2003
DOI: 10.2214/ajr.181.5.1811197
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Pulsed Tunable Monochromatic X-Ray Beams from a Compact Source: New Opportunities

Abstract: 1197he science of X-ray production and application is now a little more than a century old [1] but is still an active field of research and development [2].Historically, X rays for imaging and crystallography have generally been produced through the use of bremsstrahlung and line X rays from electrons impinging on a metallic anode. Such sources are inexpensive, simple, and robust but provide little control over the X rays produced. More recently, synchrotron sources have been used for both applications, with g… Show more

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Cited by 81 publications
(29 citation statements)
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“…An important step toward the clinical implementation of this method is the requirement of compact Xray sources that enable to deliver quasi monochromatic X-rays with flux densities between those available at the large scale synchrotron radiation and at the clinical X-ray generators. Fortunately, such compact X-ray sources are currently under rapid development worldwide, including compact synchrotron radiation (36,37), tabletop high harmonic generation (38), Compton backscattering systems (39), and liquid-metal-jet-anode microfocus sources (40). Finally, although we used a human breast cancer sample as proof of principle in this study, this method can in principle be applied to other medical tomography fields where high resolution, high contrast, low radiation doses and fast data acquisition are crucially needed.…”
Section: Discussionmentioning
confidence: 99%
“…An important step toward the clinical implementation of this method is the requirement of compact Xray sources that enable to deliver quasi monochromatic X-rays with flux densities between those available at the large scale synchrotron radiation and at the clinical X-ray generators. Fortunately, such compact X-ray sources are currently under rapid development worldwide, including compact synchrotron radiation (36,37), tabletop high harmonic generation (38), Compton backscattering systems (39), and liquid-metal-jet-anode microfocus sources (40). Finally, although we used a human breast cancer sample as proof of principle in this study, this method can in principle be applied to other medical tomography fields where high resolution, high contrast, low radiation doses and fast data acquisition are crucially needed.…”
Section: Discussionmentioning
confidence: 99%
“…Regardless of viewpoint, the end result is the potential to generate hard x-rays using optical wavelength light and 0.1 GeV-range electron beams. X-ray ICS sources have been proposed and demonstrated over the past decade [6,7,8] and they produce photons with energies of tens of keV. Estimates for the peak brightness of these sources are on the order of 10 20 − 10 22 ph/mm 2 /mrad 2 /s/0.1%BW, more than 10 orders of magnitude below the estimate for hard x-ray free electron lasers (FELs).…”
Section: Introductionmentioning
confidence: 99%
“…With smaller energies demanded, an ICS instrument is potentially very compact in size, permitting x-ray light source research facilities in small university-scale laboratories [4]. Emerging applications in medicine [5,6] that can benefit from nearly monochromatic hard (∼10-100 keV) x-rays are found in both diagnosise.g. in phase contrast or dual-energy digital subtraction imaging-and therapy, where K-edge absorption may be used to greatly enhance local x-ray dose (e.g.…”
Section: Introductionmentioning
confidence: 99%