B2—Inhibitory effects of chelating drugs on lipid peroxidation in rat brain homogenates

Козлов, А. В.; Ostrachovich, E.A.; Afanas’ev, Igor B.

doi:10.1016/0891-5849(94)90223-2

Cited by 2 publications

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“…It has antioxidant and anti-inflammatory activity [7][8][9][10] and is effective in the in vitro inhibition of proliferation of human breast tumors [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of a Metal Complex Containing Naringin and Cu, and its Antioxidant, Antimicrobial, Antiinflammatory and Tumor Cell Cytotoxicity

et al. 2007

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Abstract:The antioxidant activity of flavonoids is believed to increase when they are coordinated with transition metal ions. However, the literature on this subject is contradictory and the outcome seems to largely depend on the experimental conditions. In order to understand the contribution of the metal coordination and the type of interaction between a flavonoid and the metal ion, in this study a new metal complex of Cu (II) with naringin was synthesized and characterized by FT-IR, UV-VIS, mass spectrometry (ESI-MS/MS), elemental analysis and 1 H-NMR. The results of these analyses indicate that the complex has a Cu (II) ion coordinated via positions 4 and 5 of the flavonoid. The antioxidant, anti-inflammatory and antimicrobial activities of this complex were studied and compared with the activity of free naringin. The Naringin-Cu (II) complex 1 showed higher antioxidant, anti-inflammatory and tumor cell cytoxicity activities than free naringin without reducing cell viability.

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“…It has antioxidant and anti-inflammatory activity [7][8][9][10] and is effective in the in vitro inhibition of proliferation of human breast tumors [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of a Metal Complex Containing Naringin and Cu, and its Antioxidant, Antimicrobial, Antiinflammatory and Tumor Cell Cytotoxicity

et al. 2007

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“…Диеновые конъюгаты являются маркером процессов перекисного окисления липидов, из-за наличия в них гидроперекисей полинасыщенных жирных кислот. Понижение уровня ДК является благоприятным признаком, так как ДК проявляют токсическое действие свободных радикалов и высвобождают молекулярный кислород [3].…”

Section: результаты и обсуждение/ Results and Discussionunclassified

The effect of the zinc preparation "asparzink" on the processes of lipid peroxidation and the activity of the antioxidant system of the pheasant body

Novikova

Pudovkin

Захаркина

et al. 2023

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The article presents the results of studies on the effect of the preparation "Aspartzinc" on the processes of lipid peroxidation and the activity of the antioxidant system of the pheasant organism. For the prevention of zinc deficiency conditions, various additives are often used recently. One of them is "Aspartzinc", which includes zinc aspartate. The aim of the work was to study the effect of the zinc preparation "Aspartzinc" on the processes of lipid peroxidation and the activity of the antioxidant defense system of the pheasant organism. The studies were carried out on pheasants of the North Caucasian breed. The birds were kept under the conditions of the State Budgetary Institution JSC "Directorate of the Southern Specialized Protected Areas and GOOH" Astrakhanskoye ". It has been established that the Asparzinc drug has an antioxidant effect and inhibits the processes of lipid peroxidation in the body of pheasants. It was found that after the administration of "Asparzinc" at doses of 1 mg/kg (experimental group 1) and 2 mg/kg (experimental group 2), the concentration of DC in the blood serum of pheasants decreased by 8.9% and 16.4%, respectively, relative to the initial values. The concentration of MDA in the tissues of the lungs also decreases by 14.6% (experimental group 1) and 13.5% (experimental group 2) and in the tissues of the pectoral muscle by 14.6% (dose 1 mg/kg) and 13.5% (dose 2 mg/kg), respectively, relative to the initial value.The antioxidant activity of the drug is expressed in an increase in catalase activity in the tissue of the liver, kidney and lungs after the administration of the Asparzinc preparation in birds of the 2nd experimental group, relative to the initial level. In the heart tissue after the introduction of the drug "Aspartzinc" in birds of the 1st and 2nd experimental groups, there was an increase in catalase activity by 9.8% and 14.5%, respectively, relative to the initial level.

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B2—Inhibitory effects of chelating drugs on lipid peroxidation in rat brain homogenates

Cited by 2 publications

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Synthesis and Characterization of a Metal Complex Containing Naringin and Cu, and its Antioxidant, Antimicrobial, Antiinflammatory and Tumor Cell Cytotoxicity

Synthesis and Characterization of a Metal Complex Containing Naringin and Cu, and its Antioxidant, Antimicrobial, Antiinflammatory and Tumor Cell Cytotoxicity

The effect of the zinc preparation "asparzink" on the processes of lipid peroxidation and the activity of the antioxidant system of the pheasant body

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