B-type natriuretic peptide in reversible myocardial ischaemia: Table 1

Abstract

Background: Coronary heart disease is associated with increased B-type natriuretic peptides (BNPs), and, although controversial, may cause exaggerated exercise-induced BNP secretion. We investigated BNP in relation to reversible myocardial ischaemia. Materials and methods: Serum N-terminal proBNP (NTproBNP) was measured before and after an exercise electrocardiogram test (ETT) in 14 patients with and 45 patients without exercise-induced myocardial ischaemia. Statistical analysis was carried out on logarithmically transformed data. Results, however, are pre-transformed data.Results: NT-proBNP increased with exercise both in ETTpositive patients (mean (SD) 71.4 (41.2) v 76.8 (44.0) ng/l; p,0.001) and ETT-negative patients (54.0 (61.2) v 60.1 (69.0) ng/l; p,0.001). Pre-exercise and post-exercise NTproBNP were higher (p,0.05) in ETT-positive than in ETTnegative patients. Incremental NT-proBNP was similar in ETTpositive (4.7 (4.2) ng/l) and ETT-negative (6.2 (8.6) ng/l) patients. Conclusion: Serum NT-proBNP concentrations are higher in patients with exercise-induced myocardial ischaemia than in those without. Exercise-induced electrocardiographic myocardial ischaemia, however, is not associated with exaggerated BNP secretion.

Serum high-sensitivity C-reactive protein, amyloid-associated protein and N-terminal proBNP levels do not predict reversible myocardial ischaemia

“…also reported similar results 32,33. On the other hand, other studies reported contradictory findings 34,35. In a study, before and after exercise testing, serum NT-proBNP levels were studied hourly for six hours and NT-proBNP levels were not found to be correlated with myocardial ischaemia 36…”

NT-proBNP for Pulmonologists: Not Only a Rule-Out Test for Systolic Heart Failure but Also a Global Marker of Heart Disease

“…Wang et al [8] also observed a strong association between atrial fibrillation and NT-proBNP. As to the effect of myocardial ischemia, our findings are difficult to compare with other studies, because dyspnea rather than angina or a positive exercise test was the criterion for entry [27]. The response of NT-proBNP secretion to ischemic episodes causing dyspnea may differ from the response to ischemia presenting as angina pectoris [28].…”

Seemingly healthy 71‐year‐old men with minor elevations of cardiac troponin I and at risk of premature death in CVD have elevated levels of NT‐proBNP: Report from the ULSAM study

“…in patients with the acute coronary syndrome, NT-proBNP is also found elevated and correlated to the concentrations of cardiac troponins [15,16]. It has been shown that myocardial ischaemia augments synthesis and release of natriuretic peptides and that hypoxia upregulates the BNPgene [17][18][19][20]. In the PEACE study on patients with low-risk stable coronary disease it was concluded that BNPs provide strong and incremental prognostic information to traditional risk factors [21].…”