Effect of carrageenan on the histology of the bursa of fabricius and the humoral immune response to SalmonellaO antigen

Abstract

Bursal secretory cells have been studied with light and electron microscope after prolonged carrageenan treatment. Intravenous injected carrageenan decreased the number of secretory cells as early as 4 days after the first carrageenan administration. Degranulation of the secretory cells may have made it difficult to identify these cells. The discharge of granules from the secretory cells was indicated by the appearance of a large amount of extracellular substance on the cell surface. The carrageenan may have accelerated the IgM-IgG switch after immunization with Salmonella O antigen. The rapid IgM-IgG switch was preceded by degranulations of the secretory cells. Therefore, the secretory products of the cells might have contributed to the switch. The number of secretory cells in the carrageenan-treated birds increased by the secondary immunization. Many of these secretory cells were immature and located close to the corticomedullary border. The young cells revealed a large blastlike nucleus and bulky cytoplasm with granules surrounding the cytocentrum and Golgi zone.

Bacteroides vulgatus outer membrane antigens associated with carrageenan-induced colitis in guinea pigs

“…The adjuvant role of carrageenan challenge is also unclear; carrageenan has been found to inhibit macrophage-lymphocyte interactions (2), induce changes in gut epithelial glycoproteins (1), and accelerate the immunoglobulin M-immunoglobulin G switch after immunization with Salmonella sp. 0 antigen (16).…”

Life cycle of chicken bursal secretory dendritic cell (BSDC)

“…This novel cell shows a well-developed Golgi complex with secretory granules in control birds. Around the cell, there is a fine-flocculated substance ( Olah and Glick, 1986 , 1987 ). Based on these findings, we named this cell secretory cell.…”

“…During the last 45 yr, we have published numerous papers about the structure ( Olah and Glick, 1987 ), characterization ( Olah et al, 1992 ; Olah and Glick, 1992 ; Pharr et al, 1995 ; Oláh and Nagy, 2013 ; Nagy et al, 2016 ), changes in the experimental condition ( Olah and Glick, 1978b , 1986 ; Olah et al, 1979 ), glycoprotein production ( Felföldi et al, 2021 ; Oláh et al, 2022 ) and effect of IBDV infection ( Felföldi et al, 2022 ; Oláh et al, 2023 ) of the BSDC.…”