Serum high-sensitivity C-reactive protein, amyloid-associated protein and N-terminal proBNP levels do not predict reversible myocardial ischaemia

Başkurt, Murat; Aktürk, Faruk; Keskin, Kudret; Canbolat, Polat; Karadağ, Bilgehan; Kaya, Ayşem; Yıldız, Ahmet; Coşkun, Ünsal; Kılıçkesmez, Kadriye Orta; Esen, Özlem; Muniboglu, S.K.

doi:10.5830/cvja-2010-041

Cited by 5 publications

(7 citation statements)

References 38 publications

(35 reference statements)

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“…Serum total IgE was analyzed on nephelometry (Siemens Healthcare Diagnostics, Deerfield, Germany), and high was defined as >2 SD according to age. hs‐CRP (as mg/dL) was measured using a BN II device (Dade Behring BN Pro Spec, Marburg, Germany) on nephelometry …”

Section: Methodsmentioning

confidence: 99%

Importance of high sensitivity C‐reactive protein in the evaluation of wheezing in children

Bostancı

Özmen

Şen

et al. 2016

Pediatrics International

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Background It is important to determine the presence of asthma in children under the age of 3 with recurrent wheezing. Inflammatory markers have been investigated in the diagnosis and treatment of asthma. The aim of the present study was to investigate the relationship between recurrent wheezing with or without modified asthma predictive index (mAPI) positivity and high‐sensitivity‐C reactive protein (hs‐CRP) level in children aged 6–36 months. Methods Ninety‐nine children with recurrent wheezing and 47 healthy children aged 6–36 months were included in the present cross‐sectional, case–control study. Those children with wheezing were divided into two groups according to mAPI positivity. Results Mean serum hs‐CRP was higher in the recurrent wheezers than in the control group (0.89 ± 1.7 mg/dL vs 0.12 ± 1.3 mg/dL, respectively; P = 0.002). There was a positive correlation between serum total IgE and hs‐CRP (P = 0,003; r = 0348). mAPI positivity was detected in 46 of the recurrent wheezers (46.5%). There was no significant difference in hs‐CRP between the mAPI‐positive and ‐negative groups. The best hs‐CRP cut‐off for differentiating between the patient and control groups was 0.11 mg/dL on receiver operating characteristic analysis (area under curve, 0.658; 95%CI: 0.571–0.744; P < 0.05; sensitivity, 60%; specificity, 61.7%). Conclusions High‐sensitivity CRP can be used to indicate respiratory and systemic inflammation independently of mAPI positivity in wheezy children.

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Section: Methodsmentioning

confidence: 99%

Importance of high sensitivity C‐reactive protein in the evaluation of wheezing in children

Bostancı

Özmen

Şen

et al. 2016

Pediatrics International

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“…The remaining 11 studies did not address whether the reference standard results were blinded and five of those studies also did not mention if the index test results were blinded. [19,11,20,10,7,6,9,5,13,8,15,14,12,4,21]…”

Section: Risk Of Biasmentioning

confidence: 99%

“…BNP [4][5][6]; ProBNP [19,21,20] BNP: B-type natriuretic peptide; ProBNP: pro-B-type natriuretic peptide…”

Section: Figure 3: Meta-analysis Of Studies Reporting Mean Valuesmentioning

confidence: 99%

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Stress-delta B-type Natriuretic Peptide Levels as a Test for Inducible Myocardial Ischemia: A Systematic Review and Meta-Analysis

Kheang

Rodrigues

Vissoci

et al. 2020

Cureus

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“…Prior research suggests that myocardial ischaemia induced by stress testing is associated with dynamic increases (stress-deltas) in N-terminal pro-B type natriuretic peptide (NT-proBNP) concentrations 22–29. These studies only included outpatients with symptoms of stable angina.…”

Section: Introductionmentioning

confidence: 99%

Provocative biomarker stress test: stress-delta N-terminal pro-B type natriuretic peptide

et al. 2018

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ObjectiveStress testing is commonly performed in emergency department (ED) patients with suspected acute coronary syndrome (ACS). We hypothesised that changes in N-terminal pro-B type natriuretic peptide (NT-proBNP) concentrations from baseline to post-stress testing (stress-delta values) differentiate patients with ischaemic stress tests from controls.MethodsWe prospectively enrolled 320 adult patients with suspected ACS in an ED-based observation unit who were undergoing exercise stress echocardiography. We measured plasma NT-proBNP concentrations at baseline and at 2 and 4 hours post-stress and compared stress-delta NT-proBNP between patients with abnormal stress tests versus controls using non-parametric statistics (Wilcoxon test) due to skew. We calculated the diagnostic test characteristics of stress-delta NT-proBNP for myocardial ischaemia on imaging.ResultsAmong 320 participants, the median age was 51 (IQR 44–59) years, 147 (45.9%) were men, and 122 (38.1%) were African–American. Twenty-six (8.1%) had myocardial ischaemia. Static and stress-deltas NT-proBNP differed at all time points between groups. The median stress-deltas at 2 hours were 10.4 (IQR 6.0–51.7) ng/L vs 1.7 (IQR −0.4 to 8.7) ng/L, and at 4 hours were 14.8 (IQR 5.0–22.3) ng/L vs 1.0 (−2.0 to 10.3) ng/L for patients with ischaemia versus those without. Areas under the receiver operating curves were 0.716 and 0.719 for 2-hour and 4-hour stress-deltas, respectively. After adjusting for baseline NT-proBNP levels, the 4-hour stress-delta NT-proBNP remained significantly different between the groups (p=0.009).ConclusionAmong patients with ischaemic stress tests, static and 4-hour stress-delta NT-proBNP values were significantly higher. Further study is needed to determine if stress-delta NT-proBNP is a useful adjunct to stress testing.

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Serum high-sensitivity C-reactive protein, amyloid-associated protein and N-terminal proBNP levels do not predict reversible myocardial ischaemia

Cited by 5 publications

References 38 publications

Importance of high sensitivity C‐reactive protein in the evaluation of wheezing in children

Importance of high sensitivity C‐reactive protein in the evaluation of wheezing in children

Stress-delta B-type Natriuretic Peptide Levels as a Test for Inducible Myocardial Ischemia: A Systematic Review and Meta-Analysis

Provocative biomarker stress test: stress-delta N-terminal pro-B type natriuretic peptide

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