<b>Expression of follicle‐stimulating hormone receptor in human ovary</b>

Minegishi, Takashi; Tano, Mari; Igarashi, Masao; Rokukawa, S.; Abe, Yumiko; Ibuki, Yoshito; Miyamoto, Kaoru

doi:10.1046/j.1365-2362.1997.1350682.x

Cited by 36 publications

(21 citation statements)

References 17 publications

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“…Although it is well established that FSH regulates secretion of both forms of INH, but in this study, exogenous FSH treatment did not result in elevated INH A concentrations. This finding is not surprising, since it is well known that FSH receptor expression becomes down regulated or undergoes extinction after ovulation and luteinization [Minegishi et al, 1997]. We have observed low mRNA expression of FSH receptor in the CL throughout the luteal phase, and this may have contributed to lack of response to exogenous FSH treatment and thus absence of increase in INH A concentration.…”

Section: Discussionsupporting

confidence: 65%

Dynamics of circulating concentrations of gonadotropins and ovarian hormones throughout the menstrual cycle in the bonnet monkey: role of inhibin A in the regulation of follicle‐stimulating hormone secretion

Suresh

Medhamurthy

2009

American J Primatol

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In higher primates, increased circulating follicle-stimulating hormone (FSH) levels seen during late menstrual cycle and during menstruation has been suggested to be necessary for initiation of follicular growth, recruitment of follicles and eventually culminating in ovulation of a single follicle. With a view to establish the dynamics of circulating FSH secretion with that of inhibin A (INH A) and progesterone (P(4)) secretions during the menstrual cycle, blood was collected daily from bonnet monkeys beginning day 1 of the menstrual cycle up to 35 days. Serum INH A levels were low during early follicular phase, increased significantly coinciding with the mid cycle luteinizing hormone (LH) surge to reach maximal levels during the mid luteal phase before declining at the late luteal phase, essentially paralleling the pattern of P(4) secretion seen throughout the luteal phase. Circulating FSH levels were low during early and mid luteal phases, but progressively increased during the late luteal phase and remained high for few days after the onset of menses. In another experiment, lutectomy performed during the mid luteal phase resulted in significant decrease in INH A concentration within 2 hr (58.3+/-2 vs. 27.3+/-3 pg/mL), and a 2- to 3-fold rise in circulating FSH levels by 24 hr (0.20+/-0.02 vs. 0.53+/-0.14 ng/mL) that remained high until 48 hr postlutectomy. Systemic administration of Cetrorelix (150 microg/kg body weight), a gonadotropin releasing hormone receptor antagonist, at mid luteal phase in monkeys led to suppression of serum INH A and P(4) concentrations 24 hr post treatment, but circulating FSH levels did not change. Administration of exogenous LH, but not FSH, significantly increased INH A concentration. The results taken together suggest a tight coupling between LH and INH A secretion and that INH A is largely responsible for maintenance of low FSH concentration seen during the luteal phase.

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Section: Discussionsupporting

confidence: 65%

Dynamics of circulating concentrations of gonadotropins and ovarian hormones throughout the menstrual cycle in the bonnet monkey: role of inhibin A in the regulation of follicle‐stimulating hormone secretion

Suresh

Medhamurthy

2009

American J Primatol

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“…LH receptor expression has been found in the skin, adrenal, vasculature, urinary bladder, duodenum, pancreas (rat), lung, brain (including neurons, astrocytes and microglia) and monocytes [Ascoli et al, 2002;Bukovsky et al, 2003]. To date FSH receptor expression in nonreproductive tissues has not been reported, and has only been documented as being localized to reproductive tissues: ovary, prostate, testis, corpus luteum, and placenta [Heckert and Griswold, 1991;Minegishi et al, 1997;Xing and Sairam, 2001]. If GnRH and/or LH are the mitogenic factors driving growth (cell proliferation), the question becomes what are the differentiating factors that limit growth and allow for cell specific function.…”

Section: Mitogenic Factor(s)mentioning

confidence: 99%

Living and Dying for Sex

2004

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A mechanistic understanding of aging has yet to be described; this paper puts forth a new theory that has the potential to explain aging in all sexually reproductive life forms. The theory also puts forth a new definition of aging – any change in an organism over time. This definition includes not only the changes associated with the loss of function (i.e. senescence, the commonly accepted definition of aging), but also the changes associated with the gain of function (growth and development). Using this definition, the rate of aging would be synonymous with the rate of change. The rate of change/aging is most rapid during the fetal period when organisms develop from a single cell at conception to a multicellular organism at birth. Therefore, ‘fetal aging’ would be determined by factors regulating the rate of mitogenesis, differentiation, and cell death. We suggest that these factors also are responsible for regulating aging throughout life. Thus, whatever controls mitogenesis, differentiation and cell death must also control aging. Since life-extending modalities consistently affect reproduction, and reproductive hormones are known to regulate mitogenesis and differentiation, we propose that aging is primarily regulated by the hormones that control reproduction (hence, the Reproductive-Cell Cycle Theory of Aging). In mammals, reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis hormones. Longevity inducing interventions, including caloric restriction, decrease fertility by suppressing HPG axis hormones and HPG hormones are known to affect signaling through the well-documented longevity regulating GH/IGF-1/PI3K/Akt/Forkhead pathway. This is exemplified by genetic alterations in Caenorhabditis elegans where homologues of the HPG axis pathways, as well as the daf-2 and daf-9 pathways, all converge on daf-16, the homologue of human Forkhead that functions in the regulation of cell cycle events. In summary, we propose that the hormones that regulate reproduction act in an antagonistic pleiotrophic manner to control aging via cell cycle signaling; promoting growth and development early in life in order to achieve reproduction, but later in life, in a futile attempt to maintain reproduction, become dysregulated and drive senescence.

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“…Kumar (2009). This assumption is supported by the detection of the FSH receptor in the human CL (Minegishi et al 1997). Furthermore, bioactive FSH levels were shown to be elevated only in the mid-luteal to late luteal phase of the human menstrual cycle (Christin-Maitre et al 1996).…”

Section: Discussionmentioning

confidence: 95%

Luteotrophic effects of relaxin, chorionic gonadotrophin and FSH in common marmoset monkeys (Callithrix jacchus)

Beindorff¹,

Einspanier²

2010

Reproduction

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In early pregnant primates, relaxin (RLX) is highly upregulated within the corpus luteum (CL), suggesting that RLX may have an important role in the implantation of the blastocyst. Therefore, the aim of the present study was to investigate the local effects of RLX and gonadotrophins on the maintenance of the CL using an in vitro microdialysis system. CLs of common marmoset monkeys were collected by luteectomy during different stages of the luteal phase and early pregnancy. Each CL was perfused with either Ringer's solution alone or Ringer's solution supplemented with either porcine RLX (250, 500 and 1000 ng/ml) or gonadotrophins (50 IU/ml). Application of RLX provoked a significant luteal response of progesterone (P 4 ) and oestradiol (E 2 ) secretions during the mid-luteal phase (500 ng/ml: P 4 54G42%, E 2 24G11%; 1000 ng/ml: E 2 16G13%), and especially during the late luteal phase (250 ng/ml: P 4 53G10%; 500 ng/ml: P 4 44G15%; 1000 ng/ml: P 4 62G15%, E 2 18G7%). The effects of RLX on steroid secretion were irrespective of the RLX dosages. While treatment with human chorionic gonadotrophin did not affect luteal steroid or RLX secretion, the application of FSH resulted in a significant increase in the secretion of both P 4 (20G8%) and E 2 (37G28%), and a prominent rise in RLX during early pregnancy. In conclusion, our results demonstrate that RLX and FSH have a luteotrophic function in the marmoset monkeys; moreover, FSH has a function beyond its traditional role just as a follicle-stimulating hormone.Reproduction (2010) 139 923-930

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Expression of follicle‐stimulating hormone receptor in human ovary

Cited by 36 publications

References 17 publications

Dynamics of circulating concentrations of gonadotropins and ovarian hormones throughout the menstrual cycle in the bonnet monkey: role of inhibin A in the regulation of follicle‐stimulating hormone secretion

Dynamics of circulating concentrations of gonadotropins and ovarian hormones throughout the menstrual cycle in the bonnet monkey: role of inhibin A in the regulation of follicle‐stimulating hormone secretion

Living and Dying for Sex

Luteotrophic effects of relaxin, chorionic gonadotrophin and FSH in common marmoset monkeys (Callithrix jacchus)

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