B Cell Lymphoma Showing Clinicopathological Features of Malignant Histiocytosis

Kuratsune, Hirohiko; Machii, Takashi; Aozasa, Katsuyuki; Ueda, Etsuko; Tokumine, Yukihiro; Morita, Takako; Tagawa, Shinichi; Taniguchi, N; Inoue, Ryosai; Kitani, Teruo

doi:10.1159/000205729

Cited by 26 publications

(16 citation statements)

References 5 publications

(6 reference statements)

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“…However, autopsies of two cases revealed histopathologic findings which were characteristic of IVL. Based on these observations, careful investigation of the other three cases of the present series and the nine cases previously described as MH-like BCL in the Japanese literature (Kuratsune et al, 1988;Sakai et al, 1991;Imai et al, 1992;Iwahashi et al, 1992;Takeshita et al, 1993;Yamada et al, 1996) suggests that most of them might fall within the framework of IVL and form a distinct variant.…”

supporting

confidence: 52%

Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

Murase¹,

Nakamura

Tashiro³

et al. 1997

Br J Haematol

102

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Summary. Malignant histiocytosis (MH)-like B-cell lymphoma (BCL) is a neoplastic proliferation of large B cellsclinically characterized by fever, hepatosplenomegaly, haemophagocytosis and abnormal laboratory data, without lymphadenopathy or skin lesions. Interestingly, most cases have been reported in Asian patients, and it is unclear whether MH-like BCL is biologically distinct from conventional large B-cell lymphomas. We report five Japanese patients with MH-like BCL. Biopsied specimens of bone marrow, liver and/or spleen showed infiltration of neoplastic B cells accompanied by haemophagocytosing histiocytes. Lymphoma cells were positive for CD19, CD20 and HLA-DR surface antigens, and negative for CD5 and CD10. In four cases elevated serum levels of interleukin (IL)-6 and the soluble IL-2 receptor isoform were noted, but not IL-1b, IL-2 or tumour necrosis factor-a. Autopsies of two cases were pathologically diagnosed as intravascular lymphomatosis (IVL). Based on these observations, the current and nine previous cases reported as MH-like BCL in Japan were reevaluated. They appear to form a peculiar variant of IVL, characterized by bone marrow involvement at presentation, haemophagocytic syndrome, and a rapidly aggressive clinical course, but rarely neurological complications or skin lesions. This variant may merit separate consideration because of the problems posed in the initial diagnosis and therapeutic approaches.

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supporting

confidence: 52%

Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

Murase¹,

Nakamura

Tashiro³

et al. 1997

Br J Haematol

102

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“…2 In many lymphomas associated with HPS, tumor cells were of T cell origin; 3-5 but some cases of B cell lymphoma-associated HPS have also been reported. [6][7][8][9] Wong and Chan 10 retrospectively analyzed 40 HPS cases and found 16 lymphoma cases (T lineage, six; B lineage, three; lineage not determined, seven). Similar to the present case, HPS was the initial presentation of the lymphoma in 10 of these cases.…”

Section: Discussionmentioning

confidence: 99%

B cell lymphoma-associated hemophagocytic syndrome after PBSCT

Takahashi

Kanda

Mori

et al. 1998

Bone Marrow Transplant

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Summary:Hemophagocytic syndrome (HPS) associated with T cell lymphoma is well known, but an association with B cell lymphoma is rare. We report a patient who developed subcutaneous non-Hodgkin's lymphoma (NHL) of B cell origin. Autologous peripheral blood stem cell transplantation (PBSCT) was undertaken in her second complete remission (CR), but HPS appeared 5 months after transplantation. The patient deteriorated rapidly and died of metabolic acidosis. Necropsy revealed that she had relapsed B cell NHL involving liver, spleen and bone marrow. B cell NHL after PBSCT, associated with HPS as an initial sign, is rare. We report this case and review the literature. Keywords: subcutaneous B cell lymphoma; PBSCT; hemophagocytic syndrome Although T cell lymphoma-associated hemophagocytic syndrome (HPS) is frequently observed, B cell lymphomaassociated HPS is rare. We report a case of B cell nonHodgkin's lymphoma (NHL) with HPS after peripheral blood stem cell transplantation (PBSCT). Case reportA 43-year-old previously healthy female noticed two skin tumors (1 cm and 1.5 cm in diameter) underneath the right breast in January 1994. Histological diagnosis of the resected tumors was diffuse large cell NHL, according to the Working Formulation classification, which appeared to grow from the subcutaneous tissue (Figure 1a). Immunohistochemical study revealed that the tumor cells were derived from B cells. She was then referred to our hospital for further examination and treatment. No nodal or extranodal involvement was found apart from the original subcutaneous tumors, and clinical stage of I EA was defined. She achieved complete remission (CR) after six cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy. Two months later, subcutane- ous tumors developed on her face, breast and thighs. Recurrent NHL was diagnosed, based on histological study of the tumors. On surface marker analysis, the lymphoma cells were positive for CD10, CD19, CD20 and HLA-DR. Southern blot analysis showed rearrangement of the immunoglobulin heavy chain gene (IgH) but not the TCR␤ gene. A second CR was achieved with one course of salvage chemotherapy comprising carboplatin, cytosine arabinoside, etoposide, mitoxantrone, and prednisolone. In July 1995, autologous PBSCT was carried out with 2.2 × 10 6 /kg of CD34-positive cells, following a preparatory regimen

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“…Before the advent of immunohistological examination, the absence of mass formation and the diffuse infiltration of large neoplastic cells into the red pulp might have been diagnosed as malignant histiocytosis [3]. Kuratsune et al [4] reported the first case of DLBCL that non-cohesively proliferated into the splenic red pulp and demonstrated clinicopathological features of malignant histiocytosis. Since their initial report, only 18 cases of DLBCLs non-cohesively infiltrating the splenic red pulp have been reported [4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…To clarify the features of this rare lymphoma, we describe six new cases of DLBCLRP and present an analysis of the clinicopathological features of an additional 18 previously reported cases [4][5][6][7][8][9][10][11][12][13]. After reviewing the data, we developed seven characteristic features of DLBCLRP.…”

Section: Introductionmentioning

confidence: 99%

Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

et al. 2008

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We evaluated six cases of diffuse large B-cell lymphoma (DLBCL) involving the red pulp of the spleen. All had B symptoms and an aggressive clinical course. The lymphoma cells proliferated diffusely and non-cohesively in the cords of the red pulp. The lymphoma involved the bone marrow in four of the five patients and the liver in all four of the patients examined. However, lymph node (LN) involvement was rare at presentation, and systemic LN involvement was not observed even in the terminal phase. The lymphoma cells infiltrated the intrasinusoidal/intravascular and interstitial spaces of the involved tissues and were detected in the peripheral blood in two of the six patients. CD5-expressing lymphoma cells were detected in four of the five patients examined. Because these cases had some unique clinical features and occurred in distinct splenic sites, we proposed that primary splenic DLBCL manifesting in red pulp is a distinct clinicopathological entity.

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B Cell Lymphoma Showing Clinicopathological Features of Malignant Histiocytosis

Cited by 26 publications

References 5 publications

Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

B cell lymphoma-associated hemophagocytic syndrome after PBSCT

Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

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