“B-cell” mitogenicity of carragheenan in mouse

Quan, Phuc Canh; Kolb, Jean-Pierre; Lespinats, G

doi:10.1016/0008-8749(78)90168-5

Cited by 24 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The origin, maintenance, and handling of T. musculi in our laboratory have been thoroughly described (22,23 vestigation (12), from which it was learned that a parasite infection provides a powerful stimulus, at least as effective as injection of poly(IC) or, in comparison to other reports, as effective as bacterial endotoxin, Newcastle disease virus (24), or carrageenan (25) vis-a-vis NK stimulation.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Age-associated impairment of murine natural killer activity.

Albright¹,

Albright²

1983

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Natural cell-mediated cytotoxicity may be critical in. the resistance displayed by animals.and humans to tumors and various pathogenic microorganisms. Because the frequency of tumors and infections increases markedly in aging populations, we have compared the natural killer (NK) competence of lymphid tissues (spleen, bone marrow) and of peritoneal cells of young adult and aged mice. Spontaneous NK activity was much lower, and the rate of. target cell lysis was much less, in aged mice. The level of NK activitywas only modestly increased in old, compared to young, mice when they were exposed to Trypanosoma. muscwli, an organism that provides strong stimulation of NK activity. Restricted NK activity of aged mice was not attributable to suppressor cells. The NK effector cells in old mice were characterized as being nonadherent to plastic, completely susceptible to lysis by complement plus an antiserum against specificity NK 1.2, and only slightly affected by treatment with antiserum against specificity Thy-1.2. Two indirect methods were employed to assess the-relative frequency of splenic NK cells at the time of-maximal stimulation by T. musculi: a cytotoxicity assay-with antiserum against NK 1.2 and a binding assay involving monolayers of YAC-1 tumor target cells. Similar results were obtained in both assays, indicating that at maximal stimulation about 10% of the total spleen cells of both young and old mice were NK cells. We conclude (cautiously) that the functional efficiency of aged NK cells is impaired and that this -defect may account, in part, for reduced ability of aged individuals to resist certain types of cancer and certain pathogenic microorganisms.Many biological and medical scientists believe that the declining competence of the immune system is responsible, in part, for the progressive rise in the frequency of. neoplastic and infectious. diseases associated with biological aging. The veracity of this postulate could be better judged if more were known about the immunological processes involved in responses to, and reactions with, tumor cells and pathogenic organisms. One feature of the immune system that has received considerable -attention in recent years is that of spontaneous, or natural, cellmediated cytotoxicity, associated especially with the subset of lymphocytes termed "natural killer" (NK) (1, 2). A variety of tumors (3, 4) and several pathogens (5-7) have been found to be susceptible to NK cells. The most clear-cut example of the susceptibility of a pathogen to NK cells is that of the human pathogen Trypanosoma cruzi (7). In addition, a number of other protozoan parasites have been found to alter markedly the NK activity of lymphoid tissues of their hosts (8-12).At present, information about the status of NK cells and their functional capabilities in aging animals and humans is meager. In most strains of mice,-NK activity in lymphoid tissues is high-.est in mice that are 1-3 months of age and declines considerably thereafter (13)(14)(15). Little is known about-NK cells and activity...

show abstract

Section: Methodsmentioning

confidence: 99%

“…and pans were replaced twice per week. The ages of the mice employed in the experiments were young, 3-5 months; old, [24][25][26][27][28][29][30] months.…”

Section: Methodsmentioning

confidence: 99%

Age-associated impairment of murine natural killer activity.

Albright¹,

Albright²

1983

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Following the secondary Salmonella injection, the bursal follicles showed a moderate increase in the lymphoid cellularity of the medulla area. This increased cellularity may have resulted from the carrageenan and/or the LPS-lipopolysaccharide from the Salmonella It has been reported that the carrageenan-stimulated B-cell subpopulation is different from that which is sensitive to dextran sulfate and LPS (Quan et al, 1978: Kolb et al, 1981. Since there was no increase in the cellularity of the medulla in the control Salmonella-injected chicks, the high cellularity in the carrageenan-treated birds may be due to the carrageenan.…”

Section: Discussionmentioning

confidence: 94%

“…Carrageenan is an immunosuppressive agent which is toxic for macrophages but not for lymphocytes (Schwartz and Leskowitz, 1969;Lake et al, 1971;Catanzaro et al, 1971;Thomson and Horne, 1975;Lee and A1-Izzi, 1981;Hurtrel and Lagrange, 1981). While there is evidence that this sulfated polysaccharide could be mitogenic for both B (Quan et al, 1978;Kolb et al, 1981) and T cells (Sugawara and Ishizaka, 1982), there are reports that carrageenan inhibited T-cell proliferation (Bash and Vago, 1980;Bash and Cochran, 1980). Carrageenan is also a potent adjuvant (Mizushima et al, 1974;Quan et al, 1978;Kearney et al, 1979).…”

mentioning

confidence: 99%

Effect of carrageenan on the histology of the bursa of fabricius and the humoral immune response to SalmonellaO antigen

Oláh

Glick

1986

Anat. Rec.

View full text Add to dashboard Cite

Bursal secretory cells have been studied with light and electron microscope after prolonged carrageenan treatment. Intravenous injected carrageenan decreased the number of secretory cells as early as 4 days after the first carrageenan administration. Degranulation of the secretory cells may have made it difficult to identify these cells. The discharge of granules from the secretory cells was indicated by the appearance of a large amount of extracellular substance on the cell surface. The carrageenan may have accelerated the IgM-IgG switch after immunization with Salmonella O antigen. The rapid IgM-IgG switch was preceded by degranulations of the secretory cells. Therefore, the secretory products of the cells might have contributed to the switch. The number of secretory cells in the carrageenan-treated birds increased by the secondary immunization. Many of these secretory cells were immature and located close to the corticomedullary border. The young cells revealed a large blastlike nucleus and bulky cytoplasm with granules surrounding the cytocentrum and Golgi zone.

show abstract

“…The optimization results of MOEAs are a group of optimal solutions that approximate to the PF, but it is difficult to measure the quality of the nondominated solutions. Therefore, this paper uses the GD [40], SP [41] and IGD [42] as the performance measuring methods to evaluate the convergence, distribution and comprehensive performance of the obtained solutions.…”

Section: B Performance Indicatorsmentioning

confidence: 99%

Preference-Inspired Coevolutionary Algorithm Based on Differentiated Resource Allocation Strategy

Qiu

Wang

et al. 2020

IEEE Access

View full text Add to dashboard Cite

Preference-inspired co-evolutionary algorithms (PICEAs) consider the target vectors as the preferences, and then use the domination relationship between the candidate solutions and target vectors to increase their selection pressure. However, the size of dominating objective space varies with the different positions of candidate solutions and it leads to the imbalance of the evolutionary ability of whole population. To solve this problem, this paper proposes a preference-inspired coevolutionary algorithm based on a differentiated allocation strategy (PICEAg-DS). First, it sets up an external archive to save the nondominated solutions and then extracts the convergence and diversity information from it. Second, it divides the objective space into several subspaces and designs a space distance operator to evaluate their optimization difficulty. Finally, it dynamically assigns the target vectors and guides more computational resource to the difficult to optimize subspaces, and thus drives the whole population evolution. To prove the advantages of differentiated resource allocation strategy, the PICEAg-DS is compared with two classic coevolutionary algorithms (PICEAg, CMOPSO) and two classic MOEAs based on resource allocation strategy (EAG-MOEAD, MOEAD-DRA). The experimental results show that PICEAg-DS performs better than the other algorithms on many WFG test problems. To further analysis the effectiveness of PICEAg-DS, compare it with two MOEAs based on domination relationship (NSGAII, SPEA2) and two MOEAs based on decomposition (RVEA, MOEA/D-M2M) on MOP and UF test suite. The experimental results show the PICEAg-DS has a better convergence than the other comparison algorithms, especially on 3-objective MOP6-7 and UF8-9.

show abstract

“B-cell” mitogenicity of carragheenan in mouse

Cited by 24 publications

References 13 publications

Age-associated impairment of murine natural killer activity.

Age-associated impairment of murine natural killer activity.

Effect of carrageenan on the histology of the bursa of fabricius and the humoral immune response to SalmonellaO antigen

Preference-Inspired Coevolutionary Algorithm Based on Differentiated Resource Allocation Strategy

Contact Info

Product

Resources

About