioxidant enzyme activities

Mikail, Maryam Abimbola; Ahmed, Idris Adewale; Ibrahim, Muhammad; Hazali, Norazlanshah; Rasad, Mohammad Syaiful Bahari Abdul; Ghani, Radiah Abdul; Hashim, Rosnani; Wahab, Ridhwan Abdul; Arief, Solachuddin Jahuari; Isa, Muhammad Lokman; Draman, Samsul; Yahya, Mohammad Noor Adros

doi:10.1007/s00394-015-0961-7

Cited by 19 publications

(14 citation statements)

References 57 publications

(56 reference statements)

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“…Besides the total energy intake, the diet composition also has a significant effect on the metabolic and endocrine functions as well as the overall energy balance (Dongiovanni et al, 2016). Therefore, the consumption of diets which are rich in fruits and vegetables is highly recommended for the prevention of oxidative damage and chronic disease (Mikail et al, 2016), and NAFLD is not an exception. Plants and plant-based natural products (such as fruit, vegetables, minimally-refined cereal, medicinal and aromatic plants) are sustainable antioxidant sources containing novel biologically active compounds such as phenolic compounds and vitamins with known beneficial effects (Ahmed and Mikail, 2017, Ahmed et al, 2015, Ahmed et al, 2017a, Ahmed et al, 2017b, Ibrahim et al, 2017a, Ibrahim et al, 2017b).…”

Section: Management Of Nafldmentioning

confidence: 99%

Lifestyle interventions for non-alcoholic fatty liver disease

Ahmed

Mikail

Mustafa

et al. 2019

Saudi Journal of Biological Sciences

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Non-alcoholic fatty liver disease (NAFLD) is a multi-factorial disease and the most common of chronic liver diseases worldwide. The four clinical-pathological entities which are usually followed by NAFLD course include non-alcoholic steatosis, non-alcoholic steatohepatitis, advanced fibrosis/cirrhosis, and hepatocellular carcinoma. The cornerstones of NAFLD management and treatment, however, are healthy lifestyles such as dietary modifications, regular physical activity, and gradual weight loss. At present, no drugs or pharmacological agents have been approved for long-term treatment of NAFLD. Therefore, lifestyle modification is considered the main clinical recommendation and an initial step for the management of NAFLD.

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Section: Management Of Nafldmentioning

confidence: 99%

Lifestyle interventions for non-alcoholic fatty liver disease

Ahmed

Mikail

Mustafa

et al. 2019

Saudi Journal of Biological Sciences

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“…These versatile health benefits exerted by B. angulata WF may be partly due to the fact that phenolic compounds which act as excellent antioxidants indirectly contribute to anti-inflammatory action. Baccaurea angulata WF that possessed the potential to minimize the generation of free radicals and displayed high antioxidant properties and protective effect against lipid peroxidation, a promoter of the atherosclerotic event [ 16 ], also interferes with the inflammatory stage of atherosclerosis. Our results are in accordance with a previous experimental study which showed that polyphenol-rich Euterpe oleracea Martius (Arecaceae), commonly known as açaí, possessed both antioxidant and anti-inflammatory properties through the reduction of lipid peroxidation, boosting of antioxidant enzymes, and inhibition of proinflammatory cytokine production [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Phenolic-Rich Baccaurea angulata Modulates Inflammatory Biomarkers of Atherosclerosis

Ibrahim

Mikail

Ahmed

et al. 2018

Journal of Nutrition and Metabolism

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Purpose Cardiovascular disease (CVD) is the leading and the most critical type of chronic disease. Atherosclerosis is the most common cause of CVD. Inflammation has been progressively acknowledged as a vital and central player in the pathophysiology of atherosclerosis. Baccaurea angulata is an underutilized fruit of the island of Borneo. It was obtained from Bau, Sarawak, Malaysia. In our previous studies, B. angulata did not only increase antioxidant enzyme activities, but also slowed the lipid peroxidation process in high-cholesterol-fed rabbits. It was hypothesized that B. angulata fruit would exert an anti-inflammatory effect. This study, therefore, aimed at evaluating and comparing the effects of three different B. angulata whole fruit (WF) juice doses on 11 serum inflammatory biomarkers of atherosclerosis. Methods Thirty-five male New Zealand white rabbits were divided into seven groups (n=5). Group CH was fed 1% cholesterol diet only, group C1 was fed 1% cholesterol diet and 0.5 ml/kg/day B. angulata WF juice, group C2 was fed 1% cholesterol diet and 1.0 ml/kg/day B. angulata WF juice, group C3 was fed 1% cholesterol diet and 1.5 ml/kg/day B. angulata WF juice, group N was fed standard pellet only, group N1 was fed standard pellet and 0.5 ml/kg/day B. angulata WF juice, and group N2 was fed standard pellet and 1.0 ml/kg/day B. angulata WF juice for 12 weeks. Results The administration of the various juices reduced the concentrations of induced serum inflammatory biomarkers. Conclusion This protective effect of B. angulata fruit against cardiovascular risk might be due to its polyphenol content.

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“…Island of Malaysia and several other regions of Indonesia [14]. The high antioxidant levels of B. angulata had opened a new possibility of developing it as herbal preparations that has a high potential for producing nutraceutical benefits our wellbeing.…”

Section: Fruitmentioning

confidence: 99%

Traditional and Pharmacological Reports of The Genus Baccaurea. A Review

Chowdhury¹,

Charu²,

Fatema³

et al. 2021

AJBSR

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Baccaurea is a genus of flowering plant belongs to the family Phyllanthaceae categorically large genus with members of up to 100 species and few of which have been recognized as popular healing plants in South-East Asia. (B. ramiflora), (B. angulata), (B. courtallensis), (B. macrophylla), (B. macrocarpa), (B. lanceolata), (B. racemosa) and (B. motleyana) are underutilized medicinal plants of the genus Baccaurea. The literature review revealed that Baccaurea species have been used traditionally in South-East Asian countries to treat various diseases. Baccaurea species have been believed to possess significant medicinal values like analgesic, anthelmintic, antioxidant, anti-diarrheal, antiatherosclerotic, anticancer, antidiabetic, neuropharmacological, thrombocytic, antimicrobial, etc. activities. Few species of the Baccaurea genus have demonstrated significant exposure to phytochemicals such as alkaloids, flavonoids, anthocyanins, carotenoids, tannins, phytosterols, saponins, phenolic compounds, steroids, rosmarinic acids, etc. Several bioactive constituents including 6′-O-vanilloylpicraquassioside D, 4′-O-(6-O-vanilloyl)-β-D-glucopyranosyl tachioside D, Icariside B5, picrotoximaesin, β-sitosterol, Sapidolide A, Daucosterol, methyl 2-hydroxy-3-methylbutanoate, quercetin, decanoic acid, etc. were also isolated and described from various species of Baccaurea. The purpose of this review is to evaluate the published article which is based on the medicinal values of different species of Baccaurea genus, provide updated information and knowledge on the ethnomedicinal, pharmacological and phytochemical properties and further phytochemical assessment opens a new prevalence, effectiveness in protection and clinical research.

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Baccaurea angulata fruit inhibits lipid peroxidation and induces the increase in antioxidant enzyme activities

Abstract: Our results show that B. angulata fruit is beneficial in positively influencing and managing oxidative damage.

Cited by 19 publications

References 57 publications

Lifestyle interventions for non-alcoholic fatty liver disease

Lifestyle interventions for non-alcoholic fatty liver disease

Phenolic-Rich Baccaurea angulata Modulates Inflammatory Biomarkers of Atherosclerosis

Traditional and Pharmacological Reports of The Genus Baccaurea. A Review

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