<b>Multidetector CT:</b> Diagnostic Impact of Slice Thickness on Detection of Hypervascular Hepatocellular Carcinoma

Kawata, Shigeto; Murakami, Takamichi; Kim, Tonsok; Hori, Masatoshi; Federle, Michael P.; Kumano, Seishi; Sugihara, Eiji; Makino, Seiya; Nakamura, Hajime; Kudo, Masayuki

doi:10.2214/ajr.179.1.1790061

Cited by 81 publications

(38 citation statements)

References 21 publications

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“…The sensitivity for HCC detection in plasma miR-224 was 78.7-90.7% (Table 2). This result indicates that the sensitivity of plasma miR-224 was not inferior to that of recent imaging modalities such as ultrasonography, computed tomography (CT), gadolinium ethoxybenzyl diethlenetriamine pentaacetic acid-enhanced liver magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI), their sensitivities were 60.5%, 76.0% and 88.5%, respectively [81][82][83]. Moreover, plasma miR-224 may be an indicator of residual tumor in non-surgical treatment such as percutaneous ablation therapy and/or TACE although this was preliminary result because the number of cases was small (Figure 7).…”

Section: Discussionmentioning

confidence: 75%

Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function

Okajima¹,

Komatsu²,

Ichikawa³

et al. 2016

European Journal of Cancer

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Section: Discussionmentioning

confidence: 75%

Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function

Okajima¹,

Komatsu²,

Ichikawa³

et al. 2016

European Journal of Cancer

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“…Regarding the diagnosis of hypervascular HCC, a study comparing the results of image reconstruction with collimation at 2.5, 5, and 7.5 mm reported no significant difference in the diagnostic accuracy for lesions of ≤5 mm [31]. From the viewpoint of hemodynamics, few HCCs ≤5 mm in diameter exhibit hypervascularity during the course of their growth, except for intrahepatic metastases, and collimation at 5 mm is therefore considered appropriate for screening [32].…”

Section: Improvements On Ctmentioning

confidence: 99%

Diagnostic Imaging of Hepatocellular Carcinoma: Recent Progress

Kudo

2011

Oncology

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The diagnostic imaging of hepatocellular carcinoma (HCC) has recently undergone marked progress. The advent of the ultrasound (US) contrast agent Sonazoid, approved in January 2007, and magnetic resonance imaging (MRI) with the liver-specific MRI contrast agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA-MRI), approved in January 2008, are of particular significance. Sonazoid contrast-enhanced US (Sonazoid-CEUS) is useful not only for the diagnosis of HCC, but also for guiding treatment and assessing treatment response. Sonazoid-CEUS has proven to be particularly effective for screening and staging, which used to be considered impossible with CEUS, through the introduction of the newly developed diagnostic technique of defect reperfusion imaging. It is still not possible if other vascular agents such as SonoVue and Definity are used. In particular, Gd–EOB-DTPA-MRI has been suggested to be much more reliable in the differentiation of early HCC from precancerous dysplastic nodules than any other modalities such as multidetector raw computed tomography, dynamic MRI, and superparamagnetic iron oxide-MRI. A decrease in contrast uptake in the hepatocyte phase observed on EOB-MRI is strongly suggestive of cancer, and the absence of early staining in the arterial phase suggests early HCC. The differential diagnostic capacity of Gd-EOB-DTPA-MRI is considered to far exceed that of what were previously the most useful imaging techniques, computed tomography (CT) during hepatic arteriography or CT during arterial portography, and to be comparable to that of the pathological diagnosis by pathologists specialized in liver.

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“…A pitch of 12 or 6, respectively, with the table speed set at 15 mm/rotation can be employed. One rotation of the X-ray tube lasts 0.5 s. The axial images are reconstructed and displayed as 40 5-mm-thick slices for each phase set because there is no significant difference in detection sensitivity of HCC between 2.5-and 5-mm-thick slices [24]. Helical CT data for each phase are retrospectively reconstructed for multiplanar reconstruction images or CT angiography with a standard soft algorithm (maximum intensity projection or volume rendering) at 0.63-mm increments with a 1.25-mm section thickness or 1.25-mm increments with a 2.5-mm section thickness, respectively, and a 30-cm field of view.…”

Section: Imaging Techniques Of Mdctmentioning

confidence: 99%

Multidetector Row CT and MR Imaging in Diagnosing Hepatocellular Carcinoma

Murakami

Hori²,

Kim³

et al. 2004

Intervirology

Self Cite

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It is important to diagnose hepatocellular carcinoma (HCC) correctly and in early stage, because viral hepatitis and liver cirrhosis are often complicated by HCC. Noncontrast and enhanced CT and MRI are very useful to visualize and diagnose HCC objectively. Especially, CT and MR imaging with dynamic study is essential to diagnose HCC, because it is usually hypervascular. Dynamic CT and MR study also improve differential diagnosis in the characterization of the tumor. However, to perform useful dynamic study, it is necessary to use a CT unit which can make a helical scan, or a MR system with fast imaging technique available that can obtain more than 15 slices within a single breath hold. Tissue specific contrast medium, such as superparamagnetic iron oxide that is available only on MRI, is also useful for diagnosis of HCC.

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Multidetector CT: Diagnostic Impact of Slice Thickness on Detection of Hypervascular Hepatocellular Carcinoma

Cited by 81 publications

References 21 publications

Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function

Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function

Diagnostic Imaging of Hepatocellular Carcinoma: Recent Progress

Multidetector Row CT and MR Imaging in Diagnosing Hepatocellular Carcinoma

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