Influence of age, castration, and testosterone on T cell subsets in healthy and leukemia grafted mice

Aboudkhil, Souad; Zaîd, Abdelhamid; Henry, Laurent; Bureau, Jean Paul

doi:10.1016/s0248-4900(02)01221-2

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…In agreement with some previous findings [39,40], in control rats the count of CD4+ decreased with aging, whereas that of CD8+ cells did not significantly change. Consequently, the CD4+:CD8+ PBL ratio was lower in aged rats than in young rats.…”

Section: Discussionsupporting

confidence: 93%

Androgens Contribute to Age-Associated Changes in Peripheral T-Cell Homeostasis Acting in a Thymus-Independent Way

Arsenović-Ranin¹,

Kosec

Pilipović

et al. 2014

Neuroimmunomodulation

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Objective: Considering a causal role of androgens in thymic involution, age-related remodeling of peripheral T-cell compartments in the absence of testicular hormones was evaluated. Methods: Rats were orchidectomized (ORX) at the age of 1 month, and T-peripheral blood lymphocytes (PBLs) and splenocytes from young (75-day-old) and aged (24-month-old) rats were examined for differentiation/activation and immunoregulatory marker expression. Results: In ORX rats, following the initial rise, the counts of CD4+ and CD8+ PBLs diminished with aging. This reflected the decline in thymic export as shown by recent thymic emigrant (RTE) enumeration. Orchidectomy increased the count of both of the major T-splenocyte subsets in young rats, and they (differently from controls) remained stable with aging. The CD4+:CD8+ T-splenocyte ratio in ORX rats shifted towards CD4+ cells compared to age-matched controls. Although in the major T-cell subsets in the blood and spleen from aged ORX rats the numbers of RTEs were comparable to the corresponding values in age-matched controls, the numbers of mature naïve and memory/activated cells substantially differed. Compared with age-matched controls, in aged ORX rats the numbers of CD4+ mature naïve PBLs and splenocytes were reduced, whereas those of CD4+ memory/activated cells (predictive of early mortality) were increased. Additionally, in spleens from aged ORX rats, despite unaltered thymic export, CD4+CD25+FoxP3+ and natural killer T cell counts were greater than in age-matched controls. Conclusion: (i) Age-related decline in thymopoietic efficacy is not dependent on androgen presence, and (ii) androgens are involved in the maintenance of peripheral T-cell (particularly CD4+ cell) homeostasis during aging.

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Section: Discussionsupporting

confidence: 93%

Androgens Contribute to Age-Associated Changes in Peripheral T-Cell Homeostasis Acting in a Thymus-Independent Way

Arsenović-Ranin¹,

Kosec

Pilipović

et al. 2014

Neuroimmunomodulation

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“…Furthermore, while restoration of the gonadal axis in the long-term after renal transplantation may be important for virility and fertility, hypogonadism could be a potential contributor to the immense loss of bone mass observed in the early period after renal transplantation although testosterone therapy starting in the early period after transplantation was not successful to prevent bone loss in patients with allogeneic stem cell transplantation [8, 9]. In addition, it is of interest that testosterone has an activating effect on T cells in animal models [10] potentially leading to enhanced damage of renal transplants [11]. Thereby, testosterone could potentially influence the rejection process early after renal transplantation.…”

Section: Introductionmentioning

confidence: 99%

Free Androgen Index Is Superior to Total Testosterone for Short-Term Assessment of the Gonadal Axis after Renal Transplantation

et al. 2005

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Objective: Recent studies have assessed gonadal function in association with different immunosuppressive drugs in transplanted patients mainly relying on the measurement of total testosterone. It is the aim of this study to assess the short-term changes of the hypothalamic-pituitary-gonadal axis following renal transplantation using the free androgen index (FAI). Patients and Methods: The sequential changes in total testosterone, sex hormone-binding globulin (SHBG), gonadotropin and prolactin concentrations were measured in 22 male patients before and after 1–3 days, and 1, 2 and 3 weeks following renal transplantation. Results: Total testosterone and SHBG concentrations dropped significantly after transplantation (total testosterone: baseline: 15.2 ± 1.6 nmol/l vs. 1 week: 7.9 ± 0.8 nmol/l vs. 2 weeks: 9.8 ± 0.9 nmol/l, SHBG: baseline: 29.9 ± 3.2 nmol/l vs. 1 week: 19.9 ± 2.1 nmol/l, 2 weeks: 18.9 ± 2.4 nmol/l, p < 0.01). FAI decreased significantly after day 1–3 returning to values near baseline thereafter (baseline: 60 ± 9% vs. day 1–3: 38 ± 6%, 2 weeks: 61 ± 7%; p < 0.01). There was a significant positive correlation between FAI and renal function. Conclusion: Measurement of the free androgen index is superior to total testosterone for assessment of the pituitary-gonadal axis in the first weeks after renal transplantation.

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Influence of Gestational Hormones on the Bacteria-Induced Cytokine Response in Periodontitis

Ortiz-Sánchez

Legorreta-Herrera²,

Rodrı́guez-Sosa³

2021

Mediators of Inflammation

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Periodontitis is an inflammatory disease that affects the supporting structures of teeth. The presence of a bacterial biofilm initiates a destructive inflammatory process orchestrated by various inflammatory mediators, most notably proinflammatory cytokines, which are upregulated in the gingival crevicular fluid, leading to the formation of periodontal pockets. This represents a well-characterized microbial change during the transition from periodontal health to periodontitis; interestingly, the gestational condition increases the risk and severity of periodontal disease. Although the influence of periodontitis on pregnancy has been extensively reviewed, the relationship between pregnancy and the development/evolution of periodontitis has been little studied compared to the effect of periodontitis on adverse pregnancy outcomes. This review is aimed at summarizing the findings on the pregnancy-proinflammatory cytokine relationship and discussing its possible involvement in the development of periodontitis. We address (1) an overview of periodontal disease, (2) the immune response and possible involvement of proinflammatory cytokines in the development of periodontitis, (3) how bone tissue remodelling takes place with an emphasis on the involvement of the inflammatory response and metalloproteinases during periodontitis, and (4) the influence of hormonal profile during pregnancy on the development of periodontitis. Finally, we believe this review may be helpful for designing immunotherapies based on the stage of pregnancy to control the severity and pathology of periodontal disease.

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Influence of age, castration, and testosterone on T cell subsets in healthy and leukemia grafted mice

Cited by 5 publications

References 29 publications

Androgens Contribute to Age-Associated Changes in Peripheral T-Cell Homeostasis Acting in a Thymus-Independent Way

Androgens Contribute to Age-Associated Changes in Peripheral T-Cell Homeostasis Acting in a Thymus-Independent Way

Free Androgen Index Is Superior to Total Testosterone for Short-Term Assessment of the Gonadal Axis after Renal Transplantation

Influence of Gestational Hormones on the Bacteria-Induced Cytokine Response in Periodontitis

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