B16 Murine Melanoma and Aging: Slower Growth and Longer Survival in Old Mice23

Ershler, William B.; Stewart, James A.; Hacker, Miles P.; Moore, Ann L.; Tindle, Barbara H.

doi:10.1093/jnci/72.1.161

Cited by 89 publications

(46 citation statements)

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“…Immunosenescence is believed to be one possible reason for increased incidence of most types of cancer in aging humans and animals (Anisinov, 1987). There is now good clinical and experimental evidence indicating a difference in the growth rate of primary tumors and in the incidence of metastases with age (Ershler et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Influence of age, castration, and testosterone on T cell subsets in healthy and leukemia grafted mice

Aboudkhil¹,

Zaîd

Henry³

et al. 2003

Biology of the Cell

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The distribution of T cell subsets in pubertal (2 months) and post-pubertal (10 months) mice showed a significant decrease in the percentage of CD4+ splenocytes and peripheral blood lymphocytes (PBL) with age, unlike the percentage of CD8+ cells in PBL, which remained unchanged. The change in the distribution of T cell subsets in the spleen and blood occurred in 2 months old castrated mice, as in 10 months old animals. P388 tumor grew better in post-pubertal and in castrated mice than in young mice. The intact mice survived longer than the castrated ones. The relative number of CD4+, CD8+ and CD2+ splenocytes was lower in transplanted intact mice than that in controls. The CD8+ and CD2+ subsets in the blood of 2 months transplanted mice were higher than those in controls, whereas in PBL, in 10 months old and castrated mice, the T lymphocyte subsets remain unchanged. Depo-testosterone (DT) injection strongly reduced weight and tumor growth in all the intact and castrated animals. A significant correlation is observed between the tumor weight and testosterone level in the plasma of the 2 months old DT treated mice. Moreover, DT injection induced a significant increase in the percentage of blood CD8+ cells in all the batches. These data indicate that physiologically, androgens affect the age-related distribution of lymphocyte T subsets and suggest that they slow down tumor growth, besides causing a direct effect, through an immunological process.

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Section: Introductionmentioning

confidence: 99%

Influence of age, castration, and testosterone on T cell subsets in healthy and leukemia grafted mice

Aboudkhil¹,

Zaîd

Henry³

et al. 2003

Biology of the Cell

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“…It occurs commonly in normal animal tissue (embryonic growth, wound healing, local inflammatory reactions) [1,9] as well as in abnormal tissue such as seen in the growth of neoplastic tissue [10]. We have recently observed that certain weakly antigenic murine tumors (B16 melanoma and Lewis Lung carcinoma) grow more slowly in old animals when compared to young [4][5][6]. When examined histologically, one characteristic of these tumors in old animals is their relatively low number of blood vessels [16].…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte-induced angiogenesis factor is produced by L3T4+ murine T lymphocytes, and its production declines with age

Hadar

Ershler

Kreisle

et al. 1988

Cancer Immunol Immunother

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Lymphocyte-induced angiogenesis factor (LIA) is a product of T lymphocytes which has been shown to stimulate new vessel formation. Because immune senescence most profoundly affects T lymphocyte functions, we suspected that LIA production would decline with age. An assay for angiogenesis stimulated by allogeneic reaction was performed by injecting spleen cells from young or old donor mice into the skin of irradiated allogeneic recipient mice. The spleen cells from young mice induced a significantly greater number of vessels than did cells from older mice. In additional experiments, spleen cells from young and old animals were treated with a monoclonal antibody GK 1.5) directed at the L3T4 antigen on murine T helper lymphocytes. Such treatment significantly reduced the new vessel formation induced by young lymphocytes but had no effect on that induced by lymphocytes from old animals. Studies employing indirect immunofluorescence demonstrated that the proportion of L3T4+ cells in the mononuclear fraction of splenocytes was nearly identical in both young and old mice. From these investigations we can conclude that (1) L3T4+ lymphocytes are responsible for LIA production, and (2) production, like that of other T lymphokines, declines with age.

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“…But at this time, evidence from prospective randomized trials that geriatric assessment improves the care for elderly patients with cancer is still missing. [2].…”

Section: Oncology: Characteristics Of Elderly Patientsmentioning

confidence: 99%

Onkologie: Besonderheiten alter Menschen

Wedding¹,

Höffken²

2003

Visc Med

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Oncology: Characteristics of Elderly Patients The number of elderly patients with cancer will increase substantially within the next decades. These patients are not treated with the same oncological diligence as younger patients. Older patients are less often treated within clinical trials. The available data represent a selected group of patients. Older patients present with a variety of changes, which have to be taken into consideration for decision making. These are 1) reduced live expectation, 2) reduced reserve capacity, 3) changes in pharmacokinetics and pharmacodynamics, 4) co-morbidities, 5) co-medication, and 6) restrictions in functional status. In addition to a thorough examination of the oncological disease, the special situation of the elderly patients should be assessed within a geriatric assessment. It often reflects the true situation of the patients better than the normal clinical examination. This kind of assessment will be important within different decision processes: 1) early detection, 2) need of surgery, 3) need of adjuvant therapy, 4) intensity of chemotherapy, and 5) kind of follow-up. But at this time, evidence from prospective randomized trials that geriatric assessment improves the care for elderly patients with cancer is still missing.

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B16 Murine Melanoma and Aging: Slower Growth and Longer Survival in Old Mice23

Cited by 89 publications

References 0 publications

Influence of age, castration, and testosterone on T cell subsets in healthy and leukemia grafted mice

Influence of age, castration, and testosterone on T cell subsets in healthy and leukemia grafted mice

Lymphocyte-induced angiogenesis factor is produced by L3T4+ murine T lymphocytes, and its production declines with age

Onkologie: Besonderheiten alter Menschen

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