B-type natriuretic peptide response and reverse left ventricular remodeling after surgical correction of functional mitral regurgitation in patients with advanced cardiomyopathy

Kainuma, Satoshi; Taniguchi, Koichi; Toda, Köichi; Shudo, Yasuhiro; Takeda, Koji; Funatsu, Toshihiro; Miyagawa, Shigeru; Kondoh, Haruhiko; Nishi, Hiroyuki; Yoshikawa, Yasushi; Fukushima, Satsuki; Hamada, Seiki; Kubo, Kōji; Daimon, Takashi; Sawa, Yoshiki

doi:10.1016/j.jjcc.2015.02.015

Cited by 18 publications

(14 citation statements)

References 31 publications

(47 reference statements)

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“…However, as for MV annuloplasty, which provides symptomatic improvement without proven impact on mortality [25][26][27], a randomized prospective trial is necessary for definitive proof. Due to the spreading use of MC therapy such studies are difficult to implement.…”

Section: Discussionmentioning

confidence: 99%

Long-term survival after MitraClip ® therapy in patients with severe mitral regurgitation and severe congestive heart failure: A comparison among survivals predicted by heart failure models

Schau

Isotani

Neuß

et al. 2016

Journal of Cardiology

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In the overall patient cohort defined by 3+ to 4+ mitral valve regurgitation with New York Heart Association III and IV symptomatic heart failure, mortality following MC is consistent with that predicted by SHFM and MAGGIC for patients that are not at high risk. However, the subset of patients with severe heart failure defined by NTproBNP >10,000pg/ml had worse than predicted mortality and may not benefit from MC therapy, mainly due to a high 30-day mortality.

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Section: Discussionmentioning

confidence: 99%

Long-term survival after MitraClip ® therapy in patients with severe mitral regurgitation and severe congestive heart failure: A comparison among survivals predicted by heart failure models

Schau

Isotani

Neuß

et al. 2016

Journal of Cardiology

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“…This outcome may be attributable to the phenomenon known as LV reverse remodeling (LV-RR), which is characterized by an increase in the pump function and a decrease in the LV dimension [7]. LV-RR predicts heart failure staging, exercise performance, and independently, the long-term prognosis of patients with idiopathic DCM [8][9][10][11][12]. Therefore, the predicted LV-RR could be used to stratify patients with latent myocardial damage.…”

Section: Introductionmentioning

confidence: 99%

Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy

Morimoto

Okumura

Hirashiki

et al. 2017

Journal of Cardiology

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“…(24) Several other markers of adverse LV remodelling have been studied in patients with valvular heart disease and heart failure in including ST2, cytokines, markers of apoptosis (FAS and FAS ligand) and the MMPs and their inhibitors. (25)(26)(27)(28)(29)(30)(31)(32) Here we have shown that there is a poor correlation between the tissue gene expression levels of several of these markers of adverse LV remodelling in patients with CPMR and the serum levels of these markers sampled at the same time.…”

Section: Discussionmentioning

confidence: 75%

Correlation between Serum Markers of Adverse Left Ventricular Remodelling and Gene Expression Levels Measured in the Myocardial Tissue of Patients with Chronic Primary Mitral Regurgitation

McCutcheon¹,

Dickens²,

Pelt³

et al. 2020

Wits Journal of Clinical Medicine

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Telephone number: +32 (0)16 34 15 33, Fax number: +32 (0) 16 32 15 13, keir.mccutcheon@uzleuven.be ABSTRACT Background: Chronic primary mitral regurgitation (CPMR) is characterized by progressive myocardial hypertrophy, fibrosis and dilatation. Although molecular markers of adverse left ventricular (LV) remodelling have been identified in the progression from compensated to decompensated heart failure in these patients, serum markers that could guide the optimal timing of intervention in these patients are still needed. Here we describe the correlation between the levels of expression of several genes important in adverse LV remodelling in CPMR and the serum levels of these markers. Methods:We performed echocardiography, cardiac catheterization, endomyocardial biopsy (EMB) and serum analysis in patients with severe CPMR during the preoperative workup for mitral valve surgery. Serum levels of N-terminal-pro hormone B-type natriuretic peptide, suppression of tumourigenicity 2, tumour necrosis factor a, Interleukin 6, FS-7-associated surface antigen (FAS), FAS ligand, matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinases (TIMP)-1 and TIMP-4 were determined using commercially available enzyme-linked immunosorbent assays. Myocardial levels of expression of the genes encoding these proteins were determined by multiplex gene expression analysis.Results: Serum and EMBs were obtained from 12 patients with CPMR at the time of preoperative cardiac catheterization. Overall, there was no significant correlation between the serum levels and gene expression levels for the markers evaluated in this study. A non-significant inverse correlation between serum MMP-2 and myocardial MMP-2 was noted (r = −0.343, P = 0.263). Conclusion:We found a poor correlation between the myocardial gene expression levels of several markers of adverse LV remodelling in patients with CPMR and the serum levels of these markers sampled at the same time.

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B-type natriuretic peptide response and reverse left ventricular remodeling after surgical correction of functional mitral regurgitation in patients with advanced cardiomyopathy

Cited by 18 publications

References 31 publications

Long-term survival after MitraClip ® therapy in patients with severe mitral regurgitation and severe congestive heart failure: A comparison among survivals predicted by heart failure models

Long-term survival after MitraClip ® therapy in patients with severe mitral regurgitation and severe congestive heart failure: A comparison among survivals predicted by heart failure models

Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy

Correlation between Serum Markers of Adverse Left Ventricular Remodelling and Gene Expression Levels Measured in the Myocardial Tissue of Patients with Chronic Primary Mitral Regurgitation

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