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                     <i>Severe Anaphylactic Reaction Due to a Chlorhexidine-impregnated Central Venous Catheter</i> </b>

Terazawa, Etsuji; Shimonaka, Hiroyuki; Nagase, Kenji; Masue, Tatsuhiko; Dohi, Shuji

doi:10.1097/00000542-199811000-00060

Cited by 49 publications

(23 citation statements)

References 2 publications

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“…Clinical features of tachycardia, hypotension and erythematous skin were reported in at least three cases in the literature in relation to insertion of chlorhexidine based central line [3,6,7]. Bronchospasm was not a prominent feature in these cases, it is only featured in 43% of patients [6].…”

Section: Discussionmentioning

confidence: 93%

Chlorhexidine Impregnated Central Venous Catheter Inducing an Anaphylatic Shock in the Intensive Care Unit

Khoo

Oziemski

2011

Heart, Lung and Circulation

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Section: Discussionmentioning

confidence: 93%

Chlorhexidine Impregnated Central Venous Catheter Inducing an Anaphylatic Shock in the Intensive Care Unit

Khoo

Oziemski

2011

Heart, Lung and Circulation

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“…But in general, the prophylactic use of antibiotic-coated implants increases the risk of producing resistant strains of bacteria, while the use of other kinds of antibacterial compounds (antiseptics) provides inferior results in comparison to the use of clinical antibiotics. Antiseptic-based coatings have also been associated with reports of anaphylactic shock [2][3][4]. Lantibiotics are antibiotic compounds that include one or more lanthionine rings.…”

Section: Introductionmentioning

confidence: 99%

Nisin adsorption to hydrophobic surfaces coated with the PEO–PPO–PEO triblock surfactant Pluronic® F108

Tai¹,

Joshi²,

McGuire³

et al. 2008

Journal of Colloid and Interface Science

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The adsorption and elution of the antimicrobial peptide nisin at hydrophobic, silanized silica surfaces coated with the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) surfactant Pluronic F108 were measured in situ, with ellipsometry. While such layers are known to inhibit protein adsorption, nisin was observed to adsorb in multilayer quantities, to an extent similar to its adsorption at uncoated, hydrophobic surfaces. The rates of nisin adsorption and elution were generally slower at F108-coated surfaces. And, the sequential adsorption of nisin, including two adsorption-elution cycles at each surface, showed greater differences in adsorption rates between the first and second adsorption cycles, when evaluated at identical mass density, for uncoated relative to F108-coated surfaces. These results indicate that nisin adsorption occurs via "entrapment" within the PEO brush layer at F108-coated surfaces, in this way slowing adsorption and spontaneous elution, and inhibiting post-adsorptive molecular rearrangements by reducing the lateral mobility of nisin. While F108-coated layers rejected adsorption of serum albumin, sequential adsorption experiments carried out with nisin and albumin showed a low level of albumin adsorption when nisin was present at the interface.

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“…One is the possibility of allergic reactions to the antimicrobial agentda potential complication that has been reported in some cases. [18][19][20][21] Another is the potential risk of developing antimicrobial resistance to the agent used in impregnated catheters. 22,23 Although in our study no adverse events were identified, the sample size is likely too small to draw any conclusions about adverse events.…”

Section: Discussionmentioning

confidence: 99%

Cost/benefit analysis of chlorhexidine-silver sulfadiazine-impregnated venous catheters for femoral access

Lorente

Lecuona

Jiménez

et al. 2014

American Journal of Infection Control

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Severe Anaphylactic Reaction Due to a Chlorhexidine-impregnated Central Venous Catheter

Cited by 49 publications

References 2 publications

Chlorhexidine Impregnated Central Venous Catheter Inducing an Anaphylatic Shock in the Intensive Care Unit

Chlorhexidine Impregnated Central Venous Catheter Inducing an Anaphylatic Shock in the Intensive Care Unit

Nisin adsorption to hydrophobic surfaces coated with the PEO–PPO–PEO triblock surfactant Pluronic® F108

Cost/benefit analysis of chlorhexidine-silver sulfadiazine-impregnated venous catheters for femoral access

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