B-type natriuretic peptide and acute heart failure: Fluid homeostasis, biomarker and therapeutics

Torres-Courchoud, I.; Chen, H.H.

doi:10.1016/j.rce.2016.01.009

Cited by 9 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NPPB expression on hypertrophic hiPS-CMs was inhibited by DH at 2.5 and 5.0 μL/mL compared with that of ET-1 group ( P < 0.01) (Figure 3A ). BNP measurement has become a mainstay for HF diagnosis and monitoring worldwide [ 14 ]. Thus, HCA was adopted for the evaluation of BNP content (Figure 3B ).…”

Section: Resultsmentioning

confidence: 99%

DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy

Zhang

Guo

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Cardiac hypertrophy (CH) is an independent risk factor for cardiovascular diseases (CVDs). Mitigating or preventing CH is the most effective strategy for the treatment of CVDs. DanHong injection (DH) is a Chinese herbal medicine preparation (CHMP) widely used in clinical treatment of several CVDs in China. However, the direct targets and cellular mechanisms for these protective effects remain unclear. This study was designed to illustrate the direct targets of DH in protecting against CH and investigate CH molecular pathogenesis. A hypertrophic cell model was induced by endothelin-1 (ET-1) on human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Real time cellular analysis (RTCA) cardio system and high content analysis (HCA) were used to detect the changes in contractile function, morphology and protein level of hypertrophic hiPS-CMs. Agonist and antagonist assay on receptors were performed using calcium mobilization high-throughput screening (HTS). DH significantly attenuated CH by modulating myocardial contractility, suppressing cell area enlargement and down-regulating ET-1-induced brain natriuretic peptide (BNP), actinin alpha 2 (ACTN2) and cardiac muscle troponin T (TNNT2) protein expression (P < 0.05). Endothelin receptor type B (ETBR) and angiotensin II receptor type 1 (AT1R) were DH direct targets, with IC50 value of 25.67 μL/mL and 1.10 μL/mL, respectively. Proteomics analysis showed that proteins involved in cell cycle inhibition, RNA processing, mitochondrial translation and cytoskeleton are significant regulated by DH treatment. These data revealed that ETBR and AT1R are DH direct targets on protecting against CH, providing a strategy to explore direct targets of CHMPs.

show abstract

Section: Resultsmentioning

confidence: 99%

DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy

Zhang

Guo

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Plasma levels of NPs are crucial in the evaluation of patients with HF (146,148). Elevated serum levels of brain natriuretic peptide (BNP) are independently associated with poorer outcomes (149,150) and predict higher in-hospital mortality in very elderly patients admitted for HF (151).…”

Section: Neurohormonal Factorsmentioning

confidence: 99%

Role of circulating factors in cardiac aging

Cannatà¹,

Marcon²,

Cimmino³

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

Worldwide increase in life expectancy is a major contributor to the epidemic of chronic degenerative diseases. Aging, indeed, simultaneously affects multiple organ systems, and it has been hypothesized that systemic alterations in regulators of tissue physiology may regulate this process. Cardiac aging itself is a major risk factor for cardiovascular diseases and, because of the intimate relationship with the brain, may contribute to increase the risk of neurodegenerative disorders. Blood-borne factors may play a major role in this complex and still elusive process. A number of studies, mainly based on the revival of parabiosis, a surgical technique very popular during the 70s of the 20 th century to study the effect of a shared circulation in two animals, have indeed shown the potential that humoral factors can control the aging process in different tissues. In this article we review the role of circulating factors in cardiovascular aging. A better understanding of these mechanisms may provide new insights in the aging process and provide novel therapeutic opportunities for chronic age-related disorders.

show abstract

Localization profiles of natriuretic peptides in hearts of pre-hibernating and hibernating Anatolian ground squirrels (Spermophilus xanthoprymnus)

et al. 2019

View full text Add to dashboard Cite

B-type natriuretic peptide and acute heart failure: Fluid homeostasis, biomarker and therapeutics

Cited by 9 publications

References 30 publications

DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy

DanHong injection targets endothelin receptor type B and angiotensin II receptor type 1 in protection against cardiac hypertrophy

Role of circulating factors in cardiac aging

Localization profiles of natriuretic peptides in hearts of pre-hibernating and hibernating Anatolian ground squirrels (Spermophilus xanthoprymnus)

Contact Info

Product

Resources

About