B cells develop in the zebrafish pancreas

Danilova, Nadia; Steiner, Lisa A.

doi:10.1073/pnas.212515999

Cited by 129 publications

(87 citation statements)

References 36 publications

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“…The first location is consistent with data in mammals where cryptopatches in the lamina propria are associated with the generation of IEL (Matsunaga 1998;Cheroutre 2004). In contrast to our data, rag-1 was abundantly expressed in both intestinal epithelium and lamina propria in zebrafish (cyprinidae) (Danilova and Steiner 2002), suggesting that the extent of extrathymic T cell production might differ among fish species.…”

Section: Discussionsupporting

confidence: 92%

The ontogeny of mucosal immune cells in common carp (Cyprinus carpio L.)

et al. 2005

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The ontogeny of carp (Cyprinus carpio L.) immune cells was studied in mucosal organs (intestine, gills and skin) using the monoclonal antibodies WCL38 (intraepithelial lymphocytes), WCL15 (monocytes/macrophages) and WCI12 (B cells). In addition, recombination activating gene 1 expression was examined in the intestine with real time quantitative PCR and in situ hybridization to investigate extrathymic generation of lymphocytes. WCL38 + intraepithelial lymphocytes (putative T cells) appeared in the intestine at 3 days postfertilization (dpf), which is shortly after hatching but before feeding, implying an important function at early age. These lymphoid cells appear in the intestine before the observation of the first thymocytes at 3-4 dpf, and together with the expression of recombination activating gene 1 in the intestine, suggests that similar to mammals at least part of these cells are generated in the intestine. WCL15 + monocytes/macrophages appeared in the lamina propria of the intestine at 7 dpf, but considerably later in the epithelium, while WCI12 + (B) cells appeared in intestine and gills at 6-7 weeks. From these results it can be concluded that putative T cells occur much earlier than B cells, and that B cells appear much later in the mucosae than in other internal lymphoid organs (2 wpf).

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Section: Discussionsupporting

confidence: 92%

The ontogeny of mucosal immune cells in common carp (Cyprinus carpio L.)

et al. 2005

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“…TCRα chain expression begins in the zebrafish thymus at 4 dpf (Danilova et al, 2004) two days after the appearance of the first lymphoid cells in the organ (Willett et al, 1999). Studies also demonstrated the pronephros as the first extrathymic site of Rag-2 expression at 8 dpf (Trede et al, 2004), and Rag1 was observed expression in the zebrafish pancreas by day 4 (Danilova and Steiner, 2002). These genes could be instrumental for studying the development and function of thymus in fish larval stages.…”

Section: Introductionmentioning

confidence: 94%

Effects of pure microcystin-LR on the transcription of immune related genes and heat shock proteins in larval stage of zebrafish (Danio rerio)

Sun

et al. 2009

Aquaculture

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“…These secretory cells are analogues of the mammalian plasma cells and are known as antibody secreting cells (ASCs) or plasmablasts [31]. The largest concentration of B-lymphocytes exists in the pronephros and, accordingly, this region is also rich in immunoglobulins [32]. The incorporation of surface-bound immunoglobulins on the membrane of the B-cell is also naturally occurring and allows for further antigen interactions and subsequent pathogen removal or control.…”

Section: Teleost Adaptive Immunitymentioning

confidence: 99%

A Review of Immune System Components, Cytokines, and Immunostimulants in Cultured Finfish Species

Bruce¹,

Brown²

2017

OJAS

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Aquaculture is a rapidly growing global agriculture sector and the importance of fish health has become of upmost importance as production levels and stocking densities increase. Over the past few decades, there have been a large number of immunological investigations on commonly cultured finfish species. Further, new technologies and strategies that embody use of fish immunostimulants, probiotics, and vaccinology rely heavily upon a comprehensive understanding of teleost immune system mechanics. The teleost immune system works in concert to properly recognize, control, and clear aquatic pathogens. Recent findings have exemplified the cooperative efforts of the nonspecific and adaptive branches, and have put forth an emphasis on the importance of the mucosal immune response in all aspects of a mounted immune response. This review provides a generalized overview of the innate and adaptive arms of the fish immune system, and provides highlights of recently published work in the areas of signaling networks and mucosal immune interactions.

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B cells develop in the zebrafish pancreas

Cited by 129 publications

References 36 publications

The ontogeny of mucosal immune cells in common carp (Cyprinus carpio L.)

The ontogeny of mucosal immune cells in common carp (Cyprinus carpio L.)

Effects of pure microcystin-LR on the transcription of immune related genes and heat shock proteins in larval stage of zebrafish (Danio rerio)

A Review of Immune System Components, Cytokines, and Immunostimulants in Cultured Finfish Species

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