B Vitamins and Their Roles in Gut Health

Hossain, Khandkar Shaharina; Amarasena, Sathya; Mayengbam, Shyamchand

doi:10.3390/microorganisms10061168

Cited by 43 publications

(31 citation statements)

References 131 publications

(175 reference statements)

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“…Vitamin B5producing bacteria include E. coli and Salmonella typhimurium. Escherichia coli can utilize aspartate and intermediate metabolites of valine biosynthesis as substrate (24,(105)(106)(107). Salmonella typhimurium produces pantothenate from alpha-ketoisovalerate using acetohydroxy acid synthase isozyme I and dihydroxy acid dehydratase enzymes (108).…”

Section: Influence Of Gut Microbiota On Vitamin B5 Utilizationmentioning

confidence: 99%

“…It has long been recognized that the normal microbiota of large intestine can synthesize large amounts of biotin. Vitamin B7-producing microbiota includes B. fragilis , F. varium , and Campylobacter coli ( 24 ). Meanwhile, vitamin B7-consuming bacteria must gain vitamin B7 from the environment to maintain microbial functions and these bacteria lack the vitamin B7 biosynthetic pathways.…”

Section: Vitamin B7mentioning

confidence: 99%

“…The potential interaction between vitamin B and gut microbiota has raised the interest to study the relationship between vitamin B and gut microbiota. Recently, excellent review papers have been published to reveal the role of vitamin B on gut microbiota, how gut microbiota affect the absorption of vitamin B remains unclear ( 24 , 25 ). To establish the relationship between vitamin B and gut microbiota, it is required to understand not only the role of gut microbiota on vitamin B absorption, but also the influence of gut microbiota on vitamin B absorption.…”

Section: Introductionmentioning

confidence: 99%

“…24,105,106) L. helveticus, Streptococcus and E. faecalis, members of the vitamin B5 non-producing. Firmicutes phylum, requires vitamin B5 for their growth in vitro(109,110,235).…”

mentioning

confidence: 99%

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Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Wan

Zheng²,

Zhu³

et al. 2022

Front. Nutr.

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Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As an integrated part of human health, gut microbiota could produce, consume, and even compete for vitamin B with the host. The interplay between gut microbiota and the host might be a crucial factor affecting the absorbing processes of vitamin B. On the other hand, vitamin B supplementation or deficiency might impact the growth of specific bacteria, resulting in changes in the composition and function of gut microbiota. Together, the interplay between vitamin B and gut microbiota might systemically contribute to human health. In this review, we summarized the interactions between vitamin B and gut microbiota and tried to reveal the underlying mechanism so that we can have a better understanding of its role in human health.

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Section: Influence Of Gut Microbiota On Vitamin B5 Utilizationmentioning

confidence: 99%

Section: Vitamin B7mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…24,105,106) L. helveticus, Streptococcus and E. faecalis, members of the vitamin B5 non-producing. Firmicutes phylum, requires vitamin B5 for their growth in vitro(109,110,235).…”

mentioning

confidence: 99%

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Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Wan

Zheng²,

Zhu³

et al. 2022

Front. Nutr.

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“…B-vitamins are essential micronutrients for humans and for the majority of microbes ( 3 ), and are associated with enzymatic activity as co-factors for numerous cellular reactions involving energy production, neurotransmitter synthesis, immune functions, and one-carbon metabolism ( 4 ). Vitamin B12 (cobalamin; referred here as B12), the precursor of the B12 coenzyme family, is a class of water-soluble molecules with a complex organometallic structure containing a corrin ring bound to a central cobalt atom, to which upper and lower ligands are attached ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Healthy adult gut microbiota sustains its own vitamin B12 requirement in an in vitro batch fermentation model

et al. 2022

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Vitamin B12 (cobalamin) is present in the human lower gastrointestinal tract either coming from the unabsorbed dietary fraction or from in situ production of the gut microbiota. However, it is unclear whether the gut microbial communities need exogenous B12 for growth and metabolism, or whether B12 in low and high levels could affect gut community composition and metabolite production. Here, we investigated in vitro B12 production of human fecal microbiota and the effects of different levels of B12 (as cyanocobalamin) on composition and activity. Eight fecal communities from healthy human adults distributed over three enterotypes, dominated by Firmicutes (n = 5), Bacteroides (n = 1) or Prevotella (n = 2) were used to perform batch fermentations in Macfarlane medium supplemented with low B12 medium (Control, 5 ng/ml, within the tested fecal range), no B12 addition (NB12), and high B12 addition (ExtraB12, 2500 ng/ml). The microbiota community composition (qPCR, 16S rRNA metabarcoding), metabolic activity (HPLC-RI), and B12 levels (UHPLC-DAD) were measured after 24 h incubation at 37°C under strict anaerobic conditions. All fecal microbial communities produced B12 in the NB12 condition after 24 h, in the range from 152 ± 4 to 564 ± 25 ng/ml. None of the B12 treatments had an impact on total bacterial growth, community richness, diversity and total metabolite production, compared to the low B12 control. However, a significant increase of propionate was measured in ExtraB12 compared to NB12. Most taxonomic and metabolite changes compared to control incubations were donor-dependent, implying donor-microbiota-specific changes upon B12 treatments. Our in vitro data suggest that healthy human adult gut microbial communities have the capacity to produce B12 at levels fulfilling their own requirements, independently of the initial B12 content tested in the donor’s feces. Further, supplementation of exogenous dietary B12 may have limited impact on the healthy human gut microbial community composition and function.

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The effects of the interplay between vitamins, antibiotics, and gut microbiota on the pathogenesis and progression of dementia: A systematic review and meta‐analysis

Prajjwal,

Inban,

Sai

et al. 2024

Health Science Reports

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BackgroundGiven that there is already evidence of a neural network that connects the brain and gut and that the gut microbiota actively modulates gut health, it is crucial to know which foods, supplements, and medications to use or avoid when treating any disease that causes dementia or cognitive impairment. Previous research has examined the relationships between vitamins, antibiotics, and gut microbiota and the correlations between these factors and dementia. The question arises of how these three factors interact together and if evidence suggests one element is more important than the others in the pathogenesis and development of dementia.MethodsThe Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) standards were followed when conducting this review. The papers' publication dates varied from (2012−2022). Cochrane/EMBASE, PEDro, and PubMed/Medline databases were searched. The precise terms “gut microbiota,” vitamins,” antibiotics,” and “dementia” were included in the search method, along with the conjunctions “OR” and “AND.”ResultsGut dysbiosis has a significant impact on cognition, brain function, and the development and progression of dementia. The two most popular probiotics used in studies linked to cognition benefits were Lactobacillus and Bifidobacterium. Numerous scales were used to evaluate cognition, but the mini‐mental state examination was the most popular, and the most prevalent impairment was Alzheimer's disease. The supplements with the most significant impact on gut microbiota were vitamin B‐12 and folic acid.ConclusionThis systematic review concluded that vitamins, gut microbiota and antibiotics have a close association with the development of dementia. More research is required to establish causality and elucidate the underlying mechanisms because there is still little evidence connecting the interactions of vitamins, medications, and microbiota with dementia. The complexity of interactions between genetics, lifestyle factors, and comorbidities, as well as the heterogeneity of dementia, may make it more challenging to interpret the findings.

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B Vitamins and Their Roles in Gut Health

Cited by 43 publications

References 131 publications

Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Healthy adult gut microbiota sustains its own vitamin B12 requirement in an in vitro batch fermentation model

The effects of the interplay between vitamins, antibiotics, and gut microbiota on the pathogenesis and progression of dementia: A systematic review and meta‐analysis

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